MK4MDD

Genetic/Epigenetic Locus Search Cross Data Search

Study Report

Reference

Citation	Surguladze, 2010 PubMed
Full Info	Surguladze, S.A., El-Hage, W., Dalgleish, T., Radua, J., Gohier, B. and Phillips, M.L. (2010) Depression is associated with increased sensitivity to signals of disgust: a functional magnetic resonance imaging study. J Psychiatr Res, 44, 894-902.

Study

Hypothesis or Background	Emotions of fear and disgust are related to core symptoms of depression. The neurobiological mechanisms of these associations are poorly understood. This functional magnetic resonance imaging study aimed at examining the Blood oxygenation level dependent (BOLD) response to facial expressions of fear and disgust in patients with major depressive disorder.
Sample Information	Nine patients in an episode of major depression and nine healthy controls.
Method Detail	Nine patients in an episode of major depression and nine healthy controls underwent two functional magnetic resonance imaging experiments where they judged the gender of facial identities displaying different degrees (mild, strong) of fear or disgust, intermixed with non-emotional faces.
Method Keywords	functional magnetic resonance imaging (fMRI)
Result	Compared with healthy controls, patients with depression demonstrated greater activation in left insula, left orbito-frontal gyrus, left middle/inferior temporal gyrus, and right middle/inferior temporal gyrus to expressions of strong disgust. Depressed patients also demonstrated reduced activation in left inferior parietal lobe to mildly fearful faces.
Conclusions	Enhanced activation to facial expressions of disgust may reflect an emotion processing bias that suggests high relevance of emotion of disgust to depression.

Relationships reported by Surguladze, 2010

Component A Approved Name (Name in Paper)	Component A Type	Component B Approved Name (Name in Paper)	Component B Type	Statistical Result	Relationship Description	Result Category (Positive/Negative))
MDD	syndrome	left inferior temporal gyrus (left inferior temporal gyrus)	brain morphology and function		Compared with healthy controls, patients with depression demonstrated greater activation in left middle/inferior temporal gyrus to expressions of strong disgust.	Positive
MDD	syndrome	left insula (left insula)	brain morphology and function		Compared with healthy controls, patients with depression demonstrated greater activation in left insula to expressions of strong disgust.	Positive
MDD	syndrome	left middle temporal gyrus (left middle temporal gyrus)	brain morphology and function		Compared with healthy controls, patients with depression demonstrated greater activation in left middle/inferior temporal gyrus to expressions of strong disgust.	Positive
MDD	syndrome	left orbito-frontal gyrus (left orbito-frontal gyrus)	brain morphology and function		Compared with healthy controls, patients with depression demonstrated greater activation left orbito-frontal gyrus to expressions of strong disgust.	Positive
MDD	syndrome	right inferior temporal gyrus (right inferior temporal gyrus)	brain morphology and function		Compared with healthy controls, patients with depression demonstrated greater activation in right middle/inferior temporal gyrus to expressions of strong disgust.	Positive
MDD	syndrome	right middle temporal gyrus (right middle temporal gyrus)	brain morphology and function		Compared with healthy controls, patients with depression demonstrated greater activation in right middle/inferior temporal gyrus to expressions of strong disgust.	Positive
MDD	syndrome	Cognitive processing bias (emotion processing bias)	cognition and behavior		Enhanced activation to facial expressions of disgust may reflect an emotion processing bias that suggests high relevance of emotion of disgust to depression.	Positive
MDD	syndrome	left inferior parietal cortex (left inferior parietal lobe)	brain morphology and function		Depressed patients also demonstrated reduced activation in left inferior parietal lobe to mildly fearful faces.	Positive