Gene Report

Basic Information

Approved Symbol	RAB27B
Approved Name	RAB27B, member RAS oncogene family
Location	18q21.2
Position	chr18:52556645-52562747 (+)
External Links	Entrez Gene: 5874 Ensembl: ENSG00000041353 UCSC: uc002lfr.3 HGNC ID: 9767
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between RAB27B and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
RAB27B	Sibille E, 2009	animal model; patients and nomal controls	R=0.88, P-value<5E-6; y slope=1.13	Upregulated in MDD patients Upregulated in MDD patients

Positive relationships between RAB27B and other components at different levels (count: 0)

Positive relationship network of RAB27B in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between RAB27B and MDD (count: 0)

Negative relationships between RAB27B and other components at different levels (count: 0)

RAB27B related SNPs in MK4MDD (count: 0)

RAB27B related proteins in MK4MDD (count: 0)

RAB27B related GO terms (count: 20)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0042589	zymogen granule membrane	cellular component	IEA
GO:0045921	positive regulation of exocytosis	biological process	IMP[19966785]
GO:0019904	protein domain specific binding	molecular function	IPI[16880209]
GO:0005795	Golgi stack	cellular component	IDA[19966785]
GO:0016324	apical plasma membrane	cellular component	IEA
GO:0042470	melanosome	cellular component	IDA[15357836]
GO:0007264	small GTPase mediated signal transduction	biological process	IEA
GO:0003924	GTPase activity	molecular function	ISS
GO:0071985	multivesicular body sorting pathway	biological process	IMP[19966785]
GO:0005525	GTP binding	molecular function	IDA[9066979]; ISS
GO:0032585	multivesicular body membrane	cellular component	IDA[19966785]
GO:0005515	protein binding	molecular function	IPI[15357836\|25416956]
GO:0015031	protein transport	biological process	IEA
GO:0032553	ribonucleotide binding	molecular function	ISS
GO:0030140	trans-Golgi network transport vesicle	cellular component	IDA[19966785]
GO:0030141	secretory granule	cellular component	IBA
GO:0019003	GDP binding	molecular function	IDA[20937701]
GO:0031489	myosin V binding	molecular function	IPI[15357836]
GO:0070062	extracellular exosome	cellular component	IDA[19199708\|23376485\|23533145]
GO:0032402	melanosome transport	biological process	IBA

RAB27B related KEGG pathways (count: 0)

RAB27B related BioCarta pathways (count: 0)

RAB27B related Reactome pathways (count: 0)

RAB27B related interactors from protein-protein interaction data in HPRD (count: 4)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
RAB27B	MLPH	No	in vivo	11856727
RAB27B	RPH3AL	No	in vivo	12578829
RAB27B	UNC13D	No	in vitro	14699162
RAB27B	SYTL4	No	in vitro;in vivo	11956164

Gene Report

Gene mapped GO terms