
Gene Report
Approved Symbol | SIRT1 |
---|---|
Approved Name | sirtuin 1 |
Previous Name | sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 1, "sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)" |
Symbol Alias | SIR2L1 |
Location | 10q21 |
Position | chr10:69644427-69678147 (+) |
External Links |
Entrez Gene: 23411 Ensembl: ENSG00000096717 UCSC: uc001jnd.3 HGNC ID: 14929 |
No. of Studies (Positive/Negative) | 1(1/0)
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Type | Literature-origin; SNP mapped |
Name in Literature | Reference | Research Type | Statistical Result | Relation Description | ![]() |
---|---|---|---|---|---|
SIRT1 | Kishi, 2010 | patients and normal controls | We found an association between rs10997875 in SIRT1 gene and...... We found an association between rs10997875 in SIRT1 gene and MDD in the allele/genotype analysis. More... |
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus | Protein and Other Molecule | Cell and Molecular Pathway | Neural System | Cognition and Behavior | Symptoms and Signs | Environment | MDD |
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2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

#rs | Location | Annotation | No. of Studies (Positive/Negative) | |
---|---|---|---|---|
rs10997875 | chr10:69679824(Forward) | downstream_gene_variant | 1(1/0) |
Approved Name | UniportKB | No. of Studies (Positive/Negative) | Source | |
---|---|---|---|---|
NAD-dependent protein deacetylase sirtuin-1 | Q96EB6 | 0(0/0) | Gene mapped |
Gene mapped GO terms | ||||
ID | Name | Type | Evidence | |
---|---|---|---|---|
GO:0042393 | histone binding | molecular function | IPI[15469825] | |
GO:0001934 | positive regulation of protein phosphorylation | biological process | ISS | |
GO:0007517 | muscle organ development | biological process | IEA | |
GO:0007346 | regulation of mitotic cell cycle | biological process | IDA[15692560] | |
GO:0042981 | regulation of apoptotic process | biological process | ISS[11672522] | |
GO:0004407 | histone deacetylase activity | molecular function | IDA | |
GO:0043398 | HLH domain binding | molecular function | IPI[12535671] | |
GO:0031648 | protein destabilization | biological process | ISS | |
GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway | biological process | ISS | |
GO:2000773 | negative regulation of cellular senescence | biological process | IDA | |
GO:0005677 | chromatin silencing complex | cellular component | IDA[18485871] | |
GO:0035358 | regulation of peroxisome proliferator activated receptor signaling pathway | biological process | ISS | |
GO:0055089 | fatty acid homeostasis | biological process | ISS | |
GO:0046628 | positive regulation of insulin receptor signaling pathway | biological process | IDA | |
GO:0005719 | nuclear euchromatin | cellular component | IDA[15469825] | |
GO:0070857 | regulation of bile acid biosynthetic process | biological process | ISS | |
GO:0007283 | spermatogenesis | biological process | IEA | |
GO:0042632 | cholesterol homeostasis | biological process | ISS | |
GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator | biological process | IDA[11672523] | |
GO:0031937 | positive regulation of chromatin silencing | biological process | IMP[15469825] | |
GO:0006974 | response to DNA damage stimulus | biological process | IDA[18203716] | |
GO:0000183 | chromatin silencing at rDNA | biological process | IDA[18485871] | |
GO:0006979 | response to oxidative stress | biological process | IDA[14976264] | |
GO:0050872 | white fat cell differentiation | biological process | ISS | |
GO:0000790 | nuclear chromatin | cellular component | IDA[17505061] | |
GO:0006343 | establishment of chromatin silencing | biological process | IDA[15469825] | |
GO:2000480 | negative regulation of cAMP-dependent protein kinase activity | biological process | IDA | |
GO:0006342 | chromatin silencing | biological process | TAS[10381378] | |
GO:0010875 | positive regulation of cholesterol efflux | biological process | ISS | |
GO:2000111 | positive regulation of macrophage apoptotic process | biological process | ISS | |
GO:0051019 | mitogen-activated protein kinase binding | molecular function | IPI | |
GO:0042127 | regulation of cell proliferation | biological process | IMP[12006491] | |
GO:0008284 | positive regulation of cell proliferation | biological process | IMP | |
GO:0006642 | triglyceride mobilization | biological process | ISS | |
GO:0032868 | response to insulin stimulus | biological process | ISS | |
GO:0070403 | NAD+ binding | molecular function | IEA | |
GO:0033158 | regulation of protein import into nucleus, translocation | biological process | IMP[18203716] | |
GO:0071479 | cellular response to ionizing radiation | biological process | ISS | |
GO:0003714 | transcription corepressor activity | molecular function | IDA[12535671]; ISS | |
GO:0080134 | regulation of response to stress | biological process | IDA[19934257] | |
GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | biological process | IDA | |
GO:0045599 | negative regulation of fat cell differentiation | biological process | ISS | |
