MK4MDD

Genetic/Epigenetic Locus Search Cross Data Search

Study Report

Reference

Citation	Yoshimura, 2010 PubMed
Full Info	Yoshimura, S., Okamoto, Y., Onoda, K., Matsunaga, M., Ueda, K., Suzuki, S. and Shigetoyamawaki. (2010) Rostral anterior cingulate cortex activity mediates the relationship between the depressive symptoms and the medial prefrontal cortex activity. J Affect Disord, 122, 76-85.

Study

Hypothesis or Background	Depression is characterized by enhanced self-referential processing of negative emotional stimuli. Imaging studies have suggested that activation of both the medial prefrontal (MPFC) and anterior cingulate cortices (ACC) is associated with self-referential processing. However, whether this pattern of activation occurs in depressed individuals during the self-referential processing of the emotional stimuli had not been investigated to date.
Sample Information	Participants were 13 patients with major depressive disorder and 13 normal controls.
Method Detail	We used block-designed functional magnetic resonance imaging (fMRI) to investigate neural activity during the self-referential judgments of positive and negative valenced personality trait words.
Method Keywords	functional magnetic resonance imaging (fMRI)
Result	Compared with the normal controls, the depressed patients showed hyperactivity in the MPFC and the rostral ACC during the self-referential processing of negative words. In addition, the activity of these regions during self-referential processing of the negative stimuli was correlated with the depressive symptom severity. The rostral ACC activity mediated the correlation between the MPFC activity and the depressive symptoms. Functional connectivity analysis revealed positive connectivities between the MPFC, the rostral ACC, and the amygdala.
Conclusions	The relationships between the MPFC, the rostral ACC, and the amygdala appear to reflect an interaction between the self-referential processing and the negative emotional information processing, and we propose that the strong connection between the MPFC and the rostral ACC is associated with depressive symptoms.
Remark	LIMITATION: Small N and antidepressant effect on imaging data limit the stability of reported findings.

Relationships reported by Yoshimura, 2010

Component A Approved Name (Name in Paper)	Component A Type	Component B Approved Name (Name in Paper)	Component B Type	Statistical Result	Relationship Description	Result Category (Positive/Negative))
medial prefrontal cortex (MPFC) (medial prefrontal cortex (MPFC))	brain morphology and function	Amygdala (amygdala)	brain morphology and function		Functional connectivity analysis revealed positive connectivities between the MPFC, the rostral ACC, and the amygdala.	Positive
Anterior cingulate cortex (anterior cingulate cortices (ACC))	brain morphology and function	Amygdala (amygdala)	brain morphology and function		Functional connectivity analysis revealed positive connectivities between the MPFC, the rostral ACC, and the amygdala.	Positive
MDD	syndrome	medial prefrontal cortex (MPFC) (medial prefrontal cortex (MPFC))	brain morphology and function		Compared with the normal controls, the depressed patients showed hyperactivity in the MPFC and the rostral ACC during the self-referential processing of negative words.	Positive
Depressed mood (depressive symptom)	symptoms	Anterior cingulate cortex (anterior cingulate cortices (ACC))	brain morphology and function		Compared with the normal controls, the depressed patients showed hyperactivity in the MPFC and the rostral ACC during the self-referential processing of negative words. In addition, the activity of these regions during self-referential processing of the negative stimuli was correlated with the depressive symptom severity.	Positive
Anterior cingulate cortex (anterior cingulate cortices (ACC))	brain morphology and function	medial prefrontal cortex (MPFC) (medial prefrontal cortex (MPFC))	brain morphology and function		Functional connectivity analysis revealed positive connectivities between the MPFC, the rostral ACC, and the amygdala.	Positive
MDD	syndrome	Anterior cingulate cortex (anterior cingulate cortices (ACC))	brain morphology and function		Compared with the normal controls, the depressed patients showed hyperactivity in the MPFC and the rostral ACC during the self-referential processing of negative words.	Positive
Depressed mood (depressive symptom)	symptoms	medial prefrontal cortex (MPFC) (medial prefrontal cortex (MPFC))	brain morphology and function		Compared with the normal controls, the depressed patients showed hyperactivity in the MPFC and the rostral ACC during the self-referential processing of negative words. In addition, the activity of these regions during self-referential processing of the negative stimuli was correlated with the depressive symptom severity.	Positive