HOPA polymorphisms were associated with an increased risk fo......
HOPA polymorphisms were associated with an increased risk for major depression.More...
Positive relationships between MED12 and other components at different levels (count: 0)
Positive relationship network of MED12 in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus
Protein and Other Molecule
Cell and Molecular Pathway
Neural System
Cognition and Behavior
Symptoms and Signs
Environment
MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network.
If the mapped gene or protein is not from literature, square node would be used instead of Circle node.
Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node.
Right-click will show also the menus to link to the report page of the node and remove the node and related edges.
Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web
Negative relationships between MED12 and MDD (count: 0)
Negative relationships between MED12 and other components at different levels (count: 0)
OVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of ge......
OVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or tissue-specific regulation of differential gene transcription is mediated. Of the three major classes of DNA polymerase involved in eukaryotic gene transcription, Polymerase II generally regulates protein-encoding genes. Figure 1 shows a diagram of the various components involved in cell-specific regulation of Pol-II gene transcription. Core Promoter: Pol II-regulated genes typically have a Core Promoter where Pol II and a variety of general factors bind to specific DNA motifs: i: the TATA box and transcription repressor. The DRIP co-activator complex was originally identified and named as a specific complex associated with the Vitamin D Receptor member of the nuclear receptor family of transcription factors. Similarly, the TRAP co-activator complex was originally identified as a complex that associates with the thyroid receptor. It was later determined that all of the components of the DRIP complex are also present in the TRAP complex, and the ARC complex. In addition, these various transcription co-activator proteins identified in mammalian cells were found to be the orthologues or homologues of the Mediator. The Mediator proteins were originally identified in yeast by Kornberg and colleagues, as complexes associated with DNA polymerase. In higher organisms, Adapter complexes bridge between the basal transcription factors. For example, the DRIP205 / TRAP220 proteins are now identified as Mediator 1 , based on homology with yeast Mediator 1. Example Pathway: Specific Regulation of Target Genes During Notch Signaling: One well-studied example of cell-specific regulation of gene transcription is selective regulation of target genes during Notch signaling. Notch signaling was first identified in Drosophila, where it has been studied in detail at the genetic, molecular, biochemical and cellular levels. In Drosophila, Notch signaling to the nucleus is thought always to be mediated by one specific DNA binding transcription factor, Suppressor of Hairless. In mammals, the homologous genes are called CBF1. All three of the co-repressor proteins have been shown to be necessary for proper gene regulation during Notch signaling in vivo. In mammals, the same general pathway and mechanisms are observed, where CSL proteins are bifunctional DNA binding transcription factors. Thus, CSL is a good example of a bifunctional DNA-binding transcription factor that mediates repression of specific targets genes in one context, but activation of the same targets in another context. This bifunctionality is mediated by the association of specific Co-Repressor complexes vs. specific Co-Activator complexes in different contexts, namely in the absence or presence of Notch signaling.More...
Gene Expression covers the process of transcription of mRNA ......
Gene Expression covers the process of transcription of mRNA genes, the processing of pre-mRNA, and its subsequent translation to result in a protein. The expression of non-protein-coding genes is not included in this section yet. However, the transcription of RNAs other than mRNA is described in the section on transcription; in the sections 'RNA Polymerase I Transcription', and 'RNA Polymerase III Transcription'.More...
MED12 related interactors from protein-protein interaction data in HPRD (count: 9)