Gene Report

Basic Information

Approved Symbol	CFB
Approved Name	complement factor B
Previous Symbol	BFD, BF
Previous Name	"B-factor, properdin"
Symbol Alias	H2-Bf
Location	6p21.3
Position	chr6:31919808-31919861 (+)
External Links	Entrez Gene: 629 UCSC: uc011dor.2 HGNC ID: 1037
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between CFB and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
properdin factor B	Fieve, 1984	patients and normal controls		Using 28 blood group markers, a prior association study betw...... Using 28 blood group markers, a prior association study between the trait defining susceptibility to affective disorder and the genetic marker was positive for haptoglobin GC, and properdinfactor B, confirming earlier findings. More...

Positive relationships between CFB and other components at different levels (count: 0)

Positive relationship network of CFB in MK4MDD

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between CFB and MDD (count: 0)

Negative relationships between CFB and other components at different levels (count: 0)

CFB related SNPs in MK4MDD (count: 0)

CFB related proteins in MK4MDD (count: 0)

CFB related GO terms (count: 12)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0045087	innate immune response	biological process	TAS
GO:0070062	extracellular exosome	cellular component	IDA[23376485\|23533145]
GO:0006956	complement activation	biological process	TAS
GO:0005886	plasma membrane	cellular component	TAS
GO:0030449	regulation of complement activation	biological process	TAS
GO:0005615	extracellular space	cellular component	IDA[16502470]
GO:0006957	complement activation, alternative pathway	biological process	NAS[8225386]; TAS
GO:0004252	serine-type endopeptidase activity	molecular function	TAS
GO:0006508	proteolysis	biological process	IEA
GO:0072562	blood microparticle	cellular component	IDA[22516433]
GO:0005576	extracellular region	cellular component	TAS
GO:0001848	complement binding	molecular function	TAS[11367526]

CFB related KEGG pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04610	complement and_coagulation_cascades	Complement and coagulation cascades	Blood coagulation is a series of coordinated and calcium-dep...... Blood coagulation is a series of coordinated and calcium-dependent proenzyme-to-serine protease conversions likely to be localized on the surfaces of activated cells in vivo. It culminates in the formation of thrombin, the enzyme responsible for the conversion of soluble fibrinogen to the insoluble fibrin clot. The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results in the release of vasoactive kinins (bradykinin-related peptides). Kinin peptides are implicated in many physiological and pathological processes including the regulation of blood pressure and sodium homeostasis, inflammatory processes, and the cardioprotective effects of preconditioning. Complement is a system of plasma proteins that is activated by the presence of pathogens. There are three pathways of complement activation: the classical pathway, the lectin pathway, and the alternative pathway. All of these pathways generate a crucial enzymatic activity that, intern, generates the effector molecules of complement. The three main consequences of complement activation are the opsonization of pathogens, the recruitment of inflammatory and immunocompetent cells, and the direct killing of pathogens. More...

CFB related BioCarta pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped BioCarta pathways
COMP_PATHWAY	comp pathway	Complement Pathway	The complement pathway consists of a series of over thirty p...... The complement pathway consists of a series of over thirty proteins in plasma that are part of the immune response. Activation of the complement system lyses bacterial cells, forms chemotactic peptides (C3a and C5a) attracting immune cells, and increases phagocytotic clearance of infecting cells. Complement can also increase the permeability of vascular walls and cause inflammation. Most complement proteins exist in plasma as inactive precursors that cleave and activate each other in a proteolytic cascade in response to three different mechanisms by which the complement system is activated, the classical pathway, the alternative pathway and the lectin-induced pathway. These three systems are distinct in the initiation of the proteolytic cascade but share most of their components and all three converge in the creation of a C3 convertase that cleaves the C3 complement protein, leading ultimately to the formation of the membrane attack complex, MAC, a pore causing lysis of cells. The classical pathway is activated by the recognition of foreign cells by antibodies bound to the surface of the cells. The alternative and lectin-induced pathways are both antibody independent. Proteolysis is triggered in the alternative pathway by the spontaneous activation of C3 convertase from C3 and is triggered in the lectin-induced pathway by the recognition of carbohydrates on the bacterial cell surface by mannan-binding protein, Mbp. In addition to providing a key part of the response to bacterial infection, the complement system can be involved in the response to fungi, viruses and protists. While activation of the complement system is a key part of the immune system, it must also be kept in check to prevent inappropriate or exaggerated responses. Twelve different proteins have been identified that inhibit complement activation to control the system, including Factor H, Factor I and C1 inhibitor. Deficiencies in components of the complement system have been identified in humans that cause a variety of immune related disorders. C3 deficiency is associated with recurrent bacterial infections, while a lack of C2 can cause antibody-antigen complexes to accumulate and cause the autoimmune disorder systemic lupus erythematosus. People lacking C1 inhibitor have also been identified and found to be prone to uncontrolled complement activation and dangerous swelling through production of C3a and C5a anaphylotoxins. More...

CFB related Reactome pathways (count: 4)

ID	Name	Description
Gene mapped Reactome pathways
REACT_6802	innate immunity_signaling	Innate immunity encompases the nonspecific part of immunity ...... Innate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup More...
REACT_8024	initial triggering_of_complement	Complement activation is due to a cascade of proteolytic ste...... Complement activation is due to a cascade of proteolytic steps, performed by serine protease domains in some of the components. Three different pathways of activation are distinguished triggered by target-bound antibody (the classical pathway); microbial polysaccharide structures (the lectin pathway); or recognition of other foreign surface structures (the alternative pathway) by C3b. All three merge in the pivotal activation of C3 and, subsequently, of C5 by highly specific enzymatic complexes, the so-called C3/C5 convertases. A complement system with three C3 activation pathways and a common lytic pathway is found only in jawed vertebrates. More...
REACT_6900	signaling in_immune_system	Humans are exposed to millions of potential pathogens daily,...... Humans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first critical hours and days of exposure to a new pathogen, our innate immune system. More...
REACT_6932	complement cascade

CFB related interactors from protein-protein interaction data in HPRD (count: 3)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
CFB	C3	No	in vitro	10610782 , 8648130 , 11367533
CFB	CFP	No	in vitro	3140783 , 10861231
CFB	C4B	No	in vitro	11341920

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped BioCarta pathways

Gene mapped Reactome pathways