
Gene Report
Approved Symbol | APOE |
---|---|
Approved Name | apolipoprotein E |
Previous Symbol | AD2 |
Previous Name | "Alzheimer disease 2 (APOE*E4-associated, late onset)" |
Location | 19q13.31 |
Position | chr19:45412508-45412650 (+) |
External Links |
Entrez Gene: 348 Ensembl: ENSG00000130203 UCSC: uc002pab.3 HGNC ID: 613 |
No. of Studies (Positive/Negative) | 2(0/2)
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Type | Literature-origin; Protein mapped |
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus | Protein and Other Molecule | Cell and Molecular Pathway | Neural System | Cognition and Behavior | Symptoms and Signs | Environment | MDD |
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2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Name in Literature | Reference | Research Type | Statistical Result | Relation Description |
---|---|---|---|---|
APOE | Steffens DC, 2003 | nomal people | There was no overall association between APOE and depression...... There was no overall association between APOE and depression. More... | |
APOE | Surtees PG, 2009 | nomal people | No associations were found between APOE genotypes and measu...... No associations were found between APOE genotypes and measures either of past-year or lifetime MDD More... |
Approved Name | UniportKB | No. of Studies (Positive/Negative) | Source | |
---|---|---|---|---|
Apolipoprotein E | P02649 | 2(2/0) | Literature-origin |
Literature-origin GO terms | ||||
ID | Name | Type | Evidence | |
---|---|---|---|---|
GO:0016209 | antioxidant activity | molecular function | IDA[9685360] |
Gene mapped GO terms | ||||
ID | Name | Type | Evidence | |
---|---|---|---|---|
GO:1901216 | positive regulation of neuron death | biological process | IDA[24259049] | |
GO:0034374 | low-density lipoprotein particle remodeling | biological process | IEA | |
GO:0005543 | phospholipid binding | molecular function | IDA[4066713] | |
GO:0031102 | neuron projection regeneration | biological process | IBA | |
GO:0033344 | cholesterol efflux | biological process | IDA[11162594|16443932] | |
GO:0006775 | fat-soluble vitamin metabolic process | biological process | TAS | |
GO:0006695 | cholesterol biosynthetic process | biological process | IBA | |
GO:0005319 | lipid transporter activity | molecular function | IDA[17305370] | |
GO:0046889 | positive regulation of lipid biosynthetic process | biological process | IDA[12042316] | |
GO:0019934 | cGMP-mediated signaling | biological process | IDA[8995232] | |
GO:0042158 | lipoprotein biosynthetic process | biological process | IEA | |
GO:1903002 | positive regulation of lipid transport across blood brain barrier | biological process | IDA[24345162] | |
GO:0005634 | nucleus | cellular component | IDA[21630459] | |
GO:0061000 | negative regulation of dendritic spine development | biological process | IDA[24328732] | |
GO:0019068 | virion assembly | biological process | IMP[25122793] | |
GO:0034361 | very-low-density lipoprotein particle | cellular component | IDA[8245722|17154273] | |
GO:0006898 | receptor-mediated endocytosis | biological process | IDA[1917954]; TAS | |
GO:0010875 | positive regulation of cholesterol efflux | biological process | IDA[12042316|14754908]; IGI[12401887] | |
GO:1903001 | negative regulation of lipid transport across blood brain barrier | biological process | IDA[24345162] | |
GO:0007010 | cytoskeleton organization | biological process | TAS[9622609] | |
GO:1902430 | negative regulation of beta-amyloid formation | biological process | IDA[24154541|24259049] | |
GO:0070062 | extracellular exosome | cellular component | IDA[19056867|20458337|23376485|23533145] | |
GO:0051044 | positive regulation of membrane protein ectodomain proteolysis | biological process | IDA[15950758] | |
GO:0010873 | positive regulation of cholesterol esterification | biological process | IDA[15654758] | |
GO:0005886 | plasma membrane | cellular component | TAS | |
GO:0010468 | regulation of gene expression | biological process | IEA | |
GO:0006707 | cholesterol catabolic process | biological process | IBA | |
GO:0007263 | nitric oxide mediated signal transduction | biological process | IDA[8995232] | |
GO:1903561 | extracellular vesicle | cellular component | IDA[24769233] | |
GO:1902947 | regulation of tau-protein kinase activity | biological process | IDA[24154541] | |
GO:0032805 | positive regulation of low-density lipoprotein particle receptor catabolic process | biological process | IDA[15950758] | |
GO:0042311 | vasodilation | biological process | IEA | |
GO:0007186 | G-protein coupled receptor signaling pathway | biological process | IDA[16443932] | |
GO:0060999 | positive regulation of dendritic spine development | biological process | IDA[24328732] | |
GO:1901630 | negative regulation of presynaptic membrane organization | biological process | IDA[24259049] | |
GO:0051000 | positive regulation of nitric-oxide synthase activity | biological process | IDA[8995232] | |
GO:0043407 | negative regulation of MAP kinase activity | biological process | IDA[9685360] | |
GO:0072562 | blood microparticle | cellular component | IDA[22516433] | |
GO:0005515 | protein binding | molecular function | IPI[7566652|7972031|8245722|12950167|19758344|21163940|21593558|24447298|25122793] | |
GO:0097114 | NMDA glutamate receptor clustering | biological process | IDA[24328732] | |
GO:0090370 | negative regulation of cholesterol efflux | biological process | IDA[12042316] | |
GO:0042802 | identical protein binding | molecular function | IDA[4066713] | |
GO:0043025 | neuronal cell body | cellular component | NAS[8083695] | |
GO:0031012 | extracellular matrix | cellular component | IDA[23658023] | |
GO:0030828 | positive regulation of cGMP biosynthetic process | biological process | IDA[8995232] | |
GO:1902004 | positive regulation of beta-amyloid formation | biological process | IDA[24154541|24259049] | |
GO:0071682 | endocytic vesicle lumen | cellular component | TAS | |
GO:1902952 | positive regulation of dendritic spine maintenance | biological process | IDA[24328732] | |
GO:1901215 | negative regulation of neuron death | biological process | IDA[24259049] | |
GO:0034375 | high-density lipoprotein particle remodeling | biological process | IGI[12401887] | |
GO:0034363 | intermediate-density lipoprotein particle | cellular component | IDA[17336988] | |
GO:0017127 | cholesterol transporter activity | molecular function | IBA | |
GO:0010544 | negative regulation of platelet activation | biological process | IDA[8995232] | |
GO:0005576 | extracellular region | cellular component | TAS | |
GO:0001523 | retinoid metabolic process | biological process | TAS | |
GO:0033700 | phospholipid efflux | biological process | IDA[11162594] | |
GO:0008203 | cholesterol metabolic process | biological process | IDA[9649566]; IMP[3771793] | |
GO:0043524 | negative regulation of neuron apoptotic process | biological process | IBA | |
GO:1902995 | positive regulation of phospholipid efflux | biological process | IDA[12042316] | |
GO:0017038 | protein import | biological process | IDA[24446231] | |
GO:1901628 | positive regulation of postsynaptic membrane organization | biological process | IDA[24259049] | |
GO:0034382 | chylomicron remnant clearance | biological process | IMP[7175379] | |
GO:1902999 | negative regulation of phospholipid efflux | biological process | IDA[12042316] | |
GO:1900221 | regulation of beta-amyloid clearance | biological process | IDA[24446231] | |
GO:0090090 | negative regulation of canonical Wnt signaling pathway | biological process | TAS[22988876] | |
GO:0034362 | low-density lipoprotein particle | cellular component | IDA[8245722] | |
GO:0070326 | very-low-density lipoprotein particle receptor binding | molecular function | IDA[1384047]; IPI[12950167] | |
GO:0000302 | response to reactive oxygen species | biological process | NAS[11743999] | |
GO:0048156 | tau protein binding | molecular function | IPI[7566652] | |
GO:0005794 | Golgi apparatus | cellular component | IDA[25122793] | |
GO:0005783 | endoplasmic reticulum | cellular component | IDA[25122793] | |
GO:1902951 | negative regulation of dendritic spine maintenance | biological process | IDA[24328732] | |
GO:0032489 | regulation of Cdc42 protein signal transduction | biological process | IDA[16443932] | |
GO:0042632 | cholesterol homeostasis | biological process | IDA[9649566] | |
GO:0097113 | AMPA glutamate receptor clustering | biological process | IDA[24328732] | |
GO:0006641 | triglyceride metabolic process | biological process | IDA[9649566]; IMP[3771793] | |
GO:0048168 | regulation of neuronal synaptic plasticity | biological process | TAS[9622609] | |
GO:0043537 | negative regulation of blood vessel endothelial cell migration | biological process | IDA[9685360] | |
GO:0046907 | intracellular transport | biological process | TAS[9622609] | |
GO:0048844 | artery morphogenesis | biological process | IEA | |
GO:0034364 | high-density lipoprotein particle | cellular component | IDA[210174] | |
GO:0030195 | negative regulation of blood coagulation | biological process | IDA[8995232] | |
GO:0019433 | triglyceride catabolic process | biological process | IBA | |
GO:0051055 | negative regulation of lipid biosynthetic process | biological process | IDA[12042316] | |