GO:0016605 | PML body | cellular component | IDA[12006491] | |
GO:0071356 | cellular response to tumor necrosis factor | biological process | IDA[15152190] | |
GO:0051097 | negative regulation of helicase activity | biological process | IDA[18203716] | |
GO:0000012 | single strand break repair | biological process | IMP | |
GO:0070301 | cellular response to hydrogen peroxide | biological process | IDA | |
GO:0033558 | protein deacetylase activity | molecular function | IDA | |
GO:0008022 | protein C-terminus binding | molecular function | IPI[18203716] | |
GO:0006260 | DNA replication | biological process | TAS[17317627] | |
GO:0016567 | protein ubiquitination | biological process | IDA | |
GO:0045348 | positive regulation of MHC class II biosynthetic process | biological process | IDA | |
GO:2000655 | negative regulation of cellular response to testosterone stimulus | biological process | IMP[17505061] | |
GO:0031393 | negative regulation of prostaglandin biosynthetic process | biological process | ISS | |
GO:0001678 | cellular glucose homeostasis | biological process | ISS | |
GO:0042326 | negative regulation of phosphorylation | biological process | IMP[17612497] | |
GO:0005737 | cytoplasm | cellular component | IDA; IDA[15469825] | |
GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | biological process | IDA[12535671]; IMP | |
GO:0000731 | DNA synthesis involved in DNA repair | biological process | ISS | |
GO:0034979 | NAD-dependent protein deacetylase activity | molecular function | IDA; IMP[11672523] | |
GO:0005635 | nuclear envelope | cellular component | IDA[15469825] | |
GO:0034983 | peptidyl-lysine deacetylation | biological process | IDA[15469825] | |
GO:0045739 | positive regulation of DNA repair | biological process | IMP[19934257] | |
GO:0001525 | angiogenesis | biological process | IDA | |
GO:0016239 | positive regulation of macroautophagy | biological process | IDA[18296641] | |
GO:0005654 | nucleoplasm | cellular component | IDA[16079181] | |
GO:0046872 | metal ion binding | molecular function | IEA | |
GO:0002039 | p53 binding | molecular function | IPI[11672523] | |
GO:0043065 | positive regulation of apoptotic process | biological process | IDA[15152190]; IMP[19047049] | |
GO:0006351 | transcription, DNA-dependent | biological process | IEA | |
GO:0045892 | negative regulation of transcription, DNA-dependent | biological process | IDA[11672523] | |
GO:2000481 | positive regulation of cAMP-dependent protein kinase activity | biological process | IMP[18687677] | |
GO:0043161 | proteasomal ubiquitin-dependent protein catabolic process | biological process | IMP | |
GO:0006346 | methylation-dependent chromatin silencing | biological process | TAS | |
GO:0035098 | ESC/E(Z) complex | cellular component | IDA[15684044] | |
GO:0019213 | deacetylase activity | molecular function | IDA[18203716] | |
GO:0001542 | ovulation from ovarian follicle | biological process | IEA | |
GO:0017136 | NAD-dependent histone deacetylase activity | molecular function | IDA[12006491] | |
GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB cascade | biological process | IDA[17680780] | |
GO:0032007 | negative regulation of TOR signaling cascade | biological process | IMP | |
GO:0003950 | NAD+ ADP-ribosyltransferase activity | molecular function | TAS[17456799] | |
GO:0046969 | NAD-dependent histone deacetylase activity (H3-K9 specific) | molecular function | ISS | |
GO:2000774 | positive regulation of cellular senescence | biological process | IDA[18687677] | |
GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | biological process | IMP[19047049] | |
GO:0006344 | maintenance of chromatin silencing | biological process | IMP[15469825] | |
GO:0034391 | regulation of smooth muscle cell apoptotic process | biological process | ISS | |
GO:0033553 | rDNA heterochromatin | cellular component | IDA[18485871] | |
GO:0005637 | nuclear inner membrane | cellular component | IDA[15469825] | |
GO:0010906 | regulation of glucose metabolic process | biological process | ISS | |
GO:0005634 | nucleus | cellular component | IDA | |
GO:0005515 | protein binding | molecular function | IPI[12006491] | |
GO:0051898 | negative regulation of protein kinase B signaling cascade | biological process | IMP | |
GO:0000720 | pyrimidine dimer repair by nucleotide-excision repair | biological process | IMP | |
GO:0071456 | cellular response to hypoxia | biological process | IMP | |
GO:0060766 | negative regulation of androgen receptor signaling pathway | biological process | IMP[17505061] | |
GO:0007569 | cell aging | biological process | TAS[11672523] | |
GO:0006471 | protein ADP-ribosylation | biological process | TAS[17456799] | |
GO:0006281 | DNA repair | biological process | TAS[17317627] | |
GO:0030308 | negative regulation of cell growth | biological process | IMP[17505061] | |
GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | biological process | IMP | |
GO:0009267 | cellular response to starvation | biological process | ISS | |
