MK4MDD

Gene Report

Basic Information
Approved Symbol NOS2
Approved Name nitric oxide synthase 2, inducible
Previous Symbol NOS2A
Previous Name "nitric oxide synthase 2A (inducible, hepatocytes)"
Symbol Alias iNOS, NOS, HEP-NOS
Location 17q11.2-q12
Position chr17:26127365-26127555 (-)
External Links Entrez Gene: 4843
Ensembl: ENSG00000007171
UCSC: uc002gzu.3
HGNC ID: 7873
No. of Studies (Positive/Negative) 2(1/1) Help
Type Literature-origin

Positive relationships between NOS2 and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description Help
Nitric Oxide Synthase 2A (NOS2A) Schosser, 2011 patients and normal controls P-value=0.017, FDRP-value=0.026 In the combined sample of 2,170 MDD cases and 1,810 controls...... In the combined sample of 2,170 MDD cases and 1,810 controls, there were positive findings in the Nitric Oxide Synthase 2A (NOS2A) gene both using single SNP analysis and haplotype analysis. Haplotype analyses applying 2- and 3-SNPs sliding windows using UNPHASED program showed significant global association between NOS2A rs2297518¨Crs8072199¨Crs2779248 haplotype (P=0.017, FDRp=0.026) and MDD. More...

Positive relationships between NOS2 and other components at different levels (count: 0) Help
Positive relationship network of NOS2 in MK4MDD
Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between NOS2 and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description
NOS Yu YW, 2003 Patients and nomal controls The results demonstrate that the nNOS variants are found at ...... The results demonstrate that the nNOS variants are found at similar frequencies in MDD patients and healthy control subjects. More...

Negative relationships between NOS2 and other components at different levels (count: 0) Help
NOS2 related SNPs in MK4MDD (count: 0)
NOS2 related proteins in MK4MDD (count: 0)
NOS2 related GO terms (count: 51)
NOS2 related KEGG pathways (count: 6)
NOS2 related BioCarta pathways (count: 2)
NOS2 related Reactome pathways (count: 0)
NOS2 related interactors from protein-protein interaction data in HPRD (count: 8)