Gene Report

Basic Information

Approved Symbol	PTN
Approved Name	pleiotrophin
Previous Symbol	NEGF1
Previous Name	"neurite growth-promoting factor 1"
Symbol Alias	HBNF, HBGF8
Name Alias	"heparin binding growth factor 8"
Location	7q33
Position	chr7:137028185-137028546 (-)
External Links	Entrez Gene: 5764 Ensembl: ENSG00000105894 UCSC: uc003vtq.2 HGNC ID: 9630
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between PTN and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
Pleiotrophin	Tochigi, 2008	patients and normal controls		Genes differentially expressed in major depression Genes differentially expressed in major depression

Positive relationships between PTN and other components at different levels (count: 0)

Positive relationship network of PTN in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between PTN and MDD (count: 0)

Negative relationships between PTN and other components at different levels (count: 0)

PTN related SNPs in MK4MDD (count: 0)

PTN related proteins in MK4MDD (count: 0)

PTN related GO terms (count: 55)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0004864	protein phosphatase inhibitor activity	molecular function	TAS[10706604]
GO:1990089	response to nerve growth factor	biological process	IEA
GO:0021794	thalamus development	biological process	IEA
GO:0014823	response to activity	biological process	IEA
GO:0031594	neuromuscular junction	cellular component	IEA
GO:0001889	liver development	biological process	IEA
GO:0032570	response to progesterone	biological process	IEA
GO:0030336	negative regulation of cell migration	biological process	IEA
GO:1904391	response to ciliary neurotrophic factor	biological process	IEA
GO:0008201	heparin binding	molecular function	IEA
GO:0048471	perinuclear region of cytoplasm	cellular component	IEA
GO:0016020	membrane	cellular component	IEA
GO:0008360	regulation of cell shape	biological process	IEA
GO:0009986	cell surface	cellular component	IEA
GO:0045837	negative regulation of membrane potential	biological process	IEA
GO:1904397	negative regulation of neuromuscular junction development	biological process	IEA
GO:2000347	positive regulation of hepatocyte proliferation	biological process	IEA
GO:1904373	response to kainic acid	biological process	IEA
GO:0007399	nervous system development	biological process	TAS[2270483]
GO:0007612	learning	biological process	IEA
GO:0007507	heart development	biological process	IEA
GO:0030324	lung development	biological process	IEA
GO:0010976	positive regulation of neuron projection development	biological process	IEA
GO:0071456	cellular response to hypoxia	biological process	IEA
GO:0032355	response to estradiol	biological process	IEA
GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway	biological process	TAS[10706604]
GO:0021549	cerebellum development	biological process	IEA
GO:0044849	estrous cycle	biological process	IEA
GO:0021510	spinal cord development	biological process	IEA
GO:0008083	growth factor activity	molecular function	IEA
GO:0005615	extracellular space	cellular component	TAS[10706604]
GO:1904399	heparan sulfate binding	molecular function	IEA
GO:0035373	chondroitin sulfate proteoglycan binding	molecular function	IEA
GO:0034644	cellular response to UV	biological process	IEA
GO:0060221	retinal rod cell differentiation	biological process	IEA
GO:0010811	positive regulation of cell-substrate adhesion	biological process	IEA
GO:0016525	negative regulation of angiogenesis	biological process	IEA
GO:0008284	positive regulation of cell proliferation	biological process	TAS[2270483]
GO:0071305	cellular response to vitamin D	biological process	IEA
GO:0042493	response to drug	biological process	IEA
GO:0030282	bone mineralization	biological process	IEA
GO:0043065	positive regulation of apoptotic process	biological process	IEA
GO:0005604	basement membrane	cellular component	IEA
GO:0038085	vascular endothelial growth factor binding	molecular function	IEA
GO:0043086	negative regulation of catalytic activity	biological process	TAS[10706604]
GO:1904389	rod bipolar cell differentiation	biological process	IEA
GO:0060253	negative regulation of glial cell proliferation	biological process	IEA
GO:0051781	positive regulation of cell division	biological process	IEA
GO:0060291	long-term synaptic potentiation	biological process	IEA
GO:0005783	endoplasmic reticulum	cellular component	IDA
GO:0045446	endothelial cell differentiation	biological process	IEA
GO:1904395	positive regulation of skeletal muscle acetylcholine-gated channel clustering	biological process	IEA
GO:0072201	negative regulation of mesenchymal cell proliferation	biological process	IEA
GO:0036120	cellular response to platelet-derived growth factor stimulus	biological process	IEA
GO:0050680	negative regulation of epithelial cell proliferation	biological process	IEA

PTN related KEGG pathways (count: 0)

PTN related BioCarta pathways (count: 0)

PTN related Reactome pathways (count: 0)

