MK4MDD

Genetic/Epigenetic Locus Search Cross Data Search

Study Report

Reference

Citation	Brunswick, 2003 PubMed
Full Info	Brunswick, D.J., Amsterdam, J.D., Mozley, P.D. and Newberg, A. (2003) Greater availability of brain dopamine transporters in major depression shown by [99m Tc]TRODAT-1 SPECT imaging. Am J Psychiatry, 160, 1836-1841.

Study

Hypothesis or Background	Studies of laboratory animals have shown that administration of antidepressants of all pharmacological classes produces changes in dopamine transporter binding affinity. These observations suggest that dopamine transporter function may play a critical role in the pathophysiology of depression. The present study was an examination of the availability of brain dopamine transporter sites in patients with major depression and in healthy comparison subjects.
Sample Information	15 drug-free depressed patients and 46 age- and gender-matched healthy comparison subjects. Patients were required to have taken no antidepressants for at least 7 days, no MAOIs for at least 2 weeks, and no fluoxetine for at least 3 weeks
Method Detail	Single photon emission computed tomographic (SPECT) brain scans were acquired for 15 drug-free depressed patients and 46 age- and gender-matched healthy comparison subjects by using [(99m)Tc]TRODAT-1, a selective dopamine transporter imaging agent. Specific regions of interest in the basal ganglia and supratentorial areas of the brain were examined. Specific uptake values of dopamine transporter [(99m)Tc]TRODAT-1 binding affinity were calculated from the SPECT scan data, and the values for the patients and healthy subjects were compared.
Method Keywords	single photon emission computed tomography (SPECT)
Result	The specific uptake values of [(99m)Tc]TRODAT-1 binding were significantly higher in the right anterior putamen (23%), right posterior putamen (36%), left posterior putamen (18%), and left caudate nucleus (12%) of the patients than in the comparison subjects. These differences persisted when the data were further analyzed according to gender and age.
Conclusions	Dopamine transporter affinity may be higher than normal in the basal ganglia of depressed patients. These findings suggest that dopamine function may be altered in depression and may also be a mechanism of antidepressant activity.

Relationships reported by Brunswick, 2003

Component A Approved Name (Name in Paper)	Component A Type	Component B Approved Name (Name in Paper)	Component B Type	Statistical Result	Relationship Description	Result Category (Positive/Negative))
MDD	syndrome	left putamen (left posterior putamen)	brain morphology and function	higher in the left posterior putamen (18%)	The specific uptake values of [(99m)Tc]TRODAT-1 (a selective dopamine transporter imaging agent) binding were significantly higher in the right anterior putamen (23%), right posterior putamen (36%), left posterior putamen (18%), and left caudate nucleus (12%) of the patients than in the comparison subjects.	Positive
MDD	syndrome	right putamen (right anterior putamen)	brain morphology and function	higher in the right anterior putamen (23%)	The specific uptake values of [(99m)Tc]TRODAT-1 (a selective dopamine transporter imaging agent) binding were significantly higher in the right anterior putamen (23%), right posterior putamen (36%), left posterior putamen (18%), and left caudate nucleus (12%) of the patients than in the comparison subjects.	Positive
MDD	syndrome	right putamen (right posterior putamen)	brain morphology and function	higher in the right posterior putamen (36%)	The specific uptake values of [(99m)Tc]TRODAT-1 (a selective dopamine transporter imaging agent) binding were significantly higher in the right anterior putamen (23%), right posterior putamen (36%), left posterior putamen (18%), and left caudate nucleus (12%) of the patients than in the comparison subjects.	Positive
MDD	syndrome	left caudate (left caudate nucleus)	brain morphology and function	higher in the left caudate nucleus (12%)	The specific uptake values of [(99m)Tc]TRODAT-1 (a selective dopamine transporter imaging agent) binding were significantly higher in the right anterior putamen (23%), right posterior putamen (36%), left posterior putamen (18%), and left caudate nucleus (12%) of the patients than in the comparison subjects.	Positive
left putamen (left posterior putamen)	brain morphology and function	Sodium-dependent dopamine transporter (dopamine transporter)	protein		The specific uptake values of [(99m)Tc]TRODAT-1 (a selective dopamine transporter imaging agent) binding were significantly higher in the right anterior putamen (23%), right posterior putamen (36%), left posterior putamen (18%), and left caudate nucleus (12%) of the patients than in the comparison subjects.	Positive
right putamen (right anterior putamen)	brain morphology and function	Sodium-dependent dopamine transporter (dopamine transporter)	protein		The specific uptake values of [(99m)Tc]TRODAT-1 (a selective dopamine transporter imaging agent) binding were significantly higher in the right anterior putamen (23%), right posterior putamen (36%), left posterior putamen (18%), and left caudate nucleus (12%) of the patients than in the comparison subjects.	Positive
right putamen (right posterior putamen)	brain morphology and function	Sodium-dependent dopamine transporter (dopamine transporter)	protein		The specific uptake values of [(99m)Tc]TRODAT-1 (a selective dopamine transporter imaging agent) binding were significantly higher in the right anterior putamen (23%), right posterior putamen (36%), left posterior putamen (18%), and left caudate nucleus (12%) of the patients than in the comparison subjects.	Positive
MDD	syndrome	Sodium-dependent dopamine transporter (dopamine transporter)	protein		The specific uptake values of [(99m)Tc]TRODAT-1 (a selective dopamine transporter imaging agent) binding were significantly higher in the right anterior putamen (23%), right posterior putamen (36%), left posterior putamen (18%), and left caudate nucleus (12%) of the patients than in the comparison subjects.	Positive