Gene Report

Basic Information

Approved Symbol	NPAS3
Approved Name	neuronal PAS domain protein 3
Symbol Alias	MOP6, PASD6, bHLHe12
Location	14q12-q13
Position	chr14:33408459-34273382 (+)
External Links	Entrez Gene: 64067 Ensembl: ENSG00000151322 UCSC: uc001wru.3 HGNC ID: 19311
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between NPAS3 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
NPAS3	Huang, 2011	patients and normal controls		Findings revealed evidence suggesting that several genes may...... Findings revealed evidence suggesting that several genes may have effects that transcend clinical diagnostic boundaries, including variants in NPAS3 that showed pleiotropic effects across schizophrenia, bipolar disorder, and major depressive disorder. More...

Positive relationships between NPAS3 and other components at different levels (count: 0)

Positive relationship network of NPAS3 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between NPAS3 and MDD (count: 0)

Negative relationships between NPAS3 and other components at different levels (count: 0)

NPAS3 related SNPs in MK4MDD (count: 0)

NPAS3 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Neuronal PAS domain-containing protein 3	Q8IXF0	0(0/0)	Gene mapped

NPAS3 related GO terms (count: 11)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0045893	positive regulation of transcription, DNA-dependent	biological process	ISS
GO:0004871	signal transducer activity	molecular function	IEA
GO:0005634	nucleus	cellular component	IDA
GO:0007626	locomotory behavior	biological process	IEA
GO:0006351	transcription, DNA-dependent	biological process	IEA
GO:0003677	DNA binding	molecular function	IEA
GO:0005737	cytoplasm	cellular component	IDA
GO:0035176	social behavior	biological process	IEA
GO:0005730	nucleolus	cellular component	IDA
GO:0046983	protein dimerization activity	molecular function	IEA
GO:0042711	maternal behavior	biological process	IEA

NPAS3 related KEGG pathways (count: 0)

NPAS3 related BioCarta pathways (count: 0)

NPAS3 related Reactome pathways (count: 0)

NPAS3 related interactors from protein-protein interaction data in HPRD (count: 0)

Gene Report

Gene mapped GO terms