PTN related interactors from protein-protein interaction data in HPRD (count: 84)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
PTN	GNB2L1	No	yeast 2-hybrid	16169070
PTN	GSTP1	No	yeast 2-hybrid	16169070
PTN	CRELD1	No	yeast 2-hybrid	16169070
PTN	EIF3F	No	yeast 2-hybrid	16169070
PTN	RBM23	No	yeast 2-hybrid	16169070
PTN	MAD2L1BP	No	yeast 2-hybrid	16169070
PTN	FEZ1	No	yeast 2-hybrid	15383276
PTN	C9orf82	No	yeast 2-hybrid	16169070
PTN	TBRG4	No	yeast 2-hybrid	16169070
PTN	CRCT1	No	yeast 2-hybrid	16169070
PTN	ARIH2	No	yeast 2-hybrid	16169070
PTN	UBQLN4	No	yeast 2-hybrid	16169070 , 16713569
PTN	DUSP12	No	yeast 2-hybrid	16169070
PTN	SAT1	Yes	yeast 2-hybrid	16169070
PTN	SSR1	Yes	yeast 2-hybrid	16169070
PTN	SGSM2	No	yeast 2-hybrid	16169070
PTN	CHD3	No	yeast 2-hybrid	15383276
PTN	PIAS4	No	yeast 2-hybrid	15383276
PTN	PTPRZ1	Yes	in vitro;in vivo	10706604 , 16814777
PTN	ATRX	No	yeast 2-hybrid	16169070
PTN	GPD1	No	yeast 2-hybrid	16169070
PTN	COX6C	No	yeast 2-hybrid	16169070
PTN	CDH10	No	yeast 2-hybrid	16169070
PTN	PLXNB2	No	yeast 2-hybrid	16169070
PTN	CAPZB	No	yeast 2-hybrid	16169070
PTN	NCAN	Yes	in vitro	9507007
PTN	BLOC1S1	No	yeast 2-hybrid	16169070
PTN	LAMA4	No	yeast 2-hybrid	16169070
PTN	C8orf30A	No	yeast 2-hybrid	16169070
PTN	GLYAT	No	yeast 2-hybrid	16169070
PTN	ACTB	No	in vivo	9739080
PTN	PSMB10	No	yeast 2-hybrid	16169070
PTN	SNCAIP	No	yeast 2-hybrid	16169070
PTN	PTPRS	No	yeast 2-hybrid	16169070
PTN	CGA	No	yeast 2-hybrid	16169070
PTN	CSTA	No	yeast 2-hybrid	16169070
PTN	ALK	No	in vitro;in vivo	11278720
PTN	GIPC2	No	yeast 2-hybrid	16169070
PTN	PTN	Yes	in vitro;yeast 2-hybrid	10600521 , 15383276
PTN	SDC1	No	in vitro	7592855
PTN	KPNB1	No	yeast 2-hybrid	15383276
PTN	HSPBAP1	No	yeast 2-hybrid	16169070
PTN	TOMM20	No	yeast 2-hybrid	16169070
PTN	LUC7L2	No	yeast 2-hybrid	16169070
PTN	SUPT7L	No	yeast 2-hybrid	16169070
PTN	CACNB4	No	yeast 2-hybrid	16169070
PTN	MKKS	No	yeast 2-hybrid	16169070
PTN	UTP3	No	yeast 2-hybrid	16169070
PTN	RIT1	No	yeast 2-hybrid	16169070
PTN	WFDC2	No	yeast 2-hybrid	16169070
PTN	PMF1	No	yeast 2-hybrid	16169070
PTN	DFNA5	No	yeast 2-hybrid	16169070
PTN	SPIN1	No	yeast 2-hybrid	16169070
PTN	APOBEC3G	Yes	yeast 2-hybrid	16169070
PTN	BCCIP	No	yeast 2-hybrid	16169070
PTN	PSMD11	Yes	yeast 2-hybrid	16169070
PTN	TP53BP2	No	yeast 2-hybrid	16169070
PTN	SLC25A36	No	yeast 2-hybrid	16169070
PTN	ATP5C1	No	yeast 2-hybrid	16169070
PTN	P4HB	No	yeast 2-hybrid	16169070
PTN	FTL	No	yeast 2-hybrid	16169070
PTN	CCDC53	No	yeast 2-hybrid	16169070
PTN	GTF2F1	No	yeast 2-hybrid	16169070
PTN	BTBD2	No	yeast 2-hybrid	16169070
PTN	CDK5RAP2	No	yeast 2-hybrid	16169070
PTN	MYCBP	No	yeast 2-hybrid	16169070
PTN	SGTA	No	yeast 2-hybrid	16169070
PTN	NAP1L5	No	yeast 2-hybrid	16169070
PTN	GADD45G	No	yeast 2-hybrid	15383276
PTN	STC2	No	yeast 2-hybrid	16169070
PTN	ARL15	No	yeast 2-hybrid	16169070
PTN	TXNDC9	No	yeast 2-hybrid	16169070
PTN	TAF1D	No	yeast 2-hybrid	16169070
PTN	MLLT3	No	yeast 2-hybrid	16169070
PTN	PPP2CA	No	yeast 2-hybrid	16169070
PTN	BARD1	No	yeast 2-hybrid	15383276
PTN	FAM176A	No	yeast 2-hybrid	16169070
PTN	DNAJB11	No	yeast 2-hybrid	16169070
PTN	PSMD2	No	yeast 2-hybrid	16169070
PTN	SDC3	No	in vitro	8175719
PTN	TAC3	No	yeast 2-hybrid	16169070
PTN	BMI1	No	yeast 2-hybrid	16169070
PTN	ITSN2	No	yeast 2-hybrid	16169070
PTN	RPLP1	No	yeast 2-hybrid	16169070

Gene Report

Gene mapped GO terms