Gene Report

Basic Information

Approved Symbol	KLRK1
Approved Name	killer cell lectin-like receptor subfamily K, member 1
Previous Symbol	D12S2489E
Previous Name	"DNA segment on chromosome 12 (unique) 2489 expressed sequence"
Symbol Alias	NKG2D, KLR, NKG2-D, CD314
Location	12p13.2-p12.3
Position	chr12:10542542-10542653 (-)
External Links	Entrez Gene: 22914 Ensembl: ENSG00000213809 UCSC: uc009zhj.3 HGNC ID: 18788
No. of Studies (Positive/Negative)	2(2/0)
Type	Literature-origin

Positive relationships between KLRK1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
KLRK1	Jansen R, 2015	patients and normal controls	P-value=0.0000131;FDR=0.0363;beta=-0.265	P-values, FDR and betas of 18 genes differentially expressed...... P-values, FDR and betas of 18 genes differentially expressed between control and current MDD groups (FDR<0.05) More...

Positive relationships between KLRK1 and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
Klrk1		Histone-lysine N-methyltransferase SETDB1(Setdb1 (Set domain, bifurcated 1))	protein	Jiang Y, 2010	animal model		Gene was occupied by Setdb1 in neuron Gene was occupied by Setdb1 in neuron

Positive relationship network of KLRK1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between KLRK1 and MDD (count: 0)

Negative relationships between KLRK1 and other components at different levels (count: 0)

KLRK1 related SNPs in MK4MDD (count: 0)

KLRK1 related proteins in MK4MDD (count: 0)

KLRK1 related GO terms (count: 30)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0043065	positive regulation of apoptotic process	biological process	IEA
GO:0004872	receptor activity	molecular function	TAS[2007850]
GO:0005887	integral component of plasma membrane	cellular component	TAS[2007850]
GO:0030246	carbohydrate binding	molecular function	IEA
GO:0032729	positive regulation of interferon-gamma production	biological process	IEA
GO:0045429	positive regulation of nitric oxide biosynthetic process	biological process	IEA
GO:0007165	signal transduction	biological process	TAS[2007850]
GO:0030887	positive regulation of myeloid dendritic cell activation	biological process	IEA
GO:0005515	protein binding	molecular function	IPI[10426993\|10426994\|11323699\|15240696\|21712812]
GO:0034260	negative regulation of GTPase activity	biological process	IDA[22585739]
GO:0030154	cell differentiation	biological process	IEA
GO:0071222	cellular response to lipopolysaccharide	biological process	IEA
GO:0002223	stimulatory C-type lectin receptor signaling pathway	biological process	IEA
GO:0032394	MHC class Ib receptor activity	molecular function	IEA
GO:0009986	cell surface	cellular component	IDA[10426994\|15294961]
GO:0016021	integral component of membrane	cellular component	TAS[9683661]
GO:0042288	MHC class I protein binding	molecular function	IEA
GO:0031295	T cell costimulation	biological process	TAS[18676862]
GO:0002860	positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	biological process	IEA
GO:0030101	natural killer cell activation	biological process	TAS[18676862]
GO:0050776	regulation of immune response	biological process	TAS
GO:0050830	defense response to Gram-positive bacterium	biological process	IEA
GO:0005886	plasma membrane	cellular component	TAS
GO:2000502	negative regulation of natural killer cell chemotaxis	biological process	IDA[22585739]
GO:0042803	protein homodimerization activity	molecular function	IEA
GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	biological process	IDA[15294961]
GO:0002250	adaptive immune response	biological process	IEA
GO:0045087	innate immune response	biological process	TAS
GO:0009897	external side of plasma membrane	cellular component	IEA
GO:0019900	kinase binding	molecular function	IEA

KLRK1 related KEGG pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04650	natural killer_cell_mediated_cytotoxicity	Natural killer cell mediated cytotoxicity	Natural killer (NK) cells are lymphocytes of the innate immu...... Natural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stress, such as infection with viruses, bacteria, or parasites or malignant transformation. Although NK cells do not express classical antigen receptors of the immunoglobulin gene family, such as the antibodies produced by B cells or the T cell receptor expressed by T cells, they are equipped with various receptors whose engagement allows them to discriminate between target and nontarget cells. Activating receptors bind ligands on the target cell surface and trigger NK cell activation and target cell lysis. However Inhibitory receptors recognize MHC class I molecules (HLA) and inhibit killing by NK cells by overruling the actions of the activating receptors. This inhibitory signal is lost when the target cells do not express MHC class I and perhaps also in cells infected with virus, which might inhibit MHC class I exprssion or alter its conformation. The mechanism of NK cell killing is the same as that used by the cytotoxic T cells generated in an adaptive immune response; cytotoxic granules are released onto the surface of the bound target cell, and the effector proteins they contain penetrate the cell membrane and induce programmed cell death. More...

KLRK1 related BioCarta pathways (count: 0)

KLRK1 related Reactome pathways (count: 2)

ID	Name	Description
Gene mapped Reactome pathways
REACT_6900	signaling in_immune_system	Humans are exposed to millions of potential pathogens daily,...... Humans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first critical hours and days of exposure to a new pathogen, our innate immune system. More...
REACT_11152	immunoregulatory interactions_between_a_lymphoid_and_a_non_lymphoid_cell	A number of receptors and cell adhesion molecules play a key...... A number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathogenic organisms. Molecules such as KIRs and LILRs form part of a crucial surveillance system that looks out for any derangement, usually caused by cancer or viral infection, in MHC Class I presentation. Somatic cells are also able to report internal functional impairment by displaying surface stress markers such as MICA. The presence of these molecules on somatic cells is picked up by C-lectin NK immune receptors. Lymphoid cells are able to regulate their location and movement in accordance to their state of activation, and home in on tissues expressing the appropriate complementary ligands. For example, lymphoid cells may fine tune the presence and concentration of adhesion molecules belonging to the IgSF, Selectin and Integrin class that interact with a number of vascular markers of inflammation. Furthermore, there are a number of avenues through which lymphoid cells may interact with antigen. This may be presented directly to a specific T-cell receptor in the context of an MHC molecule. Antigen-antibody complexes may anchor to the cell via a small number of lymphoid-specific Fc receptors that may, in turn, influence cell function further. Activated complement factor C3d binds to both antigen and to cell surface receptor CD21. In such cases, the far-reaching influence of CD19 on B-lymphocyte function is tempered by its interaction with CD21. More...

KLRK1 related interactors from protein-protein interaction data in HPRD (count: 8)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
KLRK1	RAET1G	No	in vitro	15240696
KLRK1	KLRK1	Yes	in vitro	10367903 , 10426993 , 11323699 , 11754823
KLRK1	HCST	No	in vitro;in vivo	10426994
KLRK1	MICB	No	in vitro	12902493
KLRK1	TYROBP	No	in vivo	12426564
KLRK1	ULBP3	No	in vitro	11754823
KLRK1	RAET1E	No	in vitro;in vivo	12732206 , 14508119
KLRK1	MICA	No	in vitro	10426993 , 12902493

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped Reactome pathways