GO:0001937 | negative regulation of endothelial cell proliferation | biological process | IDA[9685360] | |
GO:0007271 | synaptic transmission, cholinergic | biological process | TAS[9622609] | |
GO:1901214 | regulation of neuron death | biological process | IDA[24154541] | |
GO:0034447 | very-low-density lipoprotein particle clearance | biological process | IDA[1917954]; IMP[9649566] | |
GO:0015485 | cholesterol binding | molecular function | IBA | |
GO:0002021 | response to dietary excess | biological process | IEA | |
GO:0050750 | low-density lipoprotein particle receptor binding | molecular function | IDA[210175]; IPI[17326667] | |
GO:0043691 | reverse cholesterol transport | biological process | IDA[8127890] | |
GO:0015909 | long-chain fatty acid transport | biological process | IDA[24345162] | |
GO:0030425 | dendrite | cellular component | NAS[8083695] | |
GO:0005737 | cytoplasm | cellular component | NAS[8083695]; TAS[9622609] | |
GO:0050728 | negative regulation of inflammatory response | biological process | IC[8995232] | |
GO:0006766 | vitamin metabolic process | biological process | TAS | |
GO:0008289 | lipid binding | molecular function | IDA[4066713] | |
GO:0044281 | small molecule metabolic process | biological process | TAS | |
GO:0034380 | high-density lipoprotein particle assembly | biological process | IDA[17305370] | |
GO:1901627 | negative regulation of postsynaptic membrane organization | biological process | IDA[24259049] | |
GO:0055089 | fatty acid homeostasis | biological process | IDA[24345162] | |
GO:0042159 | lipoprotein catabolic process | biological process | IBA | |
GO:0042627 | chylomicron | cellular component | IDA[8245722|16935699] | |
GO:0051651 | maintenance of location in cell | biological process | IEA | |
GO:0006874 | cellular calcium ion homeostasis | biological process | IEA | |
GO:0005769 | early endosome | cellular component | TAS | |
GO:0046911 | metal chelating activity | molecular function | IDA[9685360] | |
GO:0016020 | membrane | cellular component | IDA[19946888] | |
GO:0098869 | cellular oxidant detoxification | biological process | IDA[9685360] | |
GO:0042157 | lipoprotein metabolic process | biological process | TAS | |
GO:0030516 | regulation of axon extension | biological process | TAS[9622609] | |
GO:0044794 | positive regulation by host of viral process | biological process | IMP[25122793] | |
GO:1902998 | positive regulation of neurofibrillary tangle assembly | biological process | IDA[24154541] | |
GO:1901631 | positive regulation of presynaptic membrane organization | biological process | IDA[24259049] | |
GO:0071813 | lipoprotein particle binding | molecular function | IEA | |
GO:0045541 | negative regulation of cholesterol biosynthetic process | biological process | IDA[1917954] | |
GO:0005615 | extracellular space | cellular component | IDA[16502470|20551380] | |
GO:0008201 | heparin binding | molecular function | IDA[2745454] | |
GO:0042803 | protein homodimerization activity | molecular function | IPI[8245722] | |
GO:0007603 | phototransduction, visible light | biological process | TAS | |
GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity | molecular function | IDA[15654758] | |
GO:0034372 | very-low-density lipoprotein particle remodeling | biological process | IDA[15654758]; IGI[12401887] | |
GO:0001540 | beta-amyloid binding | molecular function | IDA[11305869] | |
GO:0034384 | high-density lipoprotein particle clearance | biological process | IDA[210175] |
Gene mapped KEGG pathways | ||||
ID | Name | Brief Description | Full Description | |
---|---|---|---|---|
hsa05010 | alzheimers disease | Alzheimer's disease | Alzheimer's disease (AD) is a chronic disorder that slowly d...... Alzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. The extracellular Abeta oligomers may activate caspases through activation of cell surface death receptors. Alternatively, intracellular Abeta may contribute to pathology by facilitating tau hyper-phosphorylation, disrupting mitochondria function, and triggering calcium dysfunction. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specifically the more amyloidogenic form, Abeta42. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress. More... |
Gene mapped Reactome pathways | |||
ID | Name | Description | |
---|---|---|---|
