Gene Report

Basic Information

Approved Symbol	NUP62
Approved Name	nucleoporin 62kDa
Previous Name	nucleoporin 62kD
Symbol Alias	p62, DKFZp547L134, IBSN, SNDI, MGC841, FLJ20822, FLJ43869
Name Alias	nuclear pore glycoprotein p62
Location	19
Position	chr19:50410082-50432988 (-)
External Links	Entrez Gene: 23636 Ensembl: ENSG00000213024 UCSC: uc002pqx.3 HGNC ID: 8066
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between NUP62 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
Nucleoporin 62 kDa	Tochigi, 2008	patients and normal controls		Genes differentially expressed in major depression Genes differentially expressed in major depression

Positive relationships between NUP62 and other components at different levels (count: 0)

Positive relationship network of NUP62 in MK4MDD

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between NUP62 and MDD (count: 0)

Negative relationships between NUP62 and other components at different levels (count: 0)

NUP62 related SNPs in MK4MDD (count: 0)

NUP62 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Nuclear pore glycoprotein p62	P37198	0(0/0)	Gene mapped

NUP62 related GO terms (count: 40)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0031965	nuclear membrane	cellular component	IDA
GO:0009966	regulation of signal transduction	biological process	NAS[8702753]
GO:0005515	protein binding	molecular function	IPI
GO:0016032	viral reproduction	biological process	TAS
GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	biological process	NAS[11244088]
GO:0043130	ubiquitin binding	molecular function	IDA[8702753]; ISS
GO:0005737	cytoplasm	cellular component	NAS[10373430]
GO:0055085	transmembrane transport	biological process	TAS
GO:0009755	hormone-mediated signaling pathway	biological process	NAS[15625236]
GO:0031074	nucleocytoplasmic shuttling complex	cellular component	NAS[8589458]
GO:0015758	glucose transport	biological process	TAS
GO:0043231	intracellular membrane-bounded organelle	cellular component	IDA
GO:0008285	negative regulation of cell proliferation	biological process	IDA[11013214]; ISS
GO:0043066	negative regulation of apoptotic process	biological process	IDA[11755531]; ISS
GO:0005975	carbohydrate metabolic process	biological process	TAS
GO:0000922	spindle pole	cellular component	IEA
GO:0046930	pore complex	cellular component	NAS[15175862]
GO:0010827	regulation of glucose transport	biological process	TAS
GO:0005635	nuclear envelope	cellular component	IDA; TAS
GO:0030529	ribonucleoprotein complex	cellular component	IDA[18809582]
GO:0046966	thyroid hormone receptor binding	molecular function	IPI[15625236]; ISS
GO:0030159	receptor signaling complex scaffold activity	molecular function	IDA[11244088]; ISS
GO:0007166	cell surface receptor signaling pathway	biological process	IDA[10799545]; ISS; NAS[10373430]
GO:0042169	SH2 domain binding	molecular function	IDA[8650207]; ISS
GO:0006913	nucleocytoplasmic transport	biological process	NAS[8589458]
GO:0044281	small molecule metabolic process	biological process	TAS
GO:0045893	positive regulation of transcription, DNA-dependent	biological process	IDA[15625236]; ISS
GO:0019221	cytokine-mediated signaling pathway	biological process	TAS
GO:0005487	nucleocytoplasmic transporter activity	molecular function	NAS[8589458]
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	biological process	IDA[10356400]; ISS
GO:0017056	structural constituent of nuclear pore	molecular function	IEA
GO:0051028	mRNA transport	biological process	IEA
GO:0003682	chromatin binding	molecular function	NAS[11852044]
GO:0008219	cell death	biological process	IMP[11244088]; ISS
GO:0006351	transcription, DNA-dependent	biological process	IDA[10373430]; ISS
GO:0005643	nuclear pore	cellular component	IDA[1915414]; ISS
GO:0043069	negative regulation of programmed cell death	biological process	IDA[11244088]; ISS
GO:0046578	regulation of Ras protein signal transduction	biological process	NAS[11553620]
GO:0008645	hexose transport	biological process	TAS
GO:0015031	protein transport	biological process	IEA

NUP62 related KEGG pathways (count: 0)

NUP62 related BioCarta pathways (count: 0)

NUP62 related Reactome pathways (count: 20)

