Study Report
Reference
| Citation | Shi, 2010 PubMed |
| Full Info | Shi, Y., You, J., Yuan, Y., Zhang, X., Li, H. and Hou, G. (2010) Plasma BDNF and tPA are associated with late-onset geriatric depression. Psychiatry Clin Neurosci, 64, 249-254.
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Study
| Hypothesis or Background |
Studies in the recent decade have shown that brain-derived neurotrophic factor (BDNF) may play an important role in the pathogenesis of major depressive disorder (MDD). Tissue-type plasminogen activator (tPA) has been implicated in the control of the direction of BDNF action. The aim of the study was therefore to investigate the changes of BDNF/tPA levels and their clinical meanings in geriatric depression.
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| Sample Information | late-onset geriatric depression (LGD) before treatment (n = 24) and after 6 weeks of antidepressant treatment (n = 24) compared with control subjects (n = 30) |
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| Method Detail | Plasma BDNF and tPA levels were measured in late-onset geriatric depression (LGD) before treatment (n = 24) and after 6 weeks of antidepressant treatment (n = 24) compared with control subjects (n = 30) using enzyme-linked immunosorbent assay. The severity of depression was assessed with the Hamilton Depression Rating Scale. |
| Method Keywords | blood analysis |
| Result | Baseline plasma BDNF and tPA levels were significantly lower in LGD patients compared to controls (P = 0.037 and P = 0.000, respectively). There was a heightening tendency of plasma BDNF level after treatment. |
| Conclusions | Plasma BDNF and tPA levels are associated with LGD. The complex mechanism of BDNF and tPA in LGD should be further explored in future studies. |
Relationships reported by
Shi, 2010
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
MDD
|
syndrome |
Tissue-type plasminogen activator (tissue-type plasminogen activator (tPA)) |
protein |
P-value = 0.000 |
Baseline plasma BDNF and tPA levels were significantly lower in LGD(late-onset geriatric depression) patients compared to controls (P = 0.037 and P = 0.000, respectively). |
Positive
|
|
MDD
|
syndrome |
Brain-derived neurotrophic factor (brain-derived neurotrophic factor (BDNF)) |
protein |
P-value = 0.037 |
Baseline plasma BDNF and tPA levels were significantly lower in LGD(late-onset geriatric depression) patients compared to controls (P = 0.037 and P = 0.000, respectively). There was a heightening tendency of plasma BDNF level after treatment. |
Positive
|
