Gene Report

Basic Information

Approved Symbol	CALB1
Approved Name	calbindin 1, 28kDa
Previous Symbol	CALB
Location	8q21.3
Position	chr8:91094926-91095107 (-)
External Links	Entrez Gene: 793 Ensembl: ENSG00000104327 UCSC: uc003yel.1 HGNC ID: 1434
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin; Protein mapped

Positive relationships between CALB1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
CALB1	Sibille E, 2009	animal model; patients and nomal controls	R=0.88, P-value<5E-6; y slope=1.09	Upregulated in MDD patients Upregulated in MDD patients

Positive relationships between CALB1 and other components at different levels (count: 0)

Positive relationship network of CALB1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between CALB1 and MDD (count: 0)

Negative relationships between CALB1 and other components at different levels (count: 0)

CALB1 related SNPs in MK4MDD (count: 0)

CALB1 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Calbindin	P05937	2(2/0)	Literature-origin

CALB1 related GO terms (count: 23)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0048167	regulation of synaptic plasticity	biological process	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0072205	metanephric collecting duct development	biological process	IEA
GO:0005634	nucleus	cellular component	IDA[16928804]
GO:0007614	short-term memory	biological process	IMP[22796338]
GO:0035502	metanephric part of ureteric bud development	biological process	IEA
GO:0007616	long-term memory	biological process	IMP[22796338]
GO:0043195	terminal bouton	cellular component	IEA
GO:0005509	calcium ion binding	molecular function	IMP[18359862]
GO:0045202	synapse	cellular component	IBA
GO:0008270	zinc ion binding	molecular function	IMP[18359862]
GO:0005829	cytosol	cellular component	IBA
GO:0030424	axon	cellular component	IDA[22796338]; ISS
GO:0072221	metanephric distal convoluted tubule development	biological process	IEA
GO:0051480	regulation of cytosolic calcium ion concentration	biological process	IBA
GO:0005499	vitamin D binding	molecular function	IEA
GO:0043025	neuronal cell body	cellular component	IDA[22796338]
GO:0007626	locomotory behavior	biological process	IEA
GO:0010842	retina layer formation	biological process	IEA
GO:0070062	extracellular exosome	cellular component	IDA[19056867\|23376485]
GO:0071310	cellular response to organic substance	biological process	IEA
GO:0072286	metanephric connecting tubule development	biological process	IEA
GO:0005515	protein binding	molecular function	IPI[16763551\|20098747]
GO:0030425	dendrite	cellular component	IDA[22796338]

CALB1 related KEGG pathways (count: 0)

CALB1 related BioCarta pathways (count: 0)

CALB1 related Reactome pathways (count: 0)

CALB1 related interactors from protein-protein interaction data in HPRD (count: 4)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
CALB1	TRPV6	No	in vitro	16763551
CALB1	IMPA1	No	in vitro	12176979
CALB1	TRPV5	No	in vitro;in vivo	16763551
CALB1	RANBP9	No	in vitro;in vivo;yeast 2-hybrid	12684061

Gene Report

Literature-origin GO terms

Gene mapped GO terms