Study Report
Reference
| Citation | Parsey, 2006 PubMed |
| Full Info | Parsey, R.V., Hastings, R.S., Oquendo, M.A., Huang, Y.Y., Simpson, N., Arcement, J., Huang, Y., Ogden, R.T., Van Heertum, R.L., Arango, V. et al. (2006) Lower serotonin transporter binding potential in the human brain during major depressive episodes. Am J Psychiatry, 163, 52-58.
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Study
| Hypothesis or Background |
CSF analysis, neuroendocrine challenges, serotonin depletion studies, and treatment studies implicate the serotonergic system in the pathophysiology of major depressive disorder. On the basis of postmortem and imaging studies, the authors hypothesized that subjects with major depressive disorder in a major depressive episode have fewer serotonin transporter sites, compared with healthy subjects.
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| Sample Information | 25 medication-free subjects with DSM-IV major depressive disorder during a major depressive episode and in 43 healthy volunteer comparison subjects |
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| Method Detail | Serotonin transporter binding potential (f(1)B(max)/K(d)) was determined using positron emission tomography with [(11)C]McN 5652 in six brain regions in 25 medication-free subjects with DSM-IV major depressive disorder during a major depressive episode and in 43 healthy volunteer comparison subjects. All subjects had arterial lines placed to determine metabolite-corrected arterial input functions. |
| Method Keywords | positron emission tomography (PET) |
| Result | Serotonin transporter binding potential differed significantly by brain region and group. Post hoc analysis revealed lower binding potential in subjects with major depressive disorder, relative to the comparison subjects, in the amygdala and midbrain. The lower binding potential was more pronounced in the depressed subjects who had never received antidepressants. No correlation was found between binding potential in the midbrain and severity of depression or number of days without medication. Binding potential did not differ between suicide attempters and nonattempters. |
| Conclusions | Subjects in a major depressive episode have lower serotonin transporter binding potential in the amygdala and midbrain, compared to healthy subjects. |
Relationships reported by
Parsey, 2006
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
MDD
|
syndrome |
Sodium-dependent serotonin transporter (serotonin transporter) |
protein |
|
Post hoc analysis revealed lower binding potential(serotonin transporter binding potential) in subjects with major depressive disorder, relative to the comparison subjects. The lower binding potential was more pronounced in the depressed subjects who had never received antidepressants. |
Positive
|
|
Midbrain (midbrain)
|
brain morphology and function |
Sodium-dependent serotonin transporter (serotonin transporter) |
protein |
|
Post hoc analysis revealed lower binding potential(serotonin transporter binding potential) in subjects with major depressive disorder, relative to the comparison subjects, in the midbrain. |
Positive
|
|
Amygdala (amygdala)
|
brain morphology and function |
Sodium-dependent serotonin transporter (serotonin transporter) |
protein |
|
Post hoc analysis revealed lower binding potential(serotonin transporter binding potential) in subjects with major depressive disorder, relative to the comparison subjects, in the amygdala |
Positive
|
|
MDD
|
syndrome |
Midbrain (midbrain) |
brain morphology and function |
|
Post hoc analysis revealed lower binding potential(serotonin transporter binding potential) in subjects with major depressive disorder, relative to the comparison subjects, in the midbrain. |
Positive
|
|
MDD
|
syndrome |
Amygdala (amygdala) |
brain morphology and function |
|
Post hoc analysis revealed lower binding potential(serotonin transporter binding potential) in subjects with major depressive disorder, relative to the comparison subjects, in the amygdala |
Positive
|
|
Depressed mood (depression)
|
symptoms |
Midbrain (midbrain) |
brain morphology and function |
|
No correlation was found between binding potential in the midbrain and severity of depression or number of days without medication. |
Negative
|
