Gene Report

Basic Information

Approved Symbol	NQO1
Approved Name	NAD(P)H dehydrogenase, quinone 1
Previous Symbol	NMOR1, DIA4
Previous Name	diaphorase (NADH/NADPH) (cytochrome b-5 reductase)
Symbol Alias	DHQU, QR1, DTD
Location	16q12-q22
Position	chr16:69743304-69760533 (-)
External Links	Entrez Gene: 1728 Ensembl: ENSG00000181019 UCSC: uc002exp.3 HGNC ID: 2874
No. of Studies (Positive/Negative)	1(0/1)
Type	Literature-origin

Positive relationships between NQO1 and MDD (count: 0)

Positive relationships between NQO1 and other components at different levels (count: 0)

Positive relationship network of NQO1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between NQO1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
NQO1	Pae CU, 2007	Patients and nomal controls		Case-control association study of the possible relationship ...... Case-control association study of the possible relationship between the NQO1 gene polymorphism and mood disorders (patients with major depressive disorder, n=61; patients with bipolar I disorder, n=80; control, n=106) was carried out using PCR-based techniques. These preliminary results showed that the NQO1 gene polymorphism was not related to a susceptibility to mood disorders. More...

Negative relationships between NQO1 and other components at different levels (count: 0)

NQO1 related SNPs in MK4MDD (count: 0)

NQO1 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
NAD(P)H dehydrogenase [quinone] 1	P15559	0(0/0)	Gene mapped

NQO1 related GO terms (count: 22)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0006521	regulation of cellular amino acid metabolic process	biological process	TAS
GO:0043025	neuronal cell body	cellular component	IEA
GO:0007568	aging	biological process	IEA
GO:0007584	response to nutrient	biological process	IEA
GO:0005737	cytoplasm	cellular component	IDA
GO:0005829	cytosol	cellular component	TAS
GO:0006801	superoxide metabolic process	biological process	IEA
GO:0007271	synaptic transmission, cholinergic	biological process	TAS[9579781]
GO:0003955	NAD(P)H dehydrogenase (quinone) activity	molecular function	IEA
GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H	molecular function	TAS[9579781]
GO:0043086	negative regulation of catalytic activity	biological process	IEA
GO:0006979	response to oxidative stress	biological process	IEA
GO:0006805	xenobiotic metabolic process	biological process	TAS[10393963]
GO:0004784	superoxide dismutase activity	molecular function	IEA
GO:0045471	response to ethanol	biological process	IEA
GO:0005515	protein binding	molecular function	IPI
GO:0034641	cellular nitrogen compound metabolic process	biological process	TAS
GO:0043525	positive regulation of neuron apoptotic process	biological process	IEA
GO:0006809	nitric oxide biosynthetic process	biological process	TAS[9579781]
GO:0044281	small molecule metabolic process	biological process	TAS
GO:0009636	response to toxin	biological process	TAS[10393963]
GO:0032355	response to estradiol stimulus	biological process	IEA

NQO1 related KEGG pathways (count: 0)

NQO1 related BioCarta pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped BioCarta pathways
P53HYPOXIA_PATHWAY	p53hypoxia pathway	Hypoxia and p53 in the Cardiovascular system	Hypoxic stress, like DNA damage, induces p53 protein accumul...... Hypoxic stress, like DNA damage, induces p53 protein accumulation and p53-dependent apoptosis in oncogenically transformed cells. Unlike DNA damage, hypoxia does not induce p53-dependent cell cycle arrest, suggesting that p53 activity is differentially regulated by these two stresses. Hypoxia induces p53 protein accumulation, but in contrast to DNA damage, hypoxia fails to induce endogenous downstream p53 effector mRNAs and proteins, such as p21, Bax, CIP1, WAF1 etc. Hypoxia does not inhibit the induction of p53 target genes by ionizing radiation, indicating that p53-dependent transactivation requires a DNA damage-inducible signal that is lacking under hypoxic treatment alone. The phosphatidylinositol 3-OH-kinase-Akt pathway inhibits p53-mediated transcription and apoptosis. Mdm2, a ubiquitin ligase for p53, plays a central role in regulation of the stability of p53 and serves as a good substrate for Akt. Mdm-2 targets the p53 tumor suppressor for ubiquitin-dependent degradation by the proteasome, but, in addition, the p53 transcription factor induces Mdm-2, thus, establishing a feedback loop. Hypoxia or DNA damage by abrogating binding of HIF-1 with VHL and p53 with Mdm-2, respectively, leads to stabilization and accumulation transcriptionally active HIF-1 and p53. At the molecular level, DNA damage induces the interaction of p53 with the transcriptional activator p300 as well as with the transcriptional corepressor mSin3A. In contrast, hypoxia primarily induces an interaction of p53 with mSin3A, but not with p300. More...

NQO1 related Reactome pathways (count: 2)

ID	Name	Description
Gene mapped Reactome pathways
REACT_13	metabolism of_amino_acids	This group of reactions is responsible for: 1) the breakdown...... This group of reactions is responsible for: 1) the breakdown of amino acids; 2) the synthesis of urea from ammonia and amino groups generated by amino acid breakdown; 3) the synthesis of the ten amino acids that are not essential components of the human diet; and 4) the synthesis of related nitrogen-containing molecules including carnitine and creatine. More...
REACT_13565	regulation of_ornithine_decarboxylase	Polyamines increase the production of antizyme. The followin...... Polyamines increase the production of antizyme. The following illustration is adapted from a minireview by Pegg, 2006; J. Biol. Chem., Vol. 281, Issue 21, 14529-14532. More...

NQO1 related interactors from protein-protein interaction data in HPRD (count: 5)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
NQO1	ING1	No	in vivo	18388957
NQO1	HSPA1A	No	in vitro	11821413
NQO1	NQO1	Yes	in vitro	10543876
NQO1	DNAJB1	No	in vitro;in vivo	11821413
NQO1	TP53	No	in vivo	12529318

Gene Report

Gene mapped GO terms

Gene mapped BioCarta pathways

Gene mapped Reactome pathways