Gene Report

Basic Information

Approved Symbol	GPR50
Approved Name	G protein-coupled receptor 50
Symbol Alias	H9, Mel1c
Location	Xq28
Position	chrX:150349910-150349937 (+)
External Links	Entrez Gene: 9248 Ensembl: ENSG00000102195 UCSC: uc010ntg.2 HGNC ID: 4506
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between GPR50 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
GPR50	Thomson, 2005	patients and normal controls	P-value<0.05	Significant associations were found between an insertion/del...... Significant associations were found between an insertion/deletion polymorphism in exon 2 and both BPAD (P=0.0070), and MDD (P=0.011) with increased risk associated with the deletion variant (GPR50(Delta502-505)) More...

Positive relationships between GPR50 and other components at different levels (count: 0)

Positive relationship network of GPR50 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between GPR50 and MDD (count: 0)

Negative relationships between GPR50 and other components at different levels (count: 0)

GPR50 related SNPs in MK4MDD (count: 0)

GPR50 related proteins in MK4MDD (count: 0)

GPR50 related GO terms (count: 8)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0042802	identical protein binding	molecular function	IPI[16778767]
GO:0005887	integral component of plasma membrane	cellular component	TAS[8647286]
GO:0007267	cell-cell signaling	biological process	TAS[8647286]
GO:0005515	protein binding	molecular function	IPI[16778767\|25416956]
GO:0007166	cell surface receptor signaling pathway	biological process	IBA
GO:0004930	G-protein coupled receptor activity	molecular function	TAS[8647286]
GO:0007186	G-protein coupled receptor signaling pathway	biological process	IEA
GO:0008502	melatonin receptor activity	molecular function	IEA

GPR50 related KEGG pathways (count: 1)

Gene mapped KEGG pathways
ID	Name	Brief Description	Full Description
hsa04080	neuroactive ligand_receptor_interaction	Neuroactive ligand-receptor interaction

GPR50 related BioCarta pathways (count: 0)

GPR50 related Reactome pathways (count: 0)

GPR50 related interactors from protein-protein interaction data in HPRD (count: 3)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
GPR50	MTNR1B	No	in vitro;in vivo	16778767
GPR50	MTNR1A	No	in vitro;in vivo	16778767
GPR50	GPR50	Yes	in vivo	16778767

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways