
Gene Report
Approved Symbol | PTN |
---|---|
Approved Name | pleiotrophin |
Previous Symbol | NEGF1 |
Previous Name | neurite growth-promoting factor 1 |
Symbol Alias | HBNF, HBGF8 |
Name Alias | heparin binding growth factor 8 |
Location | 7q33 |
Position | chr7:136912088-137028546 (-) |
External Links |
Entrez Gene: 5764 Ensembl: ENSG00000105894 UCSC: uc003vtq.2 HGNC ID: 9630 |
No. of Studies (Positive/Negative) | 1(1/0)
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Type | Literature-origin |
Name in Literature | Reference | Research Type | Statistical Result | Relation Description | ![]() |
---|---|---|---|---|---|
Pleiotrophin | Tochigi, 2008 | patients and normal controls | Genes differentially expressed in major depression Genes differentially expressed in major depression |
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus | Protein and Other Molecule | Cell and Molecular Pathway | Neural System | Cognition and Behavior | Symptoms and Signs | Environment | MDD |
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2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Approved Name | UniportKB | No. of Studies (Positive/Negative) | Source | |
---|---|---|---|---|
Pleiotrophin | P21246 | 0(0/0) | Gene mapped |
Gene mapped GO terms | ||||
ID | Name | Type | Evidence | |
---|---|---|---|---|
GO:0004864 | protein phosphatase inhibitor activity | molecular function | TAS[10706604] | |
GO:0007399 | nervous system development | biological process | TAS[2270483] | |
GO:0030282 | bone mineralization | biological process | IEA | |
GO:0007185 | transmembrane receptor protein tyrosine phosphatase signaling pathway | biological process | TAS[10706604] | |
GO:0005783 | endoplasmic reticulum | cellular component | IDA | |
GO:0008201 | heparin binding | molecular function | IEA | |
GO:0051781 | positive regulation of cell division | biological process | IEA | |
GO:0005615 | extracellular space | cellular component | TAS[10706604] | |
GO:0007612 | learning | biological process | IEA | |
GO:0008083 | growth factor activity | molecular function | IEA | |
GO:0008284 | positive regulation of cell proliferation | biological process | TAS[2270483] |

Gene | Interactor | Interactor in MK4MDD? | Experiment Type | PMID | |
---|---|---|---|---|---|
PTN | CAPZB | No | yeast 2-hybrid | 16169070 | |
PTN | DNAJB11 | No | yeast 2-hybrid | 16169070 | |
PTN | GLYAT | No | yeast 2-hybrid | 16169070 | |
PTN | PPP2CA | No | yeast 2-hybrid | 16169070 | |
PTN | PSMD2 | No | yeast 2-hybrid | 16169070 | |
PTN | PSMD11 | Yes | yeast 2-hybrid | 16169070 | |
PTN | PTPRS | No | yeast 2-hybrid | 16169070 | |
PTN | GSTP1 | No | yeast 2-hybrid | 16169070 | |
PTN | RBM23 | No | yeast 2-hybrid | 16169070 | |
PTN | PLXNB2 | No | yeast 2-hybrid | 16169070 | |
PTN | BTBD2 | No | yeast 2-hybrid | 16169070 | |
PTN | BMI1 | No | yeast 2-hybrid | 16169070 | |
PTN | TP53BP2 | No | yeast 2-hybrid | 16169070 | |
PTN | MKKS | No | yeast 2-hybrid | 16169070 | |
PTN | CHD3 | No | yeast 2-hybrid | 15383276 | |
PTN | DFNA5 | No | yeast 2-hybrid | 16169070 | |
PTN | APOBEC3G | No | yeast 2-hybrid | 16169070 | |
PTN | PMF1 | No | yeast 2-hybrid | 16169070 | |
PTN | PTN | Yes | in vitro;yeast 2-hybrid | 10600521 , 15383276 | |
