Gene Report

Basic Information

Approved Symbol	RYK
Approved Name	receptor-like tyrosine kinase
Previous Symbol	JTK5A
Previous Name	"JTK5A protein tyrosine kinase", "RYK receptor-like tyrosine kinase"
Symbol Alias	D3S3195, RYK1, JTK5
Location	3q22.1
Position	chr3:133969497-133969586 (-)
External Links	Entrez Gene: 6259 Ensembl: ENSG00000163785 UCSC: uc003eqc.1 HGNC ID: 10481
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between RYK and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
RYK receptor-like tyrosine kinase	Tochigi, 2008	patients and normal controls		Genes differentially expressed in major depression Genes differentially expressed in major depression

Positive relationships between RYK and other components at different levels (count: 0)

Positive relationship network of RYK in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between RYK and MDD (count: 0)

Negative relationships between RYK and other components at different levels (count: 0)

RYK related SNPs in MK4MDD (count: 0)

RYK related proteins in MK4MDD (count: 0)

RYK related GO terms (count: 36)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0022008	neurogenesis	biological process	NAS[20004982]
GO:0030182	neuron differentiation	biological process	ISS

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0017147	Wnt-protein binding	molecular function	ISS; NAS[20004982]
GO:0005515	protein binding	molecular function	IPI[15454084]
GO:0060070	canonical Wnt signaling pathway	biological process	NAS[20004982]
GO:1904929	coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway	molecular function	TAS[24431302]
GO:0018108	peptidyl-tyrosine phosphorylation	biological process	TAS[8386829]
GO:0035567	non-canonical Wnt signaling pathway	biological process	NAS[20004982]
GO:0071679	commissural neuron axon guidance	biological process	ISS
GO:0004714	transmembrane receptor protein tyrosine kinase activity	molecular function	TAS[8386829]
GO:0016021	integral component of membrane	cellular component	NAS[8726462]
GO:1904948	midbrain dopaminergic neuron differentiation	biological process	ISS
GO:0004888	transmembrane signaling receptor activity	molecular function	IDA[10454588]
GO:1904953	Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation	biological process	ISS; TAS[24431302]
GO:0036518	chemorepulsion of dopaminergic neuron axon	biological process	ISS
GO:0007165	signal transduction	biological process	TAS[8386829]
GO:0007411	axon guidance	biological process	ISS; NAS[20004982]
GO:0005886	plasma membrane	cellular component	ISS; TAS
GO:0004713	protein tyrosine kinase activity	molecular function	IDA[10454588]
GO:0006468	protein phosphorylation	biological process	IDA[10454588]
GO:0005109	frizzled binding	molecular function	ISS; NAS[20004982]
GO:0007416	synapse assembly	biological process	NAS[20004982]
GO:0043410	positive regulation of MAPK cascade	biological process	IDA[10454588]
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0007409	axonogenesis	biological process	ISS; TAS[24431302]
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0005887	integral component of plasma membrane	cellular component	TAS[8386829]
GO:0022038	corpus callosum development	biological process	ISS
GO:0005737	cytoplasm	cellular component	ISS
GO:0033278	cell proliferation in midbrain	biological process	ISS
GO:0016020	membrane	cellular component	ISS
GO:1904938	planar cell polarity pathway involved in axon guidance	biological process	ISS
GO:0005634	nucleus	cellular component	ISS; NAS[20004982]
GO:0005524	ATP binding	molecular function	IEA
GO:0031175	neuron projection development	biological process	ISS
GO:0042813	Wnt-activated receptor activity	molecular function	ISS

RYK related KEGG pathways (count: 0)

RYK related BioCarta pathways (count: 0)

RYK related Reactome pathways (count: 0)

RYK related interactors from protein-protein interaction data in HPRD (count: 5)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
RYK	WNT1	No	in vitro	15454084
RYK	EPHB3	No	in vitro;in vivo	11956217
RYK	WNT3A	No	in vitro	15454084
RYK	EPHB2	No	in vivo	11956217
RYK	FZD8	No	in vivo	15454084

Gene Report

Literature-origin GO terms

Gene mapped GO terms