Gene Report

Basic Information

Approved Symbol	KLRK1
Approved Name	killer cell lectin-like receptor subfamily K, member 1
Previous Symbol	D12S2489E
Previous Name	DNA segment on chromosome 12 (unique) 2489 expressed sequence
Symbol Alias	NKG2D, KLR, NKG2-D, CD314
Location	12p13.2-p12.3
Position	chr12:10524952-10542653 (-)
External Links	Entrez Gene: 22914 Ensembl: ENSG00000213809 UCSC: uc009zhj.3 HGNC ID: 18788
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between KLRK1 and MDD (count: 0)

Positive relationships between KLRK1 and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
Klrk1		Histone-lysine N-methyltransferase SETDB1(Setdb1 (Set domain, bifurcated 1))	protein	Jiang Y, 2010	animal model		Gene was occupied by Setdb1 in neuron Gene was occupied by Setdb1 in neuron

Positive relationship network of KLRK1 in MK4MDD

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between KLRK1 and MDD (count: 0)

Negative relationships between KLRK1 and other components at different levels (count: 0)

KLRK1 related SNPs in MK4MDD (count: 0)

KLRK1 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
NKG2-D type II integral membrane protein	P26718	0(0/0)	Gene mapped

KLRK1 related GO terms (count: 0)

KLRK1 related KEGG pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04650	natural killer_cell_mediated_cytotoxicity	Natural killer cell mediated cytotoxicity	Natural killer (NK) cells are lymphocytes of the innate immu...... Natural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stress, such as infection with viruses, bacteria, or parasites or malignant transformation. Although NK cells do not express classical antigen receptors of the immunoglobulin gene family, such as the antibodies produced by B cells or the T cell receptor expressed by T cells, they are equipped with various receptors whose engagement allows them to discriminate between target and nontarget cells. Activating receptors bind ligands on the target cell surface and trigger NK cell activation and target cell lysis. However Inhibitory receptors recognize MHC class I molecules (HLA) and inhibit killing by NK cells by overruling the actions of the activating receptors. This inhibitory signal is lost when the target cells do not express MHC class I and perhaps also in cells infected with virus, which might inhibit MHC class I exprssion or alter its conformation. The mechanism of NK cell killing is the same as that used by the cytotoxic T cells generated in an adaptive immune response; cytotoxic granules are released onto the surface of the bound target cell, and the effector proteins they contain penetrate the cell membrane and induce programmed cell death. More...

KLRK1 related BioCarta pathways (count: 0)

KLRK1 related Reactome pathways (count: 2)

ID	Name	Description
Gene mapped Reactome pathways
REACT_6900	signaling in_immune_system	Humans are exposed to millions of potential pathogens daily,...... Humans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first critical hours and days of exposure to a new pathogen, our innate immune system. More...
REACT_11152	immunoregulatory interactions_between_a_lymphoid_and_a_non_lymphoid_cell	A number of receptors and cell adhesion molecules play a key...... A number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathogenic organisms. Molecules such as KIRs and LILRs form part of a crucial surveillance system that looks out for any derangement, usually caused by cancer or viral infection, in MHC Class I presentation. Somatic cells are also able to report internal functional impairment by displaying surface stress markers such as MICA. The presence of these molecules on somatic cells is picked up by C-lectin NK immune receptors. Lymphoid cells are able to regulate their location and movement in accordance to their state of activation, and home in on tissues expressing the appropriate complementary ligands. For example, lymphoid cells may fine tune the presence and concentration of adhesion molecules belonging to the IgSF, Selectin and Integrin class that interact with a number of vascular markers of inflammation. Furthermore, there are a number of avenues through which lymphoid cells may interact with antigen. This may be presented directly to a specific T-cell receptor in the context of an MHC molecule. Antigen-antibody complexes may anchor to the cell via a small number of lymphoid-specific Fc receptors that may, in turn, influence cell function further. Activated complement factor C3d binds to both antigen and to cell surface receptor CD21. In such cases, the far-reaching influence of CD19 on B-lymphocyte function is tempered by its interaction with CD21. More...

KLRK1 related interactors from protein-protein interaction data in HPRD (count: 8)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
KLRK1	RAET1G	No	in vitro	15240696
KLRK1	KLRK1	Yes	in vitro	10367903 , 10426993 , 11323699 , 11754823
KLRK1	TYROBP	No	in vivo	12426564
KLRK1	HCST	No	in vitro;in vivo	10426994
KLRK1	ULBP3	No	in vitro	11754823
KLRK1	MICA	No	in vitro	10426993 , 12902493
KLRK1	MICB	No	in vitro	12902493
KLRK1	RAET1E	No	in vitro;in vivo	12732206 , 14508119

Gene Report

Gene mapped KEGG pathways

Gene mapped Reactome pathways