Gene Report

Basic Information

Approved Symbol	CAT
Approved Name	catalase
Location	11p13
Position	chr11:34492981-34493607 (+)
External Links	Entrez Gene: 847 Ensembl: ENSG00000121691 UCSC: uc001mvm.3 HGNC ID: 1516
No. of Studies (Positive/Negative)	2(1/1)
Type	Literature-origin

Positive relationships between CAT and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
CAT	Klempan, 2009	patients and normal controls		Selected differentially expressed genes in BA44 to BA47 (ANO...... Selected differentially expressed genes in BA44 to BA47 (ANOVA and t-test P < 0.01, fold change 1.3t) More...

Positive relationships between CAT and other components at different levels (count: 0)

Positive relationship network of CAT in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between CAT and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
CAT	Redei, 2015	Patients and nomal controls		A set of 26 candidate blood transcriptomic markers was deriv...... A set of 26 candidate blood transcriptomic markers was derived from the animal studies, and an unbiased analysis of this panel was conducted in the blood of the MDD and ND adolescents.A panel of 11 blood markers differentiated participants with MDD from those with ND More...

Negative relationships between CAT and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description
Name in Literature	Related Components
CAT		anxiety disorder(anxiety disorder)	symptoms	Redei, 2015	Patients and nomal controls	effect-size=-0.55	On the basis of the hypothesis that chronic stress markers, ...... On the basis of the hypothesis that chronic stress markers, such as those developed from our CRS model, might also track anxiety-like states, we evaluated the possibility of differential expression of the transcript panel between those who were diagnosed with MDD with or without a comorbid anxiety disorder. This intragroup analysis revealed medium-to-large effect-size differences in 18 of the 26 candidate biomarkers.thus, the nonoverlapping candidates FAM46A, NAGA, TLR7, ZNF291/SCAPER, AHSP DGKA, GCLM,GGA3, IRF3, KIAA1539,and SLC4A1 are specific to MDDcomorbidwith anxiety.Theoverlapping transcripts CD59,IGSF4A/CADM1,AMFR,CAT,CDR2, CMAS,and PSME1 might represent transcriptomic alterations common to both major depression and anxiety disorders ormay represent a consistent alteration in EOMDD patients with depression regardless of comorbidities. More...

CAT related SNPs in MK4MDD (count: 0)

CAT related proteins in MK4MDD (count: 0)

CAT related GO terms (count: 66)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0016209	antioxidant activity	molecular function	IDA[10514471]

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	biological process	IEA
GO:0055093	response to hyperoxia	biological process	IEA
GO:0070542	response to fatty acid	biological process	IEA
GO:0005782	peroxisomal matrix	cellular component	TAS
GO:0071363	cellular response to growth factor stimulus	biological process	IEA
GO:0009060	aerobic respiration	biological process	IEA
GO:0005925	focal adhesion	cellular component	IDA[21423176]
GO:0006641	triglyceride metabolic process	biological process	IEA
GO:0019899	enzyme binding	molecular function	IPI[16781659]
GO:0051092	positive regulation of NF-kappaB transcription factor activity	biological process	IEA
GO:0005777	peroxisome	cellular component	IDA[2895531\|9053548\|18379038\|19479899]
GO:0007568	aging	biological process	IEA
GO:0044281	small molecule metabolic process	biological process	TAS
GO:0020027	hemoglobin metabolic process	biological process	IEA
GO:0020037	heme binding	molecular function	IDA[10656833\|11134921]
GO:0005758	mitochondrial intermembrane space	cellular component	IEA
GO:0005778	peroxisomal membrane	cellular component	ISS
GO:0005615	extracellular space	cellular component	IEA
GO:0001649	osteoblast differentiation	biological process	IDA[16210410]
GO:0080184	response to phenylpropanoid	biological process	IEA
GO:0042542	response to hydrogen peroxide	biological process	IBA
GO:0051262	protein tetramerization	biological process	IDA[10656833\|11134921]
GO:0098869	cellular oxidant detoxification	biological process	IDA[10514471\|16644728\|18312938\|18379038]; IEA; TAS
GO:0046872	metal ion binding	molecular function	IEA
GO:0000302	response to reactive oxygen species	biological process	IMP[16644728]; TAS
GO:0032355	response to estradiol	biological process	IEA
GO:0005102	receptor binding	molecular function	IPI[20178365\|21976670]
GO:0014823	response to activity	biological process	IEA
GO:0043231	intracellular membrane-bounded organelle	cellular component	IDA
GO:0051781	positive regulation of cell division	biological process	IEA
GO:0004096	catalase activity	molecular function	IDA[16644728\|18312938\|18379038]; TAS
GO:0005764	lysosome	cellular component	IEA
GO:0046686	response to cadmium ion	biological process	IEA
GO:0033591	response to L-ascorbic acid	biological process	IEA
GO:0004046	aminoacylase activity	molecular function	IEA
GO:0051289	protein homotetramerization	biological process	IDA[21976670]
GO:0042803	protein homodimerization activity	molecular function	IDA[10656833]
GO:0014854	response to inactivity	biological process	IEA
GO:0006144	purine nucleobase metabolic process	biological process	TAS
GO:0005829	cytosol	cellular component	IEA
GO:0033197	response to vitamin E	biological process	IEA
GO:0033189	response to vitamin A	biological process	IEA
GO:0009650	UV protection	biological process	IMP[16644728\|17053817]
GO:0009642	response to light intensity	biological process	IEA
GO:0042744	hydrogen peroxide catabolic process	biological process	IDA[18379038]
GO:0055086	nucleobase-containing small molecule metabolic process	biological process	TAS
GO:0001657	ureteric bud development	biological process	IEA
GO:0045471	response to ethanol	biological process	IEA
GO:0043066	negative regulation of apoptotic process	biological process	IMP[16644728]
GO:0032868	response to insulin	biological process	IEA
GO:0010288	response to lead ion	biological process	IEA
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	molecular function	ISS
GO:0042493	response to drug	biological process	IEA
GO:0001666	response to hypoxia	biological process	IEA
GO:0070062	extracellular exosome	cellular component	IDA[23376485\|23533145]
GO:0016020	membrane	cellular component	IDA[16210410\|19946888]
GO:0005886	plasma membrane	cellular component	IEA
GO:0006195	purine nucleotide catabolic process	biological process	TAS
GO:0032088	negative regulation of NF-kappaB transcription factor activity	biological process	IEA
GO:0008203	cholesterol metabolic process	biological process	IEA
GO:0050661	NADP binding	molecular function	IDA[10656833]
GO:0005794	Golgi apparatus	cellular component	IEA
GO:0010193	response to ozone	biological process	IEA
GO:0005739	mitochondrion	cellular component	IBA
GO:0005783	endoplasmic reticulum	cellular component	IEA

CAT related KEGG pathways (count: 3)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04146	peroxisome	Peroxisome	Peroxisomes are essential organelles that play a key role in...... Peroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification. The biogenesis of peroxisomes starts with the early peroxins PEX3, PEX16 and PEX19 and proceeds via several steps. The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. Peroxisomes' deficiencies lead to severe and often fatal inherited peroxisomal disorders (PD). PDs are usually classified in two groups. The first group is disorders of peroxisome biogenesis which include Zellweger syndrome, and the second group is single peroxisomal enzyme deficiencies. More...
hsa00380	tryptophan metabolism	Tryptophan metabolism
hsa05014	amyotrophic lateral_sclerosis_als	Amyotrophic lateral sclerosis (ALS)	Amyotrophic lateral sclerosis (ALS) is a progressive, lethal...... Amyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord, leading to paralysis of voluntary muscles. Mutant superoxide dismutase 1 (SOD1), as seen in some familial amyotrophic lateral sclerosis (FALS) cases, may be toxic because it is unstable, forming aggregates in the motor neuron cytoplasm, axoplasm and mitochondria. Within mitochondria, mutant SOD1 may interfere with the anti-apoptotic function of Bcl-2, affect mitochondrial import by interfering with the translocation machinery (TOM/TIM), and generate toxic free radicals (ROS) via aberrant superoxide chemistry. These changes may then result in abnormal mitochondrial energy metabolism, Ca2+ handling, and release of pro-apoptotic factors. Reactive oxygen species (ROS), produced within mitochondria, inhibit the function of EAAT2, the main glial glutamate transporter protein, responsible for most of the reuptake of synaptically released glutamate. Glutamate excess causes neurotoxicity by increasing intracellular calcium, which enhances oxidative stress and mitochondrial damage. Mutant SOD1 can also trigger oxidative reactions by various means including by increasing levels of peroxynitrite, which can then cause damage through the formation of hydroxyl radicals or via nitration of tyrosine residues on proteins. Nitration may target neurofilament proteins, disrupting their phosphorylation and affecting axonal transport. Collectively, these mechanisms (or a combination thereof) are predicted to disturb cellular homeostasis (within glial and/or motor neurons), ultimately triggering motor neuron death. More...

CAT related BioCarta pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped BioCarta pathways
LONGEVITY_PATHWAY	longevity pathway	The IGF-1 Receptor and Longevity	A demonstrated means to increase lifespan in a wide range of...... A demonstrated means to increase lifespan in a wide range of organisms is through the restriction of caloric intake. Reducing the consumption of calories increases the lifespan of many different organisms, including mice. Although caloric restriction has not been demonstrated experimentally to increase human lifespan, short-term changes in physiological measures like insulin responsiveness have been observed. Caloric restriction not only increases lifespan, but decreases age-related deterioration of systems and physiological responses, reducing age related diseases like cancer and neurodegenerative disease. Caloric restriction in animals reduces the levels of plasma glucose and insulin and reduces inflammatory responses and may reduce oxidative stress through reduced oxidative metabolism, further contributing to the health benefits of reduced calorie intake. The reduction in inflammation may be related to reduces plasma glucose and in humans could reduce an inflammation connection to cancer, heart disease, and Alzheimers disease. Genetic analysis has indicated several genes that influence lifespan, particularly those that alter pituitary development, reduce growth hormone secretion, reduce food intake, and reduce apoptosis (p66 Shc). All of these appear to converge on an IGF-1 receptor pathway and to reproduce many of the effects of caloric restriction. Although dwarf mice with defective growth hormone or IGF-1 signaling also have significantly increased lifespan, humans with defects in growth hormone signaling tend to develop diseases that shorten their lifespan. One of the downstream targets of IGF-1 signaling is to repress stress resistance proteins including antioxidant enzymes like superoxide dismutase, and heat shock proteins, so a reduction in IGF signaling may extend lifespan by increasing the expression of stress resistance genes. The link between caloric restriction and IGF signaling may be that a reduction in food intake reduces the expression of IGF-1, increasing the expression of stress resistance proteins. In addition to the IGF-1R mutation, p66 Shc mutation also increases lifespan without significant aberration of other systems. Shc is a target of IGF-1R phosphorylation, and a major inducer of cellular responses to oxidative stress. Shc increases levels of intracellular reactive oxygen species, repressing the forkhead factor FKHRL1. Alhtough FKHRL1 is also involved in apoptosis, in the absence of Shc, FKHRL1 mediates increased resistance to oxidative stress. Exploration of the genes that induce longevity in animals models may enlighten the role of these genes in human disease and lifespan. More...

CAT related Reactome pathways (count: 0)

CAT related interactors from protein-protein interaction data in HPRD (count: 5)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
CAT	CAT	Yes	in vitro	10656833 , 10666617 , 11134921
CAT	ABL2	No	in vitro;in vivo	12777400
CAT	TLR10	No	yeast 2-hybrid	16482509
CAT	PTPN11	No	in vitro	15556604
CAT	SUMO4	No	in vivo	16236267

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped BioCarta pathways