Gene Report

Basic Information

Approved Symbol	CRHBP
Approved Name	corticotropin releasing hormone binding protein
Previous Name	corticotropin releasing hormone-binding protein
Symbol Alias	CRF-BP, CRFBP
Location	5q
Position	chr5:76248680-76265299 (+)
External Links	Entrez Gene: 1393 Ensembl: ENSG00000145708 UCSC: uc003ker.3 HGNC ID: 2356
No. of Studies (Positive/Negative)	2(1/1)
Type	Literature-origin; SNP mapped; Protein mapped

Positive relationships between CRHBP and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
corticotropin releasing hormone binding protein	Claes, 2003	patients and normal controls	P-value<0.05	Two single nucleotide polymorphisms within the corticotropin...... Two single nucleotide polymorphisms within the corticotropin releasing hormone binding protein gene were significantly associated with the disease (p <.05). An expectation-maximization algorithm estimated a specific haplotype to have a frequency of 53% in patients and 35% in controls (p <.001). More...

Positive relationships between CRHBP and other components at different levels (count: 0)

Positive relationship network of CRHBP in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between CRHBP and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
CRF-BP	Van Den Eede F, 2007	Patients and nomal controls		In the extended Swedish population, there was a trend toward...... In the extended Swedish population, there was a trend towards an association between two SNPs and MDD. The subsequent gender analysis showed significant associations of three SNPs (CRF-BPs2 T; CRF-BPs11 T and CRF-BPs12 C) and haplotype G_T_C_T_C with MDD in Swedish males. However, these findings did not withstand correction for multiple testing and there were no significant SNP or haplotype associations in the Belgian MDD sample. In conclusion, this study does not provide confirmatory evidence for a role of the CRF-BP gene in the vulnerability for MDD in general More...

Negative relationships between CRHBP and other components at different levels (count: 0)

CRHBP related SNPs in MK4MDD (count: 3)

#rs	Location	Annotation	No. of Studies (Positive/Negative)
rs7728378	chr5:76259350(Forward)	downstream_gene_variant; intron_variant; nc_transcript_variant	1(1/0)
rs1875999	chr5:76264982(Forward)	3_prime_UTR_variant; downstream_gene_variant; intron_variant; nc_transcript_variant	1(1/0)
rs7718461	chr5:76258048(Forward)	downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	1(1/0)

CRHBP related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Corticotropin-releasing factor-binding protein	P24387	1(1/0)	Literature-origin

CRHBP related GO terms (count: 43)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0006954	inflammatory response	biological process	IDA[18559919]
GO:0001963	synaptic transmission, dopaminergic	biological process	ISS
GO:0051424	corticotropin-releasing hormone binding	molecular function	IDA[1846945]; IPI[18234674]

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0043204	perikaryon	cellular component	ISS
GO:0005771	multivesicular body	cellular component	ISS
GO:0005767	secondary lysosome	cellular component	ISS
GO:0071320	cellular response to cAMP	biological process	ISS
GO:0097211	cellular response to gonadotropin-releasing hormone	biological process	ISS
GO:0051459	regulation of corticotropin secretion	biological process	IDA[13150566]
GO:0031045	dense core granule	cellular component	ISS
GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity	biological process	ISS
GO:0050795	regulation of behavior	biological process	IMP[17728670]
GO:0071392	cellular response to estradiol stimulus	biological process	IDA[15345745]
GO:0030425	dendrite	cellular component	ISS
GO:0033554	cellular response to stress	biological process	IMP
GO:0071391	cellular response to estrogen stimulus	biological process	IDA[15345745]
GO:0005622	intracellular	cellular component	ISS
GO:0007611	learning or memory	biological process	TAS[7477348]
GO:0071356	cellular response to tumor necrosis factor	biological process	IDA[15345745]
GO:0005515	protein binding	molecular function	IPI[18234674]
GO:0009755	hormone-mediated signaling pathway	biological process	IDA[18234674]
GO:0005794	Golgi apparatus	cellular component	IDA
GO:0071314	cellular response to cocaine	biological process	ISS
GO:0005615	extracellular space	cellular component	IDA[1846945]
GO:0005783	endoplasmic reticulum	cellular component	IDA
GO:0048149	behavioral response to ethanol	biological process	IMP
GO:0043679	axon terminus	cellular component	ISS
GO:0035865	cellular response to potassium ion	biological process	IDA
GO:0030141	secretory granule	cellular component	IDA
GO:0051460	negative regulation of corticotropin secretion	biological process	IDA[1846945]
GO:1900011	negative regulation of corticotropin-releasing hormone receptor activity	biological process	IDA[18234674]
GO:0002125	maternal aggressive behavior	biological process	ISS
GO:0007165	signal transduction	biological process	TAS[7477348]
GO:0042277	peptide binding	molecular function	ISS
GO:0035690	cellular response to drug	biological process	ISS
GO:0005634	nucleus	cellular component	ISS
GO:0045055	regulated secretory pathway	biological process	IDA
GO:0043196	varicosity	cellular component	ISS
GO:0071277	cellular response to calcium ion	biological process	ISS
GO:0042445	hormone metabolic process	biological process	IEA
GO:0005874	microtubule	cellular component	ISS
GO:0007610	behavior	biological process	ISS
GO:0007565	female pregnancy	biological process	IDA[18559919]; IEP[1846945]

CRHBP related KEGG pathways (count: 0)

CRHBP related BioCarta pathways (count: 0)

CRHBP related Reactome pathways (count: 0)

CRHBP related interactors from protein-protein interaction data in HPRD (count: 1)

Gene Report

Literature-origin GO terms

Gene mapped GO terms