ID	Name	Description
Gene mapped Reactome pathways
REACT_6145	influenza life_cycle	The virus particle initially associates with a human host ce...... The virus particle initially associates with a human host cell by binding to sialic acid-containing receptors on the host cell surface. The bound virus is endocytosed by one of four distinct mechanisms. The low endosomal pH sets in motion a number of steps that lead to viral membrane fusion mediated by the viral hemagglutinin (HA) protein, and the eventual release of the uncoated viral ribonucleoprotein complex into the cytosol of the host cell. The ribonucleoprotein complex is transported through the nuclear pore into the nucleus. Once in the nucleus, the incoming negative-sense viral RNA (vRNA) is transcribed into messenger RNA (mRNA) by a primer-dependent mechanism. Replication occurs via a two step process. A full-length complementary RNA (cRNA), a positive-sense copy of the vRNA, is first made and this in turn is used as a template to produce more vRNA. The viral proteins are expressed and processed and eventually assemble with vRNAs at budding sites within the host cell membrane. The viral protein complexes and ribonucleoproteins are assembled into viral particles and bud from the host cell, enveloped in the host cell's membrane. This release contains a framework for the further annotation of the viral life-cycle. More...
REACT_6256	hiv life_cycle	The life cycle of HIV-1 is divided into early and late phase...... The life cycle of HIV-1 is divided into early and late phases, shown schematically in the figure. In the early phase, an HIV-1 virion binds to receptors and co-receptors on the human host cell surface. Most of the crucial concepts used to describe these processes were originally elucidated in studies of retroviruses associated with tumors in chickens, birds, and other animal model systems, and the rapid elucidation of the basic features of the HIV-1 life cycle was critically dependent on the intellectual framework provided by these earlier studies. This earlier work has been very well summarized ; here for brevity and clarity we focus on experimental studies specific to the HIV-1 life cycle. More...
REACT_424	transport of_the_slbp_independent_mature_mrna	Transport of the SLBP independent Mature mRNA through the nu...... Transport of the SLBP independent Mature mRNA through the nuclear pore. More...
REACT_1597	transport of_mature_mrna_derived_from_an_intron_containing_transcript	Transport of mRNA from the nucleus to the cytoplasm, where i...... Transport of mRNA from the nucleus to the cytoplasm, where it is translated into protein, is highly selective and closely coupled to correct RNA processing. This coupling is achieved by the nuclear pore complex, which recognizes and transports only completed mRNAs. More...
REACT_6185	hiv infection	The global pandemic of Human Immunodeficiency Virus. HIV-1 a...... The global pandemic of Human Immunodeficiency Virus. HIV-1 and the less common HIV-2 belong to the family of retroviruses. HIV-1 contains a single-stranded RNA genome that is 9 kilobases in length and contains 9 genes that encode 15 different proteins. These proteins are classified as: structural proteins. HIV infection cycle can be divided into two phases: 1. An Early phase consisting of early events occuring after HIV infection of a susceptible target cell and a 2. Late phase comprising the later events in the HIV-infected cell resulting in the assembly of new infectious virions. The section titled HIV lifecycle consists of annotations of events in these two phases. The virus has developed various molecular strategies to suppress the antiviral immune responses. The section titled Host interactions of HIV factors will highlight these complex post-infection processes and the annotations will be released in near future. More...
REACT_7991	vpr mediated_nuclear_import_of_pics	Vpr appears to function in anchoring the PIC to the nuclear ...... Vpr appears to function in anchoring the PIC to the nuclear envelope. This anchoring likely involves interactions between Vpr and host nucleoporins. More...
REACT_6190	rev mediated_nuclear_export_of_hiv1_rna	The HIV-1 genome contains 9 genes encoded by a single transc...... The HIV-1 genome contains 9 genes encoded by a single transcript. In order for the virus to replicate, unspliced, singly-spliced and fully spliced viral mRNA must be exported from the nucleus. The HIV-1 mRNA splice sites are inefficient resulting it the accumulation of a pool of incompletely spliced RNAs. In the early stages of the viral life cycle, or in the absence of the viral Rev protein, completely spliced viral mRNA which encode the regulatory proteins Tat, Nef and Rev are exported from the nucleus while the incompletely spliced structural protein encoding transcripts are held within the nucleus by cellular proteins that normally function in preventing the nuclear export of cellular pre-mRNA. Export of both unspliced and partially spliced mRNA is mediated by the viral protein Rev which is recruited, along with cellular cofactors, to the Rev Response Element. The cellular hRIP protein is essential for correct Rev-mediated export of viral RNAs to the cytoplasm. More...
REACT_125	processing of_capped_intron_containing_pre_mrna	Any covalent change in a primary (nascent) mRNA transcript i...... Any covalent change in a primary (nascent) mRNA transcript is mRNA Processing. For successful gene expression, the primary mRNA transcript needs to be converted to a mature mRNA prior to its translation into polypeptide. Eucaryotic mRNAs undergo a series of complex processing reactions; these begin on nascent transcripts as soon as a few ribonucleotides have been synthesized during transcription by RNA Polymerase II, through the export of the mature mRNA to the cytoplasm, and culminate with mRNA turnover in the cytoplasm. More...
REACT_6804	regulation of_glucokinase_by_glucokinase_regulatory_protein	Glucokinase. Glucokinase.
