Gene Report

Basic Information

Approved Symbol	DNMT3B
Approved Name	DNA (cytosine-5-)-methyltransferase 3 beta
Location	20q11.2
Position	chr20:31350191-31397162 (+)
External Links	Entrez Gene: 1789 Ensembl: ENSG00000088305 UCSC: uc002wyc.3 HGNC ID: 2979
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between DNMT3B and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
DNMT3B	Higuchi, 2011	patients only		We found that the levels of DNMT1 mRNA were significantly de...... We found that the levels of DNMT1 mRNA were significantly decreased in a depressive but not in a remissive state of MDD and BPD. In addition, the levels of DNMT3B mRNA in MDD were significantly increased in a depressive but not in a remissive state. More...

Positive relationships between DNMT3B and other components at different levels (count: 0)

Positive relationship network of DNMT3B in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between DNMT3B and MDD (count: 0)

Negative relationships between DNMT3B and other components at different levels (count: 0)

DNMT3B related SNPs in MK4MDD (count: 0)

DNMT3B related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
DNA (cytosine-5)-methyltransferase 3B	Q9UBC3	0(0/0)	Gene mapped

DNMT3B related GO terms (count: 19)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0009008	DNA-methyltransferase activity	molecular function	NAS[11102980]

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005730	nucleolus	cellular component	IDA
GO:0003677	DNA binding	molecular function	IEA
GO:0010628	positive regulation of gene expression	biological process	IMP[18413740]
GO:0071230	cellular response to amino acid stimulus	biological process	IEA
GO:0031503	protein complex localization	biological process	IEA
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	IDA[17303076]
GO:0043231	intracellular membrane-bounded organelle	cellular component	IDA
GO:0051571	positive regulation of histone H3-K4 methylation	biological process	IMP[18413740]
GO:0051573	negative regulation of histone H3-K9 methylation	biological process	IMP[18413740]
GO:0046872	metal ion binding	molecular function	IEA
GO:0003714	transcription corepressor activity	molecular function	IDA[17303076]; IMP[18567530]
GO:0006349	regulation of gene expression by genetic imprinting	biological process	IEA
GO:0006346	methylation-dependent chromatin silencing	biological process	IEA
GO:0005720	nuclear heterochromatin	cellular component	IEA
GO:0005634	nucleus	cellular component	IDA
GO:0006306	DNA methylation	biological process	NAS[10555141]; TAS[10433969]
GO:0005515	protein binding	molecular function	IPI
GO:0003886	DNA (cytosine-5-)-methyltransferase activity	molecular function	IDA[16543361]; NAS[10647011]; TAS[10433969]

DNMT3B related KEGG pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa00270	cysteine and_methionine_metabolism	Cysteine and methionine metabolism	Cysteine and methionine are sulfur-containing amino acids. C...... Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway. More...

DNMT3B related BioCarta pathways (count: 0)

DNMT3B related Reactome pathways (count: 0)

DNMT3B related interactors from protein-protein interaction data in HPRD (count: 16)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
DNMT3B	SUMO1	No	in vivo;yeast 2-hybrid	11735126
DNMT3B	ZNF238	No	in vitro	11350943
DNMT3B	DNMT3A	No	in vitro;in vivo	12145218
DNMT3B	HDAC1	No	in vitro;in vivo	12202768
DNMT3B	SUV39H1	No	in vitro;in vivo	15120635
DNMT3B	SPI1	No	in vitro	16331260
DNMT3B	EED	No	in vitro	16357870
DNMT3B	UBE2I	No	in vitro;in vivo;yeast 2-hybrid	11735126
DNMT3B	DNMT3L	No	in vitro;in vivo;yeast 2-hybrid	11934864 , 12777184
DNMT3B	DNMT1	Yes	in vitro;in vivo	12145218
DNMT3B	HDAC2	Yes	in vitro;in vivo	15120635
DNMT3B	CBX5	No	in vivo	12867029
DNMT3B	NCAPG	No	in vitro;in vivo	15148359
DNMT3B	EZH2	No	in vitro	16357870
DNMT3B	CBX1	No	in vivo	12867029
DNMT3B	SMARCA5	No	in vitro;in vivo	15120635

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways