Gene Report

Basic Information

Approved Symbol	PRIMA1
Approved Name	proline rich membrane anchor 1
Symbol Alias	PRIMA
Name Alias	"membrane anchor of acetylcholinesterase"
Location	14q32.13
Position	chr14:94254756-94254766 (-)
External Links	Entrez Gene: 145270 Ensembl: ENSG00000175785 UCSC: uc001ybw.1 HGNC ID: 18319
No. of Studies (Positive/Negative)	1(0/1)
Type	Literature-origin

Positive relationships between PRIMA1 and MDD (count: 0)

Positive relationships between PRIMA1 and other components at different levels (count: 0)

Positive relationship network of PRIMA1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between PRIMA1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
PRIMA1	Sabunciyan S, 2012	patients and nomal controls	mRNA P value = 0.047; methylation P value = 0.0006¨C0.01	we tested mRNA levels of the gene in the same brain samples ...... we tested mRNA levels of the gene in the same brain samples that were used for the DNAm experiments. Levels were altered in the MDD brain samples in the expected direction,being decreased 53% (p = 0.047).We used DNA from these subjects¡¯ lymphoblastoid cell lines and saw results similar to those in brain. DNAm was increased in MDD subjects as compared to controls (by 7¨C10%, p = 0.0006¨C0.01) for three of the four PRIMA1 CpGs More...

Negative relationships between PRIMA1 and other components at different levels (count: 0)

PRIMA1 related SNPs in MK4MDD (count: 0)

PRIMA1 related proteins in MK4MDD (count: 0)

PRIMA1 related GO terms (count: 8)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0030054	cell junction	cellular component	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0045202	synapse	cellular component	IEA
GO:0031226	intrinsic component of plasma membrane	cellular component	IEA
GO:0042135	neurotransmitter catabolic process	biological process	IEA
GO:0016021	integral component of membrane	cellular component	IEA
GO:0019899	enzyme binding	molecular function	IEA
GO:0051649	establishment of localization in cell	biological process	IEA
GO:0043495	protein anchor	molecular function	IEA

PRIMA1 related KEGG pathways (count: 0)

PRIMA1 related BioCarta pathways (count: 0)

PRIMA1 related Reactome pathways (count: 0)

PRIMA1 related interactors from protein-protein interaction data in HPRD (count: 1)

Gene Report

Literature-origin GO terms

Gene mapped GO terms