Gene Report

Basic Information

Approved Symbol	GPNMB
Approved Name	glycoprotein (transmembrane) nmb
Symbol Alias	NMB, HGFIN
Name Alias	transmembrane glycoprotein, "glycoprotein NMB", "glycoprotein nmb-like protein", "osteoactivin"
Location	7p
Position	chr7:23286316-23314729 (+)
External Links	Entrez Gene: 10457 Ensembl: ENSG00000136235 UCSC: uc003swb.3 HGNC ID: 4462
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between GPNMB and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
GPNMB	Sibille E, 2009	animal model; patients and nomal controls	R=0.88, P-value<5E-6; y slope=1.11	Upregulated in MDD patients Upregulated in MDD patients

Positive relationships between GPNMB and other components at different levels (count: 0)

Positive relationship network of GPNMB in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between GPNMB and MDD (count: 0)

Negative relationships between GPNMB and other components at different levels (count: 0)

GPNMB related SNPs in MK4MDD (count: 0)

GPNMB related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Transmembrane glycoprotein NMB	Q14956	0(0/0)	Gene mapped

GPNMB related GO terms (count: 9)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0008285	negative regulation of cell proliferation	biological process	TAS[7814155]
GO:0001649	osteoblast differentiation	biological process	IEA
GO:0030282	bone mineralization	biological process	IEA
GO:0005178	integrin binding	molecular function	IEA
GO:0008201	heparin binding	molecular function	IEA
GO:0007155	cell adhesion	biological process	IEA
GO:0042470	melanosome	cellular component	IEA
GO:0005887	integral to plasma membrane	cellular component	IEA
GO:0016021	integral to membrane	cellular component	TAS[7814155]

GPNMB related KEGG pathways (count: 0)

GPNMB related BioCarta pathways (count: 0)

GPNMB related Reactome pathways (count: 0)

GPNMB related interactors from protein-protein interaction data in HPRD (count: 1)

Gene Report

Gene mapped GO terms