Study Report
Reference
| Citation | Kano, 2004 PubMed |
| Full Info | Kano, M., Fukudo, S., Tashiro, A., Utsumi, A., Tamura, D., Itoh, M., Iwata, R., Tashiro, M., Mochizuki, H., Funaki, Y. et al. (2004) Decreased histamine H1 receptor binding in the brain of depressed patients. Eur J Neurosci, 20, 803-810.
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Study
| Hypothesis or Background |
The central histaminergic neuron system modulates the wakefulness, sleep-awake cycle, appetite control, learning and memory, and emotion. Previous studies have reported changes in neuronal histamine release and its metabolism under stress conditions in the mammalian brain.
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| Sample Information | 10 patients with major depression and in 10 normal age-matched subjects |
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| Method Detail | In this study, we examined, using positron emission tomography (PET) and [(11)C]-doxepin, whether the histaminergic neuron system is involved in human depression. Cerebral histamine H1 receptor (H(1)R) binding was measured in 10 patients with major depression and in 10 normal age-matched subjects using PET and [(11)C]-doxepin. Data were calculated by a graphical analysis on voxel-by-voxel and ROI (region of interests) basis |
| Method Keywords | positron emission tomography (PET) |
| Result | Binding potential (BP) values for [(11)C]-doxepin binding in the frontal and prefrontal cortices, and cingulate gyrus were significantly lower in the depressed patients than those in the normal control subjects. There was no area of the brain where [(11)C]-doxepin binding was significantly higher in the depressed patients than in the controls. ROI-based analysis also revealed that BP values for [(11)C]-doxepin binding in the frontal cortex and cingulate gyrus decreased in proportion to self-rating depressive scales scores. |
| Conclusions | The results of this study demonstrate that depressed patients have decreased brain H(1)R binding and that this decrease correlates with the severity of depression symptoms. It is therefore suggested that the histaminergic neuron system plays an important role in the pathophysiology of depression and that its modulation may prove to be useful in the treatment of depression. |
Relationships reported by
Kano, 2004
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
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MDD
|
syndrome |
Frontal Lobe (frontal cortices) |
brain morphology and function |
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Binding (histamine H1 receptor (H(1)R) binding) potential values for [(11)C]-doxepin binding in the frontal and prefrontal cortices, and cingulate gyrus were significantly lower in the depressed patients than those in the normal control subjects. |
Positive
|
|
MDD
|
syndrome |
Cingulate gyrus (cingulate gyrus) |
brain morphology and function |
|
Binding (histamine H1 receptor (H(1)R) binding) potential values for [(11)C]-doxepin binding in the frontal and prefrontal cortices, and cingulate gyrus were significantly lower in the depressed patients than those in the normal control subjects. |
Positive
|
|
MDD
|
syndrome |
Histamine H1 receptor (histamine H1 receptor) |
protein |
|
Binding (histamine H1 receptor (H(1)R) binding) potential values for [(11)C]-doxepin binding in the frontal and prefrontal cortices, and cingulate gyrus were significantly lower in the depressed patients than those in the normal control subjects. |
Positive
|
|
MDD
|
syndrome |
Prefrontal cortex (prefrontal cortices) |
brain morphology and function |
|
Binding (histamine H1 receptor (H(1)R) binding) potential values for [(11)C]-doxepin binding in the frontal and prefrontal cortices, and cingulate gyrus were significantly lower in the depressed patients than those in the normal control subjects. |
Positive
|
