Gene Report

Basic Information

Approved Symbol	RAB13
Approved Name	RAB13, member RAS oncogene family
Location	1q21.2
Position	chr1:153958713-153958853 (-)
External Links	Entrez Gene: 5872 Ensembl: ENSG00000143545 UCSC: uc001fdt.2 HGNC ID: 9762
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between RAB13 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
RAB13	Frodl, 2004	patients and normal controls		Genes differentially expressed in major depression Genes differentially expressed in major depression

Positive relationships between RAB13 and other components at different levels (count: 0)

Positive relationship network of RAB13 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between RAB13 and MDD (count: 0)

Negative relationships between RAB13 and other components at different levels (count: 0)

RAB13 related SNPs in MK4MDD (count: 0)

RAB13 related proteins in MK4MDD (count: 0)

RAB13 related GO terms (count: 36)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0032869	cellular response to insulin stimulus	biological process	ISS

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0016197	endosomal transport	biological process	IMP[18779367]
GO:0005525	GTP binding	molecular function	IDA[20937701]
GO:0005515	protein binding	molecular function	IPI[9712853\|16525024\|18332111\|20008558\|21795389\|23772379]
GO:0044795	trans-Golgi network to recycling endosome transport	biological process	ISS
GO:0030027	lamellipodium	cellular component	ISS
GO:0005923	bicellular tight junction	cellular component	IDA[8294494\|12058051]
GO:0090002	establishment of protein localization to plasma membrane	biological process	IMP[15096524]
GO:0097368	establishment of Sertoli cell barrier	biological process	ISS
GO:0006904	vesicle docking involved in exocytosis	biological process	IBA
GO:0034236	protein kinase A catalytic subunit binding	molecular function	IEA
GO:0055037	recycling endosome	cellular component	IDA[18779367]
GO:0043005	neuron projection	cellular component	IDA[20008558]
GO:0070062	extracellular exosome	cellular component	IDA[19056867]
GO:1902463	protein localization to cell leading edge	biological process	IEA
GO:0061024	membrane organization	biological process	TAS
GO:0016328	lateral plasma membrane	cellular component	IDA[12058051]
GO:0070830	bicellular tight junction assembly	biological process	IMP[12058051\|15096524]
GO:0030139	endocytic vesicle	cellular component	IDA[15528189]
GO:0005794	Golgi apparatus	cellular component	IDA[18779367]
GO:0005802	trans-Golgi network	cellular component	IDA[18779367]
GO:0009306	protein secretion	biological process	IBA
GO:0031410	cytoplasmic vesicle	cellular component	IDA[8294494]
GO:0055038	recycling endosome membrane	cellular component	IEA
GO:0003924	GTPase activity	molecular function	EXP
GO:0007264	small GTPase mediated signal transduction	biological process	IEA
GO:0030659	cytoplasmic vesicle membrane	cellular component	TAS
GO:0032456	endocytic recycling	biological process	IMP[15528189]
GO:0005737	cytoplasm	cellular component	IDA
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0032593	insulin-responsive compartment	cellular component	ISS
GO:0005886	plasma membrane	cellular component	IDA[15528189\|18779367]
GO:0035767	endothelial cell chemotaxis	biological process	ISS
GO:0030866	cortical actin cytoskeleton organization	biological process	ISS
GO:0031175	neuron projection development	biological process	IMP[20008558]
GO:0010737	protein kinase A signaling	biological process	IMP[15096524]

RAB13 related KEGG pathways (count: 1)

ID	Name	Brief Description	Full Description
Literature-origin KEGG pathway
hsa04530	tight junction	Tight junction	Epithelial tight junctions (TJs) are composed of at least th...... Epithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. The transmembrane proteins mediate cell adhesion and are thought to constitute the intramembrane and paracellular diffusion barriers. The cytoplasmic 'plaque' contains three major multi-protein complexes consisting largely of scaffolding proteins, the ZO protein complex, the CRB3-Pals1-PATJ complex and the PAR-3-aPKC-PAR-6 complex. The ZO protein complex appears to organize the transmembrane proteins and couple them to other cytoplasmic proteins and to actin microfilaments. Two evolutionarily conserved protein complexes, the CRB3 and PAR complexes are involved in the establishment and maintenance of epithelial cell polarity. Besides these three protein complexes which seem to be constitutively associated at TJs, a number of proteins with different functions has been identified at TJs. These include additional scaffolding proteins like MUPP1 and MAGI-1, adaptor proteins, transcription regulators and RNA processing factors, regulatory proteins like small GTPases and G-proteins, kinases and phosphatases, and heat shock proteins. These are proposed to be involved in junction assembly, barrier regulation, gene transcription, and perhaps other, presently undefined pathways. More...

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways

RAB13 related BioCarta pathways (count: 0)

RAB13 related Reactome pathways (count: 0)

RAB13 related interactors from protein-protein interaction data in HPRD (count: 4)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
RAB13	PDE6D	No	in vitro;in vivo;yeast 2-hybrid	9712853
RAB13	TGFBR1	No	in vivo	15761153
RAB13	SMURF2	No	in vivo	15761153
RAB13	SMAD4	No	in vivo	15761153

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Literature-origin KEGG pathway

Gene mapped KEGG pathways