Gene Report

Basic Information

Approved Symbol	DNMT1
Approved Name	DNA (cytosine-5-)-methyltransferase 1
Previous Symbol	DNMT
Symbol Alias	MCMT, CXXC9
Location	19p13.2
Position	chr19:10244022-10305755 (-)
External Links	Entrez Gene: 1786 Ensembl: ENSG00000130816 UCSC: uc010xlc.2 HGNC ID: 2976
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between DNMT1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
DNMT1	Higuchi, 2011	patients only		We found that the levels of DNMT1 mRNA were significantly de...... We found that the levels of DNMT1 mRNA were significantly decreased in a depressive but not in a remissive state of MDD and BPD. In addition, the levels of DNMT3B mRNA in MDD were significantly increased in a depressive but not in a remissive state. More...

Positive relationships between DNMT1 and other components at different levels (count: 0)

Positive relationship network of DNMT1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between DNMT1 and MDD (count: 0)

Negative relationships between DNMT1 and other components at different levels (count: 0)

DNMT1 related SNPs in MK4MDD (count: 0)

DNMT1 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
DNA (cytosine-5)-methyltransferase 1	P26358	0(0/0)	Gene mapped

DNMT1 related GO terms (count: 22)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0009008	DNA-methyltransferase activity	molecular function	IDA[18754681]

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0016458	gene silencing	biological process	IEA
GO:0005721	centromeric heterochromatin	cellular component	IEA
GO:0003723	RNA binding	molecular function	IEA
GO:0003886	DNA (cytosine-5-)-methyltransferase activity	molecular function	IDA
GO:0010216	maintenance of DNA methylation	biological process	IDA
GO:0005657	replication fork	cellular component	IEA
GO:0016568	chromatin modification	biological process	IEA
GO:0005515	protein binding	molecular function	IPI
GO:0003677	DNA binding	molecular function	IDA[18754681]
GO:0010628	positive regulation of gene expression	biological process	IMP[18413740]
GO:0008327	methyl-CpG binding	molecular function	IEA
GO:0005634	nucleus	cellular component	IEA
GO:0051571	positive regulation of histone H3-K4 methylation	biological process	IMP[18413740]
GO:0042127	regulation of cell proliferation	biological process	IEA
GO:0006351	transcription, DNA-dependent	biological process	IEA
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	TAS[10888872]
GO:0008270	zinc ion binding	molecular function	IEA
GO:0008134	transcription factor binding	molecular function	IEA
GO:0071230	cellular response to amino acid stimulus	biological process	IEA
GO:0006306	DNA methylation	biological process	TAS[10888872]
GO:0051573	negative regulation of histone H3-K9 methylation	biological process	IMP[18413740]

DNMT1 related KEGG pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa00270	cysteine and_methionine_metabolism	Cysteine and methionine metabolism	Cysteine and methionine are sulfur-containing amino acids. C...... Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway. More...

DNMT1 related BioCarta pathways (count: 0)

DNMT1 related Reactome pathways (count: 0)

DNMT1 related interactors from protein-protein interaction data in HPRD (count: 17)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
DNMT1	PCNA	No	in vitro	9302295 , 12354094
DNMT1	EED	No	in vitro	16357870
DNMT1	DNMT1	Yes	in vitro;in vivo	10888886
DNMT1	TRIM27	No	yeast 2-hybrid	16169070
DNMT1	EZH2	No	in vitro	16357870
DNMT1	DMAP1	No	in vitro;in vivo;yeast 2-hybrid	10888872
DNMT1	RB1	No	in vitro;in vivo	10888886 , 11847125
DNMT1	SUV39H1	No	in vitro;in vivo	12711675
DNMT1	HDAC1	No	in vitro;in vivo	10615135
DNMT1	TSG101	No	in vivo;yeast 2-hybrid	10888872
DNMT1	CBX1	No	in vitro;in vivo	12711675
DNMT1	DYNLL1	No	in vitro	14760703
DNMT1	DNMT3B	Yes	in vitro;in vivo	12145218
DNMT1	HMGB1	No	in vitro	11748221
DNMT1	HDAC2	Yes	in vitro;in vivo;yeast 2-hybrid	10888872
DNMT1	DNMT3A	No	in vitro;in vivo	12145218
DNMT1	DAXX	No	in vivo	10444590

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways