MK4MDD

Gene Report

Basic Information
Approved Symbol PRIMA1
Approved Name proline rich membrane anchor 1
Symbol Alias PRIMA
Name Alias "membrane anchor of acetylcholinesterase"
Location 14q32.13
Position chr14:94254756-94254766 (-)
External Links Entrez Gene: 145270
Ensembl: ENSG00000175785
UCSC: uc001ybw.1
HGNC ID: 18319
No. of Studies (Positive/Negative) 1(0/1) Help
Type Literature-origin

Positive relationships between PRIMA1 and MDD (count: 0)
Positive relationships between PRIMA1 and other components at different levels (count: 0) Help
Positive relationship network of PRIMA1 in MK4MDD
Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between PRIMA1 and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description
PRIMA1 Sabunciyan S, 2012 patients and nomal controls mRNA P value = 0.047; methylation P value = 0.0006¨C0.01 we tested mRNA levels of the gene in the same brain samples ...... we tested mRNA levels of the gene in the same brain samples that were used for the DNAm experiments. Levels were altered in the MDD brain samples in the expected direction,being decreased 53% (p = 0.047).We used DNA from these subjects¡¯ lymphoblastoid cell lines and saw results similar to those in brain. DNAm was increased in MDD subjects as compared to controls (by 7¨C10%, p = 0.0006¨C0.01) for three of the four PRIMA1 CpGs More...

Negative relationships between PRIMA1 and other components at different levels (count: 0) Help
PRIMA1 related SNPs in MK4MDD (count: 0)
PRIMA1 related proteins in MK4MDD (count: 0)
PRIMA1 related GO terms (count: 8)
PRIMA1 related KEGG pathways (count: 0)
PRIMA1 related BioCarta pathways (count: 0)
PRIMA1 related Reactome pathways (count: 0)
PRIMA1 related interactors from protein-protein interaction data in HPRD (count: 1)