Gene Report

Basic Information

Approved Symbol	ROBO2
Approved Name	roundabout, axon guidance receptor, homolog 2 (Drosophila)
Previous Name	roundabout (axon guidance receptor, Drosophila) homolog 2
Symbol Alias	KIAA1568
Location	3p12.3
Position	chr3:75955845-77699115 (+)
External Links	Entrez Gene: 6092 Ensembl: ENSG00000185008 UCSC: uc003dpy.4 HGNC ID: 10250
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between ROBO2 and MDD (count: 0)

Positive relationships between ROBO2 and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
Robo2		Histone-lysine N-methyltransferase SETDB1(Setdb1 (Set domain, bifurcated 1))	protein	Jiang Y, 2010	animal model		Gene was occupied by Setdb1 in neuron Gene was occupied by Setdb1 in neuron

Positive relationship network of ROBO2 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between ROBO2 and MDD (count: 0)

Negative relationships between ROBO2 and other components at different levels (count: 0)

ROBO2 related SNPs in MK4MDD (count: 0)

ROBO2 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Roundabout homolog 2	Q9HCK4	0(0/0)	Gene mapped

ROBO2 related GO terms (count: 21)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0007411	axon guidance	biological process	ISS; TAS
GO:0032870	cellular response to hormone stimulus	biological process	IEP[18566128]
GO:0009986	cell surface	cellular component	IDA[12504588]
GO:0007156	homophilic cell adhesion	biological process	IDA[12504588]
GO:0050772	positive regulation of axonogenesis	biological process	IDA[12504588]
GO:0021891	olfactory bulb interneuron development	biological process	ISS
GO:0030673	axolemma	cellular component	ISS
GO:0061364	apoptotic process involved in luteolysis	biological process	IEP[18566128]
GO:0042802	identical protein binding	molecular function	IDA[12504588]
GO:0031290	retinal ganglion cell axon guidance	biological process	ISS
GO:0008046	axon guidance receptor activity	molecular function	ISS; NAS[9458045]
GO:0001657	ureteric bud development	biological process	IMP[17357069]
GO:0016199	axon midline choice point recognition	biological process	ISS
GO:0007417	central nervous system development	biological process	NAS[9458045]
GO:0001656	metanephros development	biological process	ISS
GO:0016021	integral to membrane	cellular component	IEA
GO:0046982	protein heterodimerization activity	molecular function	IEA
GO:0005515	protein binding	molecular function	IPI[15207848]
GO:0050925	negative regulation of negative chemotaxis	biological process	IDA[11748139]
GO:0007420	brain development	biological process	IEP[10197527]
GO:0051964	negative regulation of synapse assembly	biological process	ISS

ROBO2 related KEGG pathways (count: 1)

ID	Name	Brief Description	Full Description
Literature-origin KEGG pathway
hsa04360	axon guidance	Axon guidance	Axon guidance represents a key stage in the formation of neu...... Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn. More...

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways

ROBO2 related BioCarta pathways (count: 0)

ROBO2 related Reactome pathways (count: 2)

ID	Name	Description
Gene mapped Reactome pathways
REACT_18266	axon guidance	Axon guidance / axon pathfinding is the process by which neu...... Axon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, which senses the guidance cues in the environment through guidance cue receptors and responds by undergoing cytoskeletal changes that determine the direction of axon growth. Guidance cues present in the surrounding environment provide the necessary directional information for the trip. These extrinsic cues have been divided into attractive or repulsive signals that tell the growth cone where and where not to grow. Genetic and biochemical studies have led to the identification of highly conserved families of guidance molecules and their receptors that guide axons. These include netrins, Slits, semaphorins, and ephrins, and their cognate receptors, DCC and or uncoordinated-5 (UNC5), roundabouts (Robo), neuropilin and Eph. In addition, many other classes of adhesion molecules are also used by growth cones to navigate properly which include NCAM and L1CAM. More...
REACT_19351	signaling by_robo_receptor	The Roundabout (Robo) family encodes transmembrane receptors...... The Roundabout (Robo) family encodes transmembrane receptors that regulate axonal guidance and cell migration. The major function of the Robo receptors is to mediate repulsion of the navigating growth cones. There are four human Robo homologues, Robo1, Robo2, Robo3 and Robo4. Most of the Robos have the similar ectodomain architecture as the cell adhesion molecules, five Ig domains followed by three FN3 repeats except for Robo4, it has 2Ig and 2FN3 repeats. The cytoplasmic domains of Robo receptors are in general poorly conserved. However, there are four short conserved cytoplasmic sequence motifs, named CC0-3, that serve as binding sites for adaptor proteins. The ligands for the human Robo receptors are the three Slit proteins Slit1, Slit2, and Slit3; all of the Slit proteins contain a tandem of four LRR (leucine rich repeat) domains at N terminus, termed D1 D4 followed by six EGF (epidermal growth factor)-like domains, a laminin G like domain (ALPS), three EGF-like domains, and a C-terminal cysteine knot domain. Most Slit proteins are cleaved within the EGF-like region by unknown proteases. Slit protein binding modulates Robo interactions with the cytosolic adaptors. The cytoplasmic domain of Robo1 and Robo2 determines the repulsive responses of these receptors. Based on the studies from both invertebrate and vertebrate organisms its been inferred that Robo induces growth cone repulsion by controlling cytoskeletal dynamics via either Abelson kinase (Abl) and Enabled (Ena), or Rac activity. More...

ROBO2 related interactors from protein-protein interaction data in HPRD (count: 8)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
ROBO2	SSRP1	No	yeast 2-hybrid	16169070
ROBO2	CPE	No	yeast 2-hybrid	16169070
ROBO2	SLIT3	Yes	in vitro;in vivo	11754167
ROBO2	SLIT2	No	in vitro	10102268
ROBO2	PPP1R1B	No	yeast 2-hybrid	16169070
ROBO2	UBQLN4	No	yeast 2-hybrid	16713569
ROBO2	OLFM2	No	yeast 2-hybrid	16169070
ROBO2	ROBO1	No	in vitro	12504588

Gene Report

Gene mapped GO terms

Literature-origin KEGG pathway

Gene mapped KEGG pathways

Gene mapped Reactome pathways