GO:0018394 | peptidyl-lysine acetylation | biological process | IMP[18004385] | |
GO:0042802 | identical protein binding | molecular function | IPI[15469825] | |
GO:0032071 | regulation of endodeoxyribonuclease activity | biological process | IMP[19934257] | |
GO:0032088 | negative regulation of NF-kappaB transcription factor activity | biological process | IDA[15152190] | |
GO:0002821 | positive regulation of adaptive immune response | biological process | IDA | |
GO:0006364 | rRNA processing | biological process | IEA | |
GO:0035356 | cellular triglyceride homeostasis | biological process | ISS | |
GO:0043066 | negative regulation of apoptotic process | biological process | IMP; TAS[17317627] | |
GO:0043433 | negative regulation of sequence-specific DNA binding transcription factor activity | biological process | IDA[11672523]; IMP[17505061] | |
GO:0005720 | nuclear heterochromatin | cellular component | IDA[15469825] | |
GO:0019048 | virus-host interaction | biological process | IEA | |
GO:0070932 | histone H3 deacetylation | biological process | IDA; IMP[17505061] | |
GO:0016575 | histone deacetylation | biological process | IDA[12006491] | |
GO:0006476 | protein deacetylation | biological process | IDA; IMP[11672523] | |
GO:0005730 | nucleolus | cellular component | IDA[15469825]; IDA[16079181] | |
GO:0043425 | bHLH transcription factor binding | molecular function | IPI[12535671] | |
GO:2000757 | negative regulation of peptidyl-lysine acetylation | biological process | IDA |
Gene mapped BioCarta pathways | ||||
ID | Name | Brief Description | Full Description | |
---|---|---|---|---|
PML_PATHWAY | pml pathway | Regulation of transcriptional activity by PML | The PML nuclear bodies are ring-shaped nuclear substructures...... The PML nuclear bodies are ring-shaped nuclear substructures associated with the regulation of transcription, transformation, cell growth, and apoptosis and are characterized by the presence of the protein PML. The activities of PML as a tumor suppressor and apoptosis inducing factor are exerted through the numerous proteins it interacts with in the PML-nuclear bodies including the tumor suppressor p53. DNA damage induced activation of p53-dependent apoptosis requires PML. PML acts as a coactivator for p53 and increases acetylation of p53 by the transcriptional coactivator CBP. This acetylation of p53 is reversed by the deacetylase SirT1, the human homolog of the yeast gene Sir2, and this deacetylation opposes the transcriptional activation of p53. The tumor suppressor Rb also interacts with the PML nuclear body, increasing transcriptional repression of genes involved in cell cycle progression, suggesting that PML may affect cellular transformation through more than one mechanism. PML interacts directly with Ubc9, which modifies PML through the attachment of the ubiquitin-like peptide Sumo-1. Sumo-1 modification of PML is not necessary for the nuclear bodies to form, but may affect the recruitment of proteins that interact with PML. PML is involved in non-p53 mediated apoptotic pathways, such as DAXX-mediated apoptosis induced by Fas and TNF and regulates the transcriptional repressor activity of Daxx. The sequestration of Daxx by the PML nuclear bodies relieves the repression of other transcription factors like Pax3 by Daxx. Tumor suppression by PML may in general involve the formation of specific regulatory transcription complexes, including those with DAXX, p53 and CBP. Factors that affect the assembly of PML into the PML nuclear bodies affect the proliferation and transformation of cells. Viral early proteins can interact with PML to disrupt the nuclear bodies, allowing increased proliferation of cells and reduced apoptosis, good conditions for DNA virus infection. Another factor that disrupts the formation of PML nuclear bodies is a translocation between the PML and RAR-alpha genes found in acute promyelocytic leukemia (APL) patients. Binding of retinoic acid to the RAR-alpha steroid hormone receptor activates transcription of retinoic-acid responsive genes. The translocation found in APL patients creates two chimeric proteins, RARalpha-PML and PML-RARalpha. Retinoic acid given to APL patients causes the reappearance of nuclear bodies, and the reversal of cellular transformation, effecting a cure for these patients. More... |

Gene | Interactor | Interactor in MK4MDD? | Experiment Type | PMID | |
---|---|---|---|---|---|
SIRT1 | TP53 | No | in vitro;in vivo | 11672523 | |
SIRT1 | HIC1 | No | in vivo | 16269335 | |
SIRT1 | HEY2 | No | in vitro;in vivo | 12535671 | |
SIRT1 | PPARGC1A | No | in vitro;in vivo | 15744310 | |
SIRT1 | NR1H2 | No | in vivo | 17936707 | |
SIRT1 | FOXO3 | No | in vitro;in vivo;yeast 2-hybrid | 14976264 | |
SIRT1 | HES1 | No | in vivo | 12535671 | |
SIRT1 | NR1H3 | No | in vivo | 17936707 | |
SIRT1 | EP300 | Yes | in vitro;in vivo | 15632193 | |
SIRT1 | FOXO1 | No | in vivo | 15692560 | |
SIRT1 | HNF4A | No | in vivo | 15744310 | |
SIRT1 | HIST1H1B | No | in vitro | 15469825 | |
SIRT1 | RELA | No | in vivo | 15152190 | |
SIRT1 | RRP8 | No | in vivo | 18485871 |