MK4MDD

Gene Report

Basic Information
Approved Symbol CTLA4
Approved Name cytotoxic T-lymphocyte-associated protein 4
Previous Symbol CELIAC3, IDDM12
Previous Name "celiac disease 3", "insulin-dependent diabetes mellitus 12"
Symbol Alias CD152, CD, GSE, CD28, ICOS
Location 2q33
Position chr2:204738093-204738683 (+)
External Links Entrez Gene: 1493
Ensembl: ENSG00000163599
UCSC: uc002vak.2
HGNC ID: 2505
No. of Studies (Positive/Negative) 2(1/1) Help
Type Literature-origin

Positive relationships between CTLA4 and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description Help
cytotoxic T lymphocyte antigen-4 (CTLA-4) Liu, 2011 patients and normal controls P-value<0.01 Rs231779 in this gene conferred a risk for major depressive ...... Rs231779 in this gene conferred a risk for major depressive disorder (P(allele)=0.0006, P(genotype)=0.0026) More...

Positive relationships between CTLA4 and other components at different levels (count: 0) Help
Positive relationship network of CTLA4 in MK4MDD
Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between CTLA4 and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description
CTLA-4 Jun TY, 2001 Patients and nomal controls There were no significant differences in genotype frequenci...... There were no significant differences in genotype frequencies of CTLA-4*G/G, CTLA-4*G/A, and CTLA-4*A/A between the patients with major depression and the control group in the Korean population (48.1% vs. 46.3%, 41.6% vs 39.6%, 10.3% vs. 14.1%, respectively). There were no significant differences in allelic frequencies of CTLA-4*G and CTLA-4*A between the patients with major depression and the control group in the Korean population (68.8% vs. 66.1%, 31.2% vs. 33.9%, respectively). More...

Negative relationships between CTLA4 and other components at different levels (count: 0) Help
CTLA4 related SNPs in MK4MDD (count: 0)
CTLA4 related proteins in MK4MDD (count: 0)
CTLA4 related GO terms (count: 15)
CTLA4 related KEGG pathways (count: 3)
CTLA4 related BioCarta pathways (count: 1)
CTLA4 related Reactome pathways (count: 3)
CTLA4 related interactors from protein-protein interaction data in HPRD (count: 15)