Gene Report

Basic Information

Approved Symbol	SV2B
Approved Name	synaptic vesicle glycoprotein 2B
Symbol Alias	KIAA0735, HsT19680
Location	15q26.1
Position	chr15:91643182-91844539 (+)
External Links	Entrez Gene: 9899 Ensembl: ENSG00000185518 UCSC: uc002bqv.3 HGNC ID: 16874
No. of Studies (Positive/Negative)	2(2/0)
Type	Literature-origin

Positive relationships between SV2B and MDD (count: 2)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
SV2B	Verma, 2008	patients and normal controls		LD mapping showed nominally significant association in NTRK3...... LD mapping showed nominally significant association in NTRK3, FLJ12484, RHCG, DKFZp547K1113, VPS33B, SV2B, SLCO3A1, RGMA, and MCTP2 with MDD-RE More...
SV2B	Sequeira, 2007	patients and normal controls		Selected differentially expressed genes in hippocampus Selected differentially expressed genes in hippocampus

Positive relationships between SV2B and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
SV2B		Hippocampus(hippocampus)	brain morphology and function	Sequeira, 2007	patients and normal controls		Selected differentially expressed genes in hippocampus Selected differentially expressed genes in hippocampus

Positive relationship network of SV2B in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between SV2B and MDD (count: 0)

Negative relationships between SV2B and other components at different levels (count: 0)

SV2B related SNPs in MK4MDD (count: 0)

SV2B related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Synaptic vesicle glycoprotein 2B	Q7L1I2	0(0/0)	Gene mapped

SV2B related GO terms (count: 6)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0030054	cell junction	cellular component	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0022857	transmembrane transporter activity	molecular function	IEA
GO:0001669	acrosomal vesicle	cellular component	IEA
GO:0016021	integral to membrane	cellular component	IEA
GO:0006836	neurotransmitter transport	biological process	IEA
GO:0030672	synaptic vesicle membrane	cellular component	IEA

SV2B related KEGG pathways (count: 1)

ID	Name	Brief Description	Full Description
Literature-origin KEGG pathway
hsa04512	ecm receptor_interaction	ECM-receptor interaction	The extracellular matrix (ECM) consists of a complex mixture...... The extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell and tissue structure and function. Specific interactions between cells and the ECM are mediated by transmembrane molecules, mainly integrins and perhaps also proteoglycans, CD36, or other cell-surface-associated components. These interactions lead to a direct or indirect control of cellular activities such as adhesion, migration, differentiation, proliferation, and apoptosis. In addition, integrins function as mechanoreceptors and provide a force-transmitting physical link between the ECM and the cytoskeleton. Integrins are a family of glycosylated, heterodimeric transmembrane adhesion receptors that consist of noncovalently bound alpha- and beta-subunits. More...

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways

SV2B related BioCarta pathways (count: 0)

SV2B related Reactome pathways (count: 0)

SV2B related interactors from protein-protein interaction data in HPRD (count: 1)

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Literature-origin KEGG pathway

Gene mapped KEGG pathways