REACT_212	glucose transport	Cells take up glucose by facilitated diffusion, via glucose ...... Cells take up glucose by facilitated diffusion, via glucose transporters (GLUTs) associated with the plasma membrane, a reversible reaction. Four tissue-specific GLUT isoforms are known. Glucose in the cytosol is phosphorylated by tissue-specific kinases to yield glucose 6-phosphate, which cannot cross the plasma membrane because of its negative charge. In the liver, this reaction is catalyzed by glucokinase which has a low affinity for glucose (Km about 10 mM) but is not inhibited by glucose 6-phosphate. In other tissues, this reaction is catalyzed by isoforms of hexokinase. Hexokinases are feedback-inhibited by glucose 6-phosphate and have a high affinity for glucose (Km about 0.1 mM). Liver cells can thus accumulate large amounts of glucose 6-phosphate but only when blood glucose concentrations are high, while most other tissues can take up glucose even when blood glucose concentrations are low but cannot accumulate much intracellular glucose 6-phosphate. These differences are consistent with the view that that the liver functions to buffer blood glucose concentrations, while most other tissues take up glucose to meet immediate metabolic needs. Glucose 6-phosphatase, expressed in liver and kidney, allows glucose 6-phosphate generated by gluconeogenesis (both tissues) and glycogen breakdown (liver) to leave the cell. The absence of glucose 6-phosphatase from other tissues makes glucose uptake by these tissues essentially irreversible, consistent with the view that cells in these tissues take up glucose for local metabolic use. More...
REACT_15518	transmembrane transport_of_small_molecules
REACT_9395	nuclear import_of_rev_protein	Nuclear import of Rev involves the cellular proteins includi...... Nuclear import of Rev involves the cellular proteins including importin-beta and B23 and is mediated by an arginine-rich nuclear localization signal (NLS) within the RNA binding domain of the Rev protein. The NLS of Rev associates with importin- beta as well as B23 which has been shown to function in the nuclear import of ribosomal proteins. The Rev-importin -B23 complex associates with the nuclear pore through interactions between importin and nucleoporin. Upon entry into the nucleus, Ran-GTP associates with importin resulting in in the disassembly of the importin -Rev-B23 complex and the release of Rev cargo. More...
REACT_11066	snrnp assembly	Small nuclear ribonucleoproteins (snRNPs) are crucial for pr...... Small nuclear ribonucleoproteins (snRNPs) are crucial for pre-mRNA processing to mRNAs. Each snRNP contains a small nuclear RNA (snRNA) and an extremely stable core of seven Sm proteins. The U6 snRNA differs from the other snRNAs; it binds seven Sm-like proteins and its assembly does not involve a cytoplasmic phase. The snRNP biogenesis pathway for all of the other snRNAs is complex, involving nuclear export of snRNA, Sm-core assembly in the cytoplasm and re-import of the mature snRNP. The assembly of the snRNA:Sm-core is carried out by the survival of motor neurons (SMN) complex. The SMN complex stringently scrutinizes RNAs for specific features that define them as snRNAs and binds the RNA-binding Sm proteins. More...
REACT_6288	host interactions_of_hiv_factors	Like all viruses, HIV-1 must co-opt the host cell macromolec...... Like all viruses, HIV-1 must co-opt the host cell macromolecular transport and processing machinery. HIV-1 Vpr and Rev proteins play key roles in this co-optation. Efficient HIV-1 replication likewise requires evasion of APOBEC3G-mediated mutagenesis of reverse transcripts, a process mediated by the viral Vif protein. More...
REACT_6248	transport of_ribonucleoproteins_into_the_host_nucleus	An unusual characteristic of the influenza virus life cycle ...... An unusual characteristic of the influenza virus life cycle is its dependence on the nucleus. Trafficking of the viral genome into and out of the nucleus is a tightly regulated process with all viral RNA synthesis occurring in the nucleus. The eight influenza virus genome segments never exist as naked RNA but are associated with four viral proteins to form viral ribonucleoprotein complexes. However the signals on NP have been shown to be both sufficient and necessary for the import of viral RNA. More...
REACT_21257	metabolism of_rna
REACT_474	metabolism of_carbohydrates	These pathways together are responsible for: 1) the extracti...... These pathways together are responsible for: 1) the extraction of energy and carbon skeletons for biosyntheses from dietary sugars and related molecules; 2) the short-term storage of glucose in the body (as glycogen) and its mobilization during a short fast; and 3) the synthesis of glucose from pyruvate during extended fasts. More...
REACT_71	gene expression	Gene Expression covers the process of transcription of mRNA ...... Gene Expression covers the process of transcription of mRNA genes, the processing of pre-mRNA, and its subsequent translation to result in a protein. The expression of non-protein-coding genes is not included in this section yet. However, the transcription of RNAs other than mRNA is described in the section on transcription; in the sections 'RNA Polymerase I Transcription', and 'RNA Polymerase III Transcription'. More...
REACT_6179	nep ns2_interacts_with_the_cellular_export_machinery	The viral RNP complex is exported from the nucleus via the h...... The viral RNP complex is exported from the nucleus via the host cell CRM1 export pathway. The vRNP complex does not interact directly with CRM1 to form an export complex. Rather, an additional viral protein, nuclear export protein. The CRM1/exportin-1 complex recruits additional host cell proteins, and traverses the nuclear pore into the cytosol. More...
REACT_6361	late phase_of_hiv_life_cycle	The late phase of the HIV-1 life cycle includes the regulate...... The late phase of the HIV-1 life cycle includes the regulated expression of the HIV gene products and the assembly of viral particles. The assembly of viral particles will be covered in a later release of Reactome. HIV-1 gene expression is regulated by both cellular and viral proteins. Although the initial activation of the HIV-1 transcription is facilitated by cellular transcription factors including NF-kappa B , this activation results in the production of primarily short transcripts. Expression of high levels of the full length HIV-1 transcript requires the function of the HIV-1 Tat protein which promotes elongation of the HIV-1 transcript. The HIV-1 Rev protein is required post-transcriptionally for the expression of the late genes. Rev functions by promoting the nuclear export of unspliced and partially spliced transcripts that encode the major structural proteins Gag, Pol and Env, and the majority of the accessory proteins (Malim et al., 1989; reviewed in Pollard and Malim 1998. More...

NUP62 related interactors from protein-protein interaction data in HPRD (count: 24)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
NUP62	RANBP2	No	in vitro	11266456
NUP62	TRAF3	No	in vitro;in vivo;yeast 2-hybrid	10781837
NUP62	NUP54	No	yeast 2-hybrid	16189514
NUP62	GTF2E2	No	in vitro	11113176
NUP62	NUP98	No	in vitro	8707840
NUP62	PBX2	No	yeast 2-hybrid	14667819
NUP62	KPNB1	No	in vitro	9102465
NUP62	GORASP2	No	yeast 2-hybrid	16189514
NUP62	XPO1	No	in vitro;in vivo	10330396
NUP62	HSF2	No	in vitro;yeast 2-hybrid	9367915
NUP62	XPO6	No	yeast 2-hybrid	16189514
NUP62	PTMA	No	in vitro	11310559
NUP62	NXF1	No	in vitro	10668806
NUP62	DTNB	No	yeast 2-hybrid	16189514
NUP62	NUP62	Yes	in vitro	11266456
NUP62	THAP1	No	yeast 2-hybrid	16189514
NUP62	NUPL1	No	in vitro	11266456
NUP62	DDX3X	No	in vivo	15507209
NUP62	NXF2	No	in vitro	11073998
NUP62	NUP153	No	in vitro	11266456
NUP62	CCDC53	No	yeast 2-hybrid	16189514
NUP62	IK	No	yeast 2-hybrid	16169070
NUP62	NUTF2	No	in vitro	15522285 , 7744965 , 8757804
NUP62	IPO5	No	in vitro;in vivo	9114010

Gene Report

Gene mapped GO terms

Gene mapped Reactome pathways