REACT_602 | metabolism of_lipids_and_lipoproteins | Lipids are hydrophobic but otherwise chemically diverse mole...... Lipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphingolipids, eicosanoids, cholesterol, bile salts, steroid hormones, and fat-soluble vitamins, and function as a major source of energy (fatty acids, triacylglycerols, and ketone bodies), are major constituents of cell membranes (cholesterol and phospholipids), play a major role in their own digestion and uptake (bile salts), and participate in numerous signaling and regulatory processes (steroid hormones, eicosanoids, and sphingolipids). Because of their poor solubility in water, most lipids in extracellular spaces in the human body are found as complexes with specific carrier proteins. Regulation of the formation and movement of these lipoprotein complexes is a critical aspect of human lipid metabolism, and lipoprotein abnormalities are associated with major human disease processes including atherosclerosis and diabetes. Aspects of lipid metabolism currently annotated in Reactome include lipid digestion, trafficking of dietary sterols, triacylglycerol synthesis (fatty acid synthesis and triacylglycerol assembly), hormone-sensitive lipase-mediated triacylglycerol breakdown, and beta-oxidation of fatty acids, ketone body metabolism (synthesis and utilization), the synthesis of cholesterol, bile salts, and steroid hormones, and sphingolipid metabolism. Three aspects of lipoprotein function are currently annotated: chylomicron-mediated lipid transport, HDL (high density lipoprotein)-mediated lipid transport, and LDL (low density lipoprotein) endocytosis and degradation. More... | |
REACT_6841 | chylomicron mediated_lipid_transport | Chylomicrons transport triacylglycerol, phospholipid, and ch...... Chylomicrons transport triacylglycerol, phospholipid, and cholesterol derived from dietary lipid from the small intestine to other tissues of the body. Each chylomicron assembles around a single molecule of apolipoprotein B-48 which at the time the particle leaves the intestine and enters the lymphatic circulation is complexed with >200,000 molecules of triacylglycerol. As chylomicrons circulate in the body, they acquire molecules of apolipoproteins C and E, and through interaction with endothelial lipases can lose a large fraction of their triacylglycerol. These changes convert them to chylomicron remnants which bind to LDL receptors, primarily on the surfaces of liver cells, clearing them from the circulation. This whole sequence of events is rapid: the normal lifespan of a chylomicron is 30 - 60 minutes. More... | |
REACT_6823 | lipoprotein metabolism | Because of their hydrophobicity, lipids are found in the ext...... Because of their hydrophobicity, lipids are found in the extracellular spaces of the human body primarily in the form of lipoprotein complexes. Chylomicrons form in the small intestine and transport dietary lipids to other tissues in the body. Very low density lipoproteins (VLDL) form in the liver and transport triacylglycerol synthesized there to other tissues of the body. As they circulate, VLDL are acted on by lipoprotein lipases on the endothelial surfaces of blood vessels, liberating fatty acids and glycerol to be taken up by tissues and converting the VLDL first to intermediate density lipoproteins (IDL) and then to low density lipoproteins (LDL). IDL and LDL are cleared from the circulation via a specific cell surface receptor, found in the body primarily on the surfaces of liver cells. High density lipoprotein (HDL) particles, initially formed primarily by the liver, shuttle several kinds of lipids between tissues and other lipoproteins. Notably, they are responsible for the so-called reverse transport of cholesterol from peripheral tissues to LDL for return to the liver. Three aspects of lipoprotein function are currently annotated in Reactome: chylomicron-mediated lipid transport, LDL endocytosis and degradation, and HDL-mediated lipid transport. More... |

Gene | Interactor | Interactor in MK4MDD? | Experiment Type | PMID | |
---|---|---|---|---|---|
APOE | SCARB1 | No | in vitro;in vivo | 12138091 | |
APOE | LRP8 | Yes | in vivo | 12167620 , 12950167 | |
APOE | MAP2 | No | in vitro | 8624078 | |
APOE | ALB | No | in vitro | 8063017 | |
APOE | CTSB | Yes | in vivo | 12057992 | |
APOE | LRP1 | No | in vivo | 11421580 | |
APOE | CNTF | No | in vitro | 9236223 | |
APOE | MAPT | No | in vitro;in vivo | 9147408 , 7566652 , 9512010 | |
APOE | VLDLR | No | in vivo | 12167620 | |
APOE | PLTP | No | in vitro;in vivo | 12810820 | |
APOE | PRNP | No | in vivo | 15146195 | |
APOE | LRP2 | No | in vivo | 11421580 | |
APOE | APP | No | in vitro | 10559559 | |
APOE | APOE | Yes | in vitro | 9147408 , 7566652 | |
APOE | NEFM | No | in vitro | 8620924 | |
APOE | LDLR | No | in vitro;in vivo | 12036962 | |
APOE | A2M | No | in vitro;in vivo | 9831625 |