Gene Report

Basic Information

Approved Symbol	FZD9
Approved Name	frizzled class receptor 9
Previous Name	"frizzled (Drosophila) homolog 9", "frizzled homolog 9 (Drosophila)", "frizzled 9, seven transmembrane spanning receptor", "frizzled family receptor 9"
Symbol Alias	FZD3, CD349
Location	7q11.23
Position	chr7:72850114-72850450 (+)
External Links	Entrez Gene: 8326 Ensembl: ENSG00000188763 UCSC: uc003tyb.3 HGNC ID: 4047
No. of Studies (Positive/Negative)	1(0/1)
Type	Literature-origin

Positive relationships between FZD9 and MDD (count: 0)

Positive relationships between FZD9 and other components at different levels (count: 0)

Positive relationship network of FZD9 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between FZD9 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
FZD3	Hashimoto R, 2005	Patients and nomal controls		We failed to find significant association in the four SNPs o...... We failed to find significant association in the four SNPs or haplotype analysis More...

Negative relationships between FZD9 and other components at different levels (count: 0)

FZD9 related SNPs in MK4MDD (count: 0)

FZD9 related proteins in MK4MDD (count: 0)

FZD9 related GO terms (count: 18)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0016021	integral component of membrane	cellular component	IEA
GO:0007405	neuroblast proliferation	biological process	IEA
GO:0009986	cell surface	cellular component	IDA[20458727]
GO:0017147	Wnt-protein binding	molecular function	IPI[19038973]
GO:0042803	protein homodimerization activity	molecular function	IPI[14688793]
GO:0048471	perinuclear region of cytoplasm	cellular component	IEA
GO:0042813	Wnt-activated receptor activity	molecular function	IEA
GO:0060070	canonical Wnt signaling pathway	biological process	IBA
GO:0046982	protein heterodimerization activity	molecular function	IPI[14688793]
GO:0007186	G-protein coupled receptor signaling pathway	biological process	IEA
GO:0035567	non-canonical Wnt signaling pathway	biological process	IBA
GO:0031527	filopodium membrane	cellular component	IEA
GO:0004930	G-protein coupled receptor activity	molecular function	IBA
GO:0007399	nervous system development	biological process	TAS[9147651]
GO:0030183	B cell differentiation	biological process	IEA
GO:0005737	cytoplasm	cellular component	IDA[19038973\|20458727]
GO:0007611	learning or memory	biological process	IEA
GO:0005886	plasma membrane	cellular component	IDA[19038973]

FZD9 related KEGG pathways (count: 4)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa05217	basal cell_carcinoma	Basal cell carcinoma	The development of basal cell carcinoma is associated with c...... The development of basal cell carcinoma is associated with constitutive activation of sonic hedgehog signaling. Normally, ligand-dependent signaling by Hedgehog (Hh) homologs proceeds through binding to the Patched receptor. This binding relieves the Patched-mediated inhibition of signaling through the Smoothened (SMOH) gene product. This signaling ultimately results in the dissociation of the Gli1 transcription factor from an inhibitory complex in the cytoplasm, its subsequent translocation to the nucleus, and activation of target gene expression. The mutations in SMOH, PTCH1, and SHH in BCCs result in continuous activation of target genes. At a cellular level, sonic hedgehog signaling promotes cell proliferation. Mutations in TP53 are also found with high frequency (>50%) in sporadic BCC. More...
hsa04310	wnt signaling_pathway	Wnt signaling pathway	Wnt proteins are secreted morphogens that are required for b...... Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin. More...
hsa05200	pathways in_cancer	Pathways in cancer
hsa04916	melanogenesis	Melanogenesis	Cutaneous melanin pigment plays a critical role in camouflag...... Cutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory control by multiple agents. The most important positive regulator of melanogenesis is the MC1 receptor with its ligands melanocortic peptides. MC1R activates the cyclic AMP (cAMP) response-element binding protein (CREB). Increased expression of MITF and its activation by phosphorylation (P) stimulate the transcription of tyrosinase (TYR), tyrosinase-related protein 1 (TYRP1), and dopachrome tautomerase (DCT), which produce melanin. Melanin synthesis takes place within specialized intracellular organelles named melanosomes. Melanin-containing melanosomes then move from the perinuclear region to the dendrite tips and are transferred to keratinocytes by a still not well-characterized mechanism. More...

FZD9 related BioCarta pathways (count: 0)

FZD9 related Reactome pathways (count: 2)

ID	Name	Description
Gene mapped Reactome pathways
REACT_21340	gpcr ligand_binding	There are more than 800 G-protein coupled receptor. GPCRs ar...... There are more than 800 G-protein coupled receptor. GPCRs are receptors for a diverse range of ligands from large proteins to photons and have an equal diverstiy of ligand-binding mechanisms. Classical GPCR signaling involves signal transduction via heterotrimeric G-proteins, however many G-protein independent mechanisms have been reported. More...
REACT_18372	class b2_secretin_family_receptors	This family is known as Family B. This family is known as Family B.

FZD9 related interactors from protein-protein interaction data in HPRD (count: 4)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
FZD9	WNT2	No	in vivo	12138115
FZD9	WNT1	No	in vivo	9147651
FZD9	MDFI	No	yeast 2-hybrid	16189514
FZD9	WNT7A	No	in vivo	15705594

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped Reactome pathways