Gene Report

Basic Information

Approved Symbol	DTNBP1
Approved Name	dystrobrevin binding protein 1
Symbol Alias	Dysbindin, My031, HPS7, DBND, BLOC1S8
Name Alias	dysbindin-1, "biogenesis of lysosomal organelles complex-1, subunit 8"
Location	6p22.3
Position	chr6:15523032-15663289 (-)
External Links	Entrez Gene: 84062 Ensembl: ENSG00000047579 UCSC: uc003nbm.3 HGNC ID: 17328
No. of Studies (Positive/Negative)	2(1/1)
Type	Literature-origin

Positive relationships between DTNBP1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
DTNBP1	Kim, 2008	patients and normal controls	P-value=0.0007	Haplotype analyses revealed a significant association with M...... Haplotype analyses revealed a significant association with MDD (p=0.0007, protective A-C-T-A and A-C-C-C haplotypes), in particular the effect was due to the rs760761 (C/T) and rs2619522 (A/C) haplotype (p=0.000026). More...

Positive relationships between DTNBP1 and other components at different levels (count: 0)

Positive relationship network of DTNBP1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between DTNBP1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
DTNBP1	Zill P, 2004	Patients and nomal controls		Applying single SNP evaluation, as well as haplotype analysi...... Applying single SNP evaluation, as well as haplotype analysis we could not detect an association between the dysbindin polymorphisms and major depression or the response to antidepressant treatment. More...

Negative relationships between DTNBP1 and other components at different levels (count: 0)

DTNBP1 related SNPs in MK4MDD (count: 0)

DTNBP1 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Dysbindin	Q96EV8	0(0/0)	Gene mapped

DTNBP1 related GO terms (count: 33)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0030054	cell junction	cellular component	IEA
GO:0045211	postsynaptic membrane	cellular component	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005515	protein binding	molecular function	IPI
GO:0010008	endosome membrane	cellular component	IEA
GO:0030672	synaptic vesicle membrane	cellular component	IDA[16980328]; ISS
GO:0005737	cytoplasm	cellular component	ISS
GO:0033162	melanosome membrane	cellular component	IEA
GO:0001956	positive regulation of neurotransmitter secretion	biological process	ISS
GO:0031175	neuron projection development	biological process	IDA[16980328]
GO:0005789	endoplasmic reticulum membrane	cellular component	ISS
GO:0016044	cellular membrane organization	biological process	TAS
GO:0014059	regulation of dopamine secretion	biological process	ISS
GO:0005634	nucleus	cellular component	ISS
GO:0006892	post-Golgi vesicle-mediated transport	biological process	TAS
GO:0048812	neuron projection morphogenesis	biological process	ISS
GO:0060155	platelet dense granule organization	biological process	IEA
GO:0008089	anterograde axon cargo transport	biological process	ISS
GO:0005829	cytosol	cellular component	TAS
GO:0016528	sarcoplasm	cellular component	IEA
GO:0033267	axon part	cellular component	ISS
GO:0030426	growth cone	cellular component	ISS
GO:0031083	BLOC-1 complex	cellular component	IDA
GO:0060159	regulation of dopamine receptor signaling pathway	biological process	ISS
GO:0042383	sarcolemma	cellular component	ISS
GO:0030424	axon	cellular component	ISS
GO:0010628	positive regulation of gene expression	biological process	ISS
GO:0043005	neuron projection	cellular component	IDA[16980328]
GO:0014069	postsynaptic density	cellular component	IDA[16980328]
GO:0048490	anterograde synaptic vesicle transport	biological process	ISS
GO:0007596	blood coagulation	biological process	IEA
GO:0043197	dendritic spine	cellular component	ISS
GO:0032438	melanosome organization	biological process	NAS
GO:0031532	actin cytoskeleton reorganization	biological process	ISS

DTNBP1 related KEGG pathways (count: 0)

DTNBP1 related BioCarta pathways (count: 0)

DTNBP1 related Reactome pathways (count: 3)

ID	Name	Description
Gene mapped Reactome pathways
REACT_19400	golgi associated_vesicle_biogenesis	Proteins that have been synthesized, processed and sorted ev...... Proteins that have been synthesized, processed and sorted eventually reach the final steps of the secretory pathway. This pathway is responsible not only for proteins that are secreted from the cell but also enzymes and other resident proteins in the lumen of the ER, Golgi, and lysosomes as well as integral proteins transported in the vesicle membranes. More...
REACT_19187	clathrin derived_vesicle_budding	There at least two classes of clathrin coated vesicles in ce...... There at least two classes of clathrin coated vesicles in cells, one predominantly Golgi-associated, involved in budding from the trans-Golgi network and the other at the plasma membrane. Here the clathrin-coated vesicles emerging from the Golgi apparatus are triggered by the heterotetrameric adaptor protein complex, AP-1 at the trans-Golgi network membrane. The cargo can be transmembrane, membrane associated or golgi luminal proteins. Each step in the vesicle sculpting pathway, gathers cargo and clathrin triskeletons, until a complete vesicular sphere is formed. With the scission of the membrane the vesicle is released and eventually losses its clathrin coat. More...
REACT_11123	membrane trafficking	The secretory membrane system allows a cell to regulate deli...... The secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is made up of distinct organelles, including the endoplasmic reticulum (ER), Golgi complex, plasma membrane, and tubulovesicular transport intermediates. These organelles mediate intracellular membrane transport between themselves and the cell surface. Membrane traffic within this system flows along highly organized directional routes. Secretory cargo is synthesized and assembled in the ER and then transported to the Golgi complex for further processing and maturation. Upon arrival at the trans Golgi network (TGN), the cargo is sorted and packaged into post-Golgi carriers that move through the cytoplasm to fuse with the cell surface. This directional membrane flow is balanced by retrieval pathways that bring membrane and selected proteins back to the compartment of origin. More...

DTNBP1 related interactors from protein-protein interaction data in HPRD (count: 10)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
DTNBP1	DGCR6L	No	yeast 2-hybrid	16189514
DTNBP1	MUTED	No	in vivo;yeast 2-hybrid	15102850
DTNBP1	DTNA	No	in vivo	11316798
DTNBP1	ABI3	No	yeast 2-hybrid	16189514
DTNBP1	SNAPIN	No	yeast 2-hybrid	15102850
DTNBP1	PLDN	No	yeast 2-hybrid	15102850
DTNBP1	CMYA5	No	in vitro;in vivo;yeast 2-hybrid	14688250
DTNBP1	DTNB	No	in vitro;in vivo;yeast 2-hybrid	11316798
DTNBP1	ARFIP2	No	yeast 2-hybrid	16189514
DTNBP1	CCND3	No	yeast 2-hybrid	16189514

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped Reactome pathways