Gene Report

Basic Information

Approved Symbol	USP46
Approved Name	ubiquitin specific peptidase 46
Previous Name	ubiquitin specific protease 46
Symbol Alias	FLJ12552
Location	4q12
Position	chr4:53457126-53525502 (-)
External Links	Entrez Gene: 64854 Ensembl: ENSG00000109189 UCSC: uc003gzn.3 HGNC ID: 20075
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between USP46 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
ubiquitin-specific peptidase 46	Fukuo, 2011	patients and normal controls		We detected an association between the USP46 gene and MDD in...... We detected an association between the USP46 gene and MDD in a haplotype analysis (rs2244291-rs10034164-rs346005 and rs12646800-rs2244291-rs10034164-rs346005) More...

Positive relationships between USP46 and other components at different levels (count: 0)

Positive relationship network of USP46 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between USP46 and MDD (count: 0)

Negative relationships between USP46 and other components at different levels (count: 0)

USP46 related SNPs in MK4MDD (count: 0)

USP46 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Ubiquitin carboxyl-terminal hydrolase 46	P62068	0(0/0)	Gene mapped

USP46 related GO terms (count: 7)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0004221	ubiquitin thiolesterase activity	molecular function	IDA[19075014]
GO:0005515	protein binding	molecular function	IPI[19075014]
GO:0016579	protein deubiquitination	biological process	IDA[19075014]
GO:0004843	ubiquitin-specific protease activity	molecular function	IDA[19075014]
GO:0007610	behavior	biological process	ISS
GO:0006511	ubiquitin-dependent protein catabolic process	biological process	IEA
GO:0032228	regulation of synaptic transmission, GABAergic	biological process	ISS

USP46 related KEGG pathways (count: 0)

USP46 related BioCarta pathways (count: 0)

USP46 related Reactome pathways (count: 0)

USP46 related interactors from protein-protein interaction data in HPRD (count: 0)

Gene Report

Gene mapped GO terms