Gene Report

Basic Information

Approved Symbol	NUPR1
Approved Name	nuclear protein, transcriptional regulator, 1
Symbol Alias	COM1, p8
Name Alias	candidate of metastasis 1
Location	16p11.2
Position	chr16:28548662-28550495 (-)
External Links	Entrez Gene: 26471 Ensembl: ENSG00000176046 UCSC: uc002dqd.1 HGNC ID: 29990
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between NUPR1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
P8 protein	Tochigi, 2008	patients and normal controls		Genes differentially expressed in major depression Genes differentially expressed in major depression

Positive relationships between NUPR1 and other components at different levels (count: 0)

Positive relationship network of NUPR1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between NUPR1 and MDD (count: 0)

Negative relationships between NUPR1 and other components at different levels (count: 0)

NUPR1 related SNPs in MK4MDD (count: 0)

NUPR1 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Nuclear protein 1	O60356	0(0/0)	Gene mapped

NUPR1 related GO terms (count: 19)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0006461	protein complex assembly	biological process	IEA
GO:0003682	chromatin binding	molecular function	IEA
GO:0035914	skeletal muscle cell differentiation	biological process	IEA
GO:2000194	regulation of female gonad development	biological process	IEA
GO:0003677	DNA binding	molecular function	IEA
GO:0016049	cell growth	biological process	IDA[10092851]
GO:0002526	acute inflammatory response	biological process	IEA
GO:0045786	negative regulation of cell cycle	biological process	IEA
GO:0006473	protein acetylation	biological process	IEA
GO:0006917	induction of apoptosis	biological process	NAS
GO:0031401	positive regulation of protein modification process	biological process	IEA
GO:0006355	regulation of transcription, DNA-dependent	biological process	IEA
GO:0003674	molecular_function	molecular function	ND
GO:0048147	negative regulation of fibroblast proliferation	biological process	IEA
GO:0009636	response to toxin	biological process	IEA
GO:0005634	nucleus	cellular component	IDA[10092851]
GO:0008584	male gonad development	biological process	IEA
GO:0006351	transcription, DNA-dependent	biological process	IEA
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	biological process	IEA

NUPR1 related KEGG pathways (count: 0)

NUPR1 related BioCarta pathways (count: 0)

NUPR1 related Reactome pathways (count: 0)

NUPR1 related interactors from protein-protein interaction data in HPRD (count: 2)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
NUPR1	EP300	Yes	in vitro	11940591
NUPR1	PAXIP1	No	in vitro;yeast 2-hybrid	11940591

Gene Report

Gene mapped GO terms