
Gene Report
Approved Symbol | APOE |
---|---|
Approved Name | apolipoprotein E |
Previous Symbol | AD2 |
Previous Name | Alzheimer disease 2 (APOE*E4-associated, late onset) |
Location | 19q13.31 |
Position | chr19:45409039-45412650 (+) |
External Links |
Entrez Gene: 348 Ensembl: ENSG00000130203 UCSC: uc002pab.3 HGNC ID: 613 |
No. of Studies (Positive/Negative) | 2(0/2)
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Type | Literature-origin; Protein mapped |
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus | Protein and Other Molecule | Cell and Molecular Pathway | Neural System | Cognition and Behavior | Symptoms and Signs | Environment | MDD |
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2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Name in Literature | Reference | Research Type | Statistical Result | Relation Description |
---|---|---|---|---|
APOE | Steffens DC, 2003 | nomal people | There was no overall association between APOE and depression...... There was no overall association between APOE and depression. More... | |
APOE | Surtees PG, 2009 | nomal people | No associations were found between APOE genotypes and measu...... No associations were found between APOE genotypes and measures either of past-year or lifetime MDD More... |
Approved Name | UniportKB | No. of Studies (Positive/Negative) | Source | |
---|---|---|---|---|
Apolipoprotein E | P02649 | 2(2/0) | Literature-origin |
Literature-origin GO terms | ||||
ID | Name | Type | Evidence | |
---|---|---|---|---|
GO:0016209 | antioxidant activity | molecular function | IDA[9685360] |
Gene mapped GO terms | ||||
ID | Name | Type | Evidence | |
---|---|---|---|---|
GO:0034447 | very-low-density lipoprotein particle clearance | biological process | IDA[1917954]; IMP[9649566] | |
GO:0042159 | lipoprotein catabolic process | biological process | IEA | |
GO:0006874 | cellular calcium ion homeostasis | biological process | IEA | |
GO:0046982 | protein heterodimerization activity | molecular function | IPI[8245722] | |
GO:0043691 | reverse cholesterol transport | biological process | IDA[8127890] | |
GO:0006707 | cholesterol catabolic process | biological process | IEA | |
GO:0045471 | response to ethanol | biological process | IEA | |
GO:0030195 | negative regulation of blood coagulation | biological process | IDA[8995232] | |
GO:0042632 | cholesterol homeostasis | biological process | IDA[9649566] | |
GO:0019934 | cGMP-mediated signaling | biological process | IDA[8995232] | |
GO:0034372 | very-low-density lipoprotein particle remodeling | biological process | IDA[15654758]; IGI[12401887] | |
GO:0017127 | cholesterol transporter activity | molecular function | IEA | |
GO:0010873 | positive regulation of cholesterol esterification | biological process | IDA[15654758] | |
GO:0007263 | nitric oxide mediated signal transduction | biological process | IDA[8995232] | |
GO:0051044 | positive regulation of membrane protein ectodomain proteolysis | biological process | IDA[15950758] | |
GO:0044281 | small molecule metabolic process | biological process | TAS | |
GO:0007010 | cytoskeleton organization | biological process | TAS[9622609] | |
GO:0031232 | extrinsic to external side of plasma membrane | cellular component | IEA | |
GO:0008201 | heparin binding | molecular function | IDA[2745454] | |
GO:0006629 | lipid metabolic process | biological process | TAS | |
GO:0033700 | phospholipid efflux | biological process | IDA[11162594] | |
GO:0046848 | hydroxyapatite binding | molecular function | IEA | |
GO:0050750 | low-density lipoprotein particle receptor binding | molecular function | IDA[210175]; IPI[17326667] | |
GO:0005737 | cytoplasm | cellular component | NAS[8083695]; TAS[9622609] | |
GO:0032805 | positive regulation of low-density lipoprotein particle receptor catabolic process | biological process | IDA[15950758] | |
GO:0048844 | artery morphogenesis | biological process | IEA | |
GO:0005886 | plasma membrane | cellular component | TAS | |
GO:0045773 | positive regulation of axon extension | biological process | IEA | |
GO:0046907 | intracellular transport | biological process | TAS[9622609] | |
GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity | molecular function | IDA[15654758] | |
GO:0071347 | cellular response to interleukin-1 | biological process | IEA | |
GO:0032489 | regulation of Cdc42 protein signal transduction | biological process | IDA[16443932] | |
GO:0005515 | protein binding | molecular function | IPI | |
GO:0032868 | response to insulin stimulus | biological process | IEA | |
GO:0042803 | protein homodimerization activity | molecular function | IDA[8245722] | |
GO:0042802 | identical protein binding | molecular function | IDA[4066713] | |
GO:0032526 | response to retinoic acid | biological process | IEA | |
GO:0005794 | Golgi apparatus | cellular component | IEA | |
GO:0043407 | negative regulation of MAP kinase activity | biological process | IDA[9685360] | |
GO:0043066 | negative regulation of apoptotic process | biological process | IDA[9685360] | |
GO:0030828 | positive regulation of cGMP biosynthetic process | biological process | IDA[8995232] | |
