Study Report

CitationJanssen, 2004 PubMed
Full InfoJanssen, J., Hulshoff Pol, H.E., Lampe, I.K., Schnack, H.G., de Leeuw, F.E., Kahn, R.S. and Heeren, T.J. (2004) Hippocampal changes and white matter lesions in early-onset depression. Biol Psychiatry, 56, 825-831.

Hypothesis or Background Hippocampal volume reduction and increased prevalence of subcortical white matter lesions have been reported in late-life depression. We aimed to examine whether total number of subcortical white matter lesions were associated with reduced hippocampal volume in aged female subjects with early-onset depression (< 45 years) and healthy comparison subjects.
Sample InformationThe study included 28 middle-aged and elderly subjects with major depression and 41 age-matched control subjects.
Method DetailHippocampal, parahippocampal gyrus, and orbitofrontal cortex volumes were determined using manual tracing methods. White matter lesions were rated from T2-weighted MRI scans using a semiquantitative classification scale.
Method Keywordsmagnetic resonance imaging (MRI)
ResultAfter controlling for total brain volume and age, patients had reduced hippocampal volume due to right hippocampal volume decrease (2.84 mL vs. 3.12 mL, F = 16.6, p < .001). Parahippocampal and orbitofrontal volumes did not differ significantly between groups. Multiple linear regression analysis indicated that reduced hippocampal volume did not significantly correlate with total number of subcortical white matter lesions (t = .673, p = .518).
ConclusionsRight hippocampal volume was reduced in aged female early-onset subjects with depression. Total number of subcortical white matter lesions was not associated with the decrease in right hippocampal volume. Our data suggest hippocampal involvement, independent of subcortical white matter lesions, in the neuropathology of early-onset depression.

Relationships reported by Janssen, 2004