Study Report
Reference
| Citation | Wu, 2011 PubMed |
| Full Info | Wu, F., Tang, Y., Xu, K., Kong, L., Sun, W., Wang, F., Kong, D., Li, Y. and Liu, Y. (2011) Whiter matter abnormalities in medication-naive subjects with a single short-duration episode of major depressive disorder. Psychiatry Res, 191, 80-83.
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Study
| Hypothesis or Background |
Convergent studies have implicated white matter abnormalities in the pathophysiology of major depressive disorder (MDD).
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| Sample Information | 23 single-episode, medication-naive MDD participants versus 21 healthy control participants |
|---|
| Method Detail | In this study, diffusion tensor imaging (DTI) was used to examine white matter abnormalities in 23 single-episode, medication-naive MDD participants versus 21 healthy control participants. Voxel-based analysis was used to investigate whole brain white matter abnormalities in the MDD group. |
| Method Keywords | diffusion tensor imaging (DTI) |
| Result | Fractional anisotropy was significantly lower and apparent diffusion coefficient was significantly higher in the right superior longitudinal fasciculus (SLF) within the frontal lobe, right middle frontal and left parietal white matter in the MDD group compared with the healthy group. |
Relationships reported by
Wu, 2011
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
MDD
|
syndrome |
Frontal Lobe (frontal lobe) |
brain morphology and function |
|
Fractional anisotropy was significantly lower and apparent diffusion coefficient was significantly higher in the right superior longitudinal fasciculus (SLF) within the frontal lobe, right middle frontal and left parietal white matter in the MDD group compared with the healthy group. |
Positive
|
|
MDD
|
syndrome |
White matter (white matter) |
brain morphology and function |
|
Fractional anisotropy was significantly lower and apparent diffusion coefficient was significantly higher in the right superior longitudinal fasciculus (SLF) within the frontal lobe, right middle frontal and left parietal white matter in the MDD group compared with the healthy group. |
Positive
|
|
MDD
|
syndrome |
right medial frontal cortex (right middle frontal region) |
brain morphology and function |
|
Fractional anisotropy was significantly lower and apparent diffusion coefficient was significantly higher in the right superior longitudinal fasciculus (SLF) within the frontal lobe, right middle frontal and left parietal white matter in the MDD group compared with the healthy group. |
Positive
|
|
MDD
|
syndrome |
left parietal cortex (left parietal region) |
brain morphology and function |
|
Fractional anisotropy was significantly lower and apparent diffusion coefficient was significantly higher in the right superior longitudinal fasciculus (SLF) within the frontal lobe, right middle frontal and left parietal white matter in the MDD group compared with the healthy group. |
Positive
|