PTN | HSPBAP1 | No | yeast 2-hybrid | 16169070 | |
PTN | CRELD1 | No | yeast 2-hybrid | 16169070 | |
PTN | CCDC53 | No | yeast 2-hybrid | 16169070 | |
PTN | CACNB4 | No | yeast 2-hybrid | 16169070 | |
PTN | FEZ1 | No | yeast 2-hybrid | 15383276 | |
PTN | GNB2L1 | No | yeast 2-hybrid | 16169070 | |
PTN | GIPC2 | No | yeast 2-hybrid | 16169070 | |
PTN | CSTA | No | yeast 2-hybrid | 16169070 | |
PTN | PSMB10 | No | yeast 2-hybrid | 16169070 | |
PTN | TAF1D | No | yeast 2-hybrid | 16169070 | |
PTN | ACTB | No | in vivo | 9739080 | |
PTN | SGSM2 | No | yeast 2-hybrid | 16169070 | |
PTN | TBRG4 | No | yeast 2-hybrid | 16169070 | |
PTN | BCCIP | No | yeast 2-hybrid | 16169070 | |
PTN | STC2 | No | yeast 2-hybrid | 16169070 | |
PTN | SUPT7L | No | yeast 2-hybrid | 16169070 | |
PTN | MLLT3 | No | yeast 2-hybrid | 16169070 | |
PTN | TAC3 | No | yeast 2-hybrid | 16169070 | |
PTN | ARL15 | No | yeast 2-hybrid | 16169070 | |
PTN | UTP3 | No | yeast 2-hybrid | 16169070 | |
PTN | SGTA | No | yeast 2-hybrid | 16169070 | |
PTN | FAM176A | No | yeast 2-hybrid | 16169070 | |
PTN | UBQLN4 | No | yeast 2-hybrid | 16169070 , 16713569 | |
PTN | ATRX | No | yeast 2-hybrid | 16169070 | |
PTN | SAT1 | Yes | yeast 2-hybrid | 16169070 | |
PTN | GTF2F1 | No | yeast 2-hybrid | 16169070 | |
PTN | BARD1 | No | yeast 2-hybrid | 15383276 | |
PTN | LAMA4 | No | yeast 2-hybrid | 16169070 | |
PTN | TOMM20 | No | yeast 2-hybrid | 16169070 | |
PTN | C8orf30A | No | yeast 2-hybrid | 16169070 | |
PTN | KPNB1 | No | yeast 2-hybrid | 15383276 | |
PTN | LUC7L2 | No | yeast 2-hybrid | 16169070 | |
PTN | C9orf82 | No | yeast 2-hybrid | 16169070 | |
PTN | SSR1 | Yes | yeast 2-hybrid | 16169070 | |
PTN | MYCBP | No | yeast 2-hybrid | 16169070 | |
PTN | RPLP1 | No | yeast 2-hybrid | 16169070 | |
PTN | FTL | No | yeast 2-hybrid | 16169070 | |
PTN | DUSP12 | No | yeast 2-hybrid | 16169070 | |
PTN | CDH10 | No | yeast 2-hybrid | 16169070 | |
PTN | SDC3 | No | in vitro | 8175719 | |
PTN | PTPRZ1 | Yes | in vitro;in vivo | 10706604 , 16814777 | |
PTN | RIT1 | No | yeast 2-hybrid | 16169070 | |
PTN | PIAS4 | No | yeast 2-hybrid | 15383276 | |
PTN | SDC1 | No | in vitro | 7592855 | |
PTN | SPIN1 | No | yeast 2-hybrid | 16169070 | |
PTN | COX6C | No | yeast 2-hybrid | 16169070 | |
PTN | CDK5RAP2 | No | yeast 2-hybrid | 16169070 | |
PTN | TXNDC9 | No | yeast 2-hybrid | 16169070 | |
PTN | WFDC2 | No | yeast 2-hybrid | 16169070 | |
PTN | NAP1L5 | No | yeast 2-hybrid | 16169070 | |
PTN | P4HB | No | yeast 2-hybrid | 16169070 | |
PTN | ATP5C1 | No | yeast 2-hybrid | 16169070 | |
PTN | SNCAIP | No | yeast 2-hybrid | 16169070 | |
PTN | NCAN | No | in vitro | 9507007 | |
PTN | ITSN2 | No | yeast 2-hybrid | 16169070 | |
PTN | GADD45G | No | yeast 2-hybrid | 15383276 | |
PTN | ARIH2 | No | yeast 2-hybrid | 16169070 | |
PTN | CRCT1 | No | yeast 2-hybrid | 16169070 | |
PTN | SLC25A36 | No | yeast 2-hybrid | 16169070 | |
PTN | BLOC1S1 | No | yeast 2-hybrid | 16169070 | |
PTN | ALK | No | in vitro;in vivo | 11278720 | |
PTN | GPD1 | No | yeast 2-hybrid | 16169070 | |
PTN | CGA | No | yeast 2-hybrid | 16169070 | |
PTN | EIF3F | No | yeast 2-hybrid | 16169070 | |
PTN | MAD2L1BP | No | yeast 2-hybrid | 16169070 |