GO:0034361 | very-low-density lipoprotein particle | cellular component | IDA[17154273] | |
GO:0014012 | peripheral nervous system axon regeneration | biological process | IEA | |
GO:0005576 | extracellular region | cellular component | TAS | |
GO:0001540 | beta-amyloid binding | molecular function | IDA[11305869] | |
GO:0008289 | lipid binding | molecular function | IDA[4066713] | |
GO:0007568 | aging | biological process | IEA | |
GO:0046911 | metal chelating activity | molecular function | IDA[9685360] | |
GO:0007271 | synaptic transmission, cholinergic | biological process | TAS[9622609] | |
GO:0006641 | triglyceride metabolic process | biological process | IDA[9649566]; IMP[3771793] | |
GO:0007186 | G-protein coupled receptor signaling pathway | biological process | IDA[16443932] | |
GO:0001937 | negative regulation of endothelial cell proliferation | biological process | IDA[9685360] | |
GO:0008219 | cell death | biological process | IEA | |
GO:0050728 | negative regulation of inflammatory response | biological process | IC[8995232] | |
GO:0048709 | oligodendrocyte differentiation | biological process | IEA | |
GO:0051651 | maintenance of location in cell | biological process | IEA | |
GO:0043537 | negative regulation of blood vessel endothelial cell migration | biological process | IDA[9685360] | |
GO:0005543 | phospholipid binding | molecular function | IDA[4066713] | |
GO:0070326 | very-low-density lipoprotein particle receptor binding | molecular function | IDA[1384047]; IPI[12950167] | |
GO:0006898 | receptor-mediated endocytosis | biological process | IDA[1917954] | |
GO:0042627 | chylomicron | cellular component | IDA[16935699] | |
GO:0010468 | regulation of gene expression | biological process | IEA | |
GO:0010875 | positive regulation of cholesterol efflux | biological process | IDA[14754908]; IGI[12401887] | |
GO:0071397 | cellular response to cholesterol | biological process | IEA | |
GO:0005770 | late endosome | cellular component | IEA | |
GO:0043524 | negative regulation of neuron apoptotic process | biological process | IEA | |
GO:0010544 | negative regulation of platelet activation | biological process | IDA[8995232] | |
GO:0034363 | intermediate-density lipoprotein particle | cellular component | IDA[17336988] | |
GO:0042311 | vasodilation | biological process | IEA | |
GO:0034362 | low-density lipoprotein particle | cellular component | IDA[8245722] | |
GO:0034380 | high-density lipoprotein particle assembly | biological process | IDA[17305370] | |
GO:0034384 | high-density lipoprotein particle clearance | biological process | IDA[210175] | |
GO:0000302 | response to reactive oxygen species | biological process | NAS[11743999] | |
GO:0008203 | cholesterol metabolic process | biological process | IDA[9649566]; IMP[3771793] | |
GO:0006917 | induction of apoptosis | biological process | IDA[12753088] | |
GO:0005615 | extracellular space | cellular component | IDA | |
GO:0048168 | regulation of neuronal synaptic plasticity | biological process | TAS[9622609] | |
GO:0030425 | dendrite | cellular component | NAS[8083695] | |
GO:0048156 | tau protein binding | molecular function | IPI[7566652] | |
GO:0045541 | negative regulation of cholesterol biosynthetic process | biological process | IDA[1917954] | |
GO:0071813 | lipoprotein particle binding | molecular function | IEA | |
GO:0034374 | low-density lipoprotein particle remodeling | biological process | IEA | |
GO:0071363 | cellular response to growth factor stimulus | biological process | IEA | |
GO:0034364 | high-density lipoprotein particle | cellular component | IDA[210174] | |
GO:0042158 | lipoprotein biosynthetic process | biological process | IEA | |
GO:0043025 | neuronal cell body | cellular component | NAS[8083695] | |
GO:0002021 | response to dietary excess | biological process | IEA | |
GO:0030516 | regulation of axon extension | biological process | TAS[9622609] | |
GO:0051000 | positive regulation of nitric-oxide synthase activity | biological process | IDA[8995232] | |
GO:0034375 | high-density lipoprotein particle remodeling | biological process | IGI[12401887] | |
GO:0005319 | lipid transporter activity | molecular function | IDA[17305370] | |
GO:0033344 | cholesterol efflux | biological process | IDA[11162594] | |
GO:0034382 | chylomicron remnant clearance | biological process | IMP[7175379] | |
GO:0042157 | lipoprotein metabolic process | biological process | TAS |
Gene mapped KEGG pathways | ||||
ID | Name | Brief Description | Full Description | |
---|---|---|---|---|
hsa05010 | alzheimers disease | Alzheimer's disease | Alzheimer's disease (AD) is a chronic disorder that slowly d...... Alzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. The extracellular Abeta oligomers may activate caspases through activation of cell surface death receptors. Alternatively, intracellular Abeta may contribute to pathology by facilitating tau hyper-phosphorylation, disrupting mitochondria function, and triggering calcium dysfunction. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specifically the more amyloidogenic form, Abeta42. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress. More... |
Gene mapped Reactome pathways | |||
ID | Name | Description | |
---|---|---|---|
REACT_6841 | chylomicron mediated_lipid_transport | Chylomicrons transport triacylglycerol, phospholipid, and ch...... Chylomicrons transport triacylglycerol, phospholipid, and cholesterol derived from dietary lipid from the small intestine to other tissues of the body. Each chylomicron assembles around a single molecule of apolipoprotein B-48 which at the time the particle leaves the intestine and enters the lymphatic circulation is complexed with >200,000 molecules of triacylglycerol. As chylomicrons circulate in the body, they acquire molecules of apolipoproteins C and E, and through interaction with endothelial lipases can lose a large fraction of their triacylglycerol. These changes convert them to chylomicron remnants which bind to LDL receptors, primarily on the surfaces of liver cells, clearing them from the circulation. This whole sequence of events is rapid: the normal lifespan of a chylomicron is 30 - 60 minutes. More... | |
REACT_6823 | lipoprotein metabolism | Because of their hydrophobicity, lipids are found in the ext...... Because of their hydrophobicity, lipids are found in the extracellular spaces of the human body primarily in the form of lipoprotein complexes. Chylomicrons form in the small intestine and transport dietary lipids to other tissues in the body. Very low density lipoproteins (VLDL) form in the liver and transport triacylglycerol synthesized there to other tissues of the body. As they circulate, VLDL are acted on by lipoprotein lipases on the endothelial surfaces of blood vessels, liberating fatty acids and glycerol to be taken up by tissues and converting the VLDL first to intermediate density lipoproteins (IDL) and then to low density lipoproteins (LDL). IDL and LDL are cleared from the circulation via a specific cell surface receptor, found in the body primarily on the surfaces of liver cells. High density lipoprotein (HDL) particles, initially formed primarily by the liver, shuttle several kinds of lipids between tissues and other lipoproteins. Notably, they are responsible for the so-called reverse transport of cholesterol from peripheral tissues to LDL for return to the liver. Three aspects of lipoprotein function are currently annotated in Reactome: chylomicron-mediated lipid transport, LDL endocytosis and degradation, and HDL-mediated lipid transport. More... | |
REACT_602 | metabolism of_lipids_and_lipoproteins | Lipids are hydrophobic but otherwise chemically diverse mole...... Lipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphingolipids, eicosanoids, cholesterol, bile salts, steroid hormones, and fat-soluble vitamins, and function as a major source of energy (fatty acids, triacylglycerols, and ketone bodies), are major constituents of cell membranes (cholesterol and phospholipids), play a major role in their own digestion and uptake (bile salts), and participate in numerous signaling and regulatory processes (steroid hormones, eicosanoids, and sphingolipids). Because of their poor solubility in water, most lipids in extracellular spaces in the human body are found as complexes with specific carrier proteins. Regulation of the formation and movement of these lipoprotein complexes is a critical aspect of human lipid metabolism, and lipoprotein abnormalities are associated with major human disease processes including atherosclerosis and diabetes. Aspects of lipid metabolism currently annotated in Reactome include lipid digestion, trafficking of dietary sterols, triacylglycerol synthesis (fatty acid synthesis and triacylglycerol assembly), hormone-sensitive lipase-mediated triacylglycerol breakdown, and beta-oxidation of fatty acids, ketone body metabolism (synthesis and utilization), the synthesis of cholesterol, bile salts, and steroid hormones, and sphingolipid metabolism. Three aspects of lipoprotein function are currently annotated: chylomicron-mediated lipid transport, HDL (high density lipoprotein)-mediated lipid transport, and LDL (low density lipoprotein) endocytosis and degradation. More... |

Gene | Interactor | Interactor in MK4MDD? | Experiment Type | PMID | |
---|---|---|---|---|---|
APOE | LDLR | No | in vitro;in vivo | 12036962 | |
APOE | VLDLR | No | in vivo | 12167620 | |
APOE | MAP2 | No | in vitro | 8624078 | |
APOE | PRNP | No | in vivo | 15146195 | |
APOE | SCARB1 | No | in vitro;in vivo | 12138091 | |
APOE | PLTP | No | in vitro;in vivo | 12810820 | |
APOE | NEFM | No | in vitro | 8620924 | |
APOE | LRP1 | No | in vivo | 11421580 | |
APOE | CNTF | No | in vitro | 9236223 | |
APOE | APOE | Yes | in vitro | 9147408 , 7566652 | |
APOE | A2M | No | in vitro;in vivo | 9831625 | |
APOE | APP | No | in vitro | 10559559 | |
APOE | CTSB | Yes | in vivo | 12057992 | |
APOE | LRP2 | No | in vivo | 11421580 | |
APOE | ALB | No | in vitro | 8063017 | |
APOE | MAPT | No | in vitro;in vivo | 9147408 , 7566652 , 9512010 | |
APOE | LRP8 | Yes | in vivo | 12167620 , 12950167 |