Gene Report

Basic Information

Approved Symbol	SEMA3F
Approved Name	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
Symbol Alias	SEMAK, Sema4
Name Alias	"sema IV"
Location	3p21.3
Position	chr3:50225549-50226508 (+)
External Links	Entrez Gene: 6405 Ensembl: ENSG00000001617 UCSC: uc003cyj.3 HGNC ID: 10728
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between SEMA3F and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
Semaphorin 3F	Thomas, 2002	patients and normal controls		Genes differentially expressed in major depression Genes differentially expressed in major depression

Positive relationships between SEMA3F and other components at different levels (count: 0)

Positive relationship network of SEMA3F in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between SEMA3F and MDD (count: 0)

Negative relationships between SEMA3F and other components at different levels (count: 0)

SEMA3F related SNPs in MK4MDD (count: 0)

SEMA3F related proteins in MK4MDD (count: 0)

SEMA3F related GO terms (count: 22)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0048846	axon extension involved in axon guidance	biological process	ISS
GO:0021612	facial nerve structural organization	biological process	IEA
GO:1902285	semaphorin-plexin signaling pathway involved in neuron projection guidance	biological process	ISS
GO:0007411	axon guidance	biological process	IDA[15814794]
GO:0061549	sympathetic ganglion development	biological process	ISS
GO:0001755	neural crest cell migration	biological process	IBA
GO:0021637	trigeminal nerve structural organization	biological process	IEA
GO:0045499	chemorepellent activity	molecular function	IDA[15814794]
GO:0097490	sympathetic neuron projection extension	biological process	ISS
GO:0021785	branchiomotor neuron axon guidance	biological process	IEA
GO:0038191	neuropilin binding	molecular function	IBA
GO:0036486	ventral trunk neural crest cell migration	biological process	IEA
GO:1902287	semaphorin-plexin signaling pathway involved in axon guidance	biological process	IEA
GO:0050919	negative chemotaxis	biological process	IEA
GO:0048843	negative regulation of axon extension involved in axon guidance	biological process	IBA
GO:0071526	semaphorin-plexin signaling pathway	biological process	IBA
GO:0005615	extracellular space	cellular component	TAS[8786119]
GO:0021675	nerve development	biological process	ISS
GO:0097491	sympathetic neuron projection guidance	biological process	ISS
GO:0030215	semaphorin receptor binding	molecular function	IBA
GO:0030335	positive regulation of cell migration	biological process	IBA
GO:1901166	neural crest cell migration involved in autonomic nervous system development	biological process	IEA

SEMA3F related KEGG pathways (count: 1)

ID	Name	Brief Description	Full Description
Literature-origin KEGG pathway
hsa04360	axon guidance	Axon guidance	Axon guidance represents a key stage in the formation of neu...... Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn. More...

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways

SEMA3F related BioCarta pathways (count: 0)

SEMA3F related Reactome pathways (count: 0)

SEMA3F related interactors from protein-protein interaction data in HPRD (count: 6)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
SEMA3F	NRP1	Yes	in vitro;in vivo	9883722
SEMA3F	VEGFA	Yes	in vitro;in vivo	12845630
SEMA3F	NRP2	No	in vitro;in vivo	9883722
SEMA3F	SHBG	No	yeast 2-hybrid	15862967
SEMA3F	TMEM22	No	yeast 2-hybrid	16169070
SEMA3F	UBA1	No	yeast 2-hybrid	16169070

Gene Report

Gene mapped GO terms

Literature-origin KEGG pathway

Gene mapped KEGG pathways