MK4MDD

Gene Report

Basic Information
Approved Symbol CRHBP
Approved Name corticotropin releasing hormone binding protein
Previous Name "corticotropin releasing hormone-binding protein"
Symbol Alias CRF-BP, CRFBP
Location 5q
Position chr5:76264711-76265299 (+)
External Links Entrez Gene: 1393
Ensembl: ENSG00000145708
UCSC: uc003ker.3
HGNC ID: 2356
No. of Studies (Positive/Negative) 2(1/1) Help
Type Literature-origin; Protein mapped

Positive relationships between CRHBP and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description Help
corticotropin releasing hormone binding protein Claes, 2003 patients and normal controls P-value<0.05 Two single nucleotide polymorphisms within the corticotropin...... Two single nucleotide polymorphisms within the corticotropin releasing hormone binding protein gene were significantly associated with the disease (p <.05). An expectation-maximization algorithm estimated a specific haplotype to have a frequency of 53% in patients and 35% in controls (p <.001). More...

Positive relationships between CRHBP and other components at different levels (count: 0) Help
Positive relationship network of CRHBP in MK4MDD
Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between CRHBP and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description
CRF-BP Van Den Eede F, 2007 Patients and nomal controls In the extended Swedish population, there was a trend toward...... In the extended Swedish population, there was a trend towards an association between two SNPs and MDD. The subsequent gender analysis showed significant associations of three SNPs (CRF-BPs2 T; CRF-BPs11 T and CRF-BPs12 C) and haplotype G_T_C_T_C with MDD in Swedish males. However, these findings did not withstand correction for multiple testing and there were no significant SNP or haplotype associations in the Belgian MDD sample. In conclusion, this study does not provide confirmatory evidence for a role of the CRF-BP gene in the vulnerability for MDD in general More...

Negative relationships between CRHBP and other components at different levels (count: 0) Help
CRHBP related SNPs in MK4MDD (count: 0)
CRHBP related proteins in MK4MDD (count: 1)
CRHBP related GO terms (count: 41)
CRHBP related KEGG pathways (count: 0)
CRHBP related BioCarta pathways (count: 0)
CRHBP related Reactome pathways (count: 0)
CRHBP related interactors from protein-protein interaction data in HPRD (count: 1)