Gene Report

Basic Information

Approved Symbol	ACSL4
Approved Name	acyl-CoA synthetase long-chain family member 4
Previous Symbol	FACL4, MRX63, MRX68
Previous Name	"fatty-acid-Coenzyme A ligase, long-chain 4", "mental retardation, X-linked 63", "mental retardation, X-linked 68"
Symbol Alias	ACS4, LACS4
Name Alias	"lignoceroyl-CoA synthase", " long-chain fatty-acid-Coenzyme A ligase 4"
Location	Xq22.3-q23
Position	chrX:108976368-108976514 (-)
External Links	Entrez Gene: 2182 Ensembl: ENSG00000068366 UCSC: uc004eoi.2 HGNC ID: 3571
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between ACSL4 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
FACL4	Covault J, 2004	Patients and nomal controls	P = 0.003	We observed a significant excess of the T allele in subjects...... We observed a significant excess of the T allele in subjects with major depression, as compared with controls (49% vs. 38%; P = 0.003) More...

Positive relationships between ACSL4 and other components at different levels (count: 0)

Positive relationship network of ACSL4 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between ACSL4 and MDD (count: 0)

Negative relationships between ACSL4 and other components at different levels (count: 0)

ACSL4 related SNPs in MK4MDD (count: 0)

ACSL4 related proteins in MK4MDD (count: 0)

ACSL4 related GO terms (count: 29)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0070672	response to interleukin-15	biological process	IEA
GO:0043025	neuronal cell body	cellular component	IEA
GO:0016020	membrane	cellular component	IDA[19946888]
GO:0031957	very long-chain fatty acid-CoA ligase activity	molecular function	IMP[11889465]
GO:0060996	dendritic spine development	biological process	IEA
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0004467	long-chain fatty acid-CoA ligase activity	molecular function	IDA[10669417\|21242590]
GO:0044281	small molecule metabolic process	biological process	TAS
GO:0007584	response to nutrient	biological process	IEA
GO:0005524	ATP binding	molecular function	IEA
GO:0001676	long-chain fatty acid metabolic process	biological process	IDA[10669417\|21242590]; IEA
GO:0016021	integral component of membrane	cellular component	IEA
GO:0019432	triglyceride biosynthetic process	biological process	TAS
GO:0044233	ER-mitochondrion membrane contact site	cellular component	IDA[23455425]
GO:0044255	cellular lipid metabolic process	biological process	TAS
GO:0060136	embryonic process involved in female pregnancy	biological process	IEA
GO:0015908	fatty acid transport	biological process	IEA
GO:0008610	lipid biosynthetic process	biological process	IDA[21242590]
GO:0035338	long-chain fatty-acyl-CoA biosynthetic process	biological process	TAS
GO:0047676	arachidonate-CoA ligase activity	molecular function	IDA[9598324\|21242590]
GO:0030307	positive regulation of cell growth	biological process	IDA[17934335]
GO:0005778	peroxisomal membrane	cellular component	IEA
GO:0005737	cytoplasm	cellular component	IDA[11889465]
GO:0005789	endoplasmic reticulum membrane	cellular component	TAS
GO:0006629	lipid metabolic process	biological process	IDA[9598324]
GO:0005741	mitochondrial outer membrane	cellular component	IEA
GO:0032307	negative regulation of prostaglandin secretion	biological process	IDA[21242590]
GO:0005811	lipid particle	cellular component	IDA[14741744]
GO:0070062	extracellular exosome	cellular component	IDA[19056867\|20458337\|23376485]

ACSL4 related KEGG pathways (count: 4)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04920	adipocytokine signaling_pathway	Adipocytokine signaling pathway	Increased adipocyte volume and number are positively correla...... Increased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and metabolic rate primarily by acting at hypothalamic nuclei. Leptin exerts its anorectic effects by modulating the levels of neuropeptides such as NPY, AGRP, and alpha-MSH. This leptin action is through the JAK kinase, STAT3 phosphorylation, and nuclear transcriptional effect. Adiponectin lowers plasma glucose and FFAs. These effects are partly accounted for by adiponectin-induced AMPK activation, which in turn stimulates skeletal muscle fatty acid oxidation and glucose uptake. Furthermore, activation of AMPK by adiponectin suppresses endogenous glucose production, concomitantly with inhibition of PEPCK and G6Pase expression. The proinflammatory cytokine TNFalpha has been implicated as a link between obesity and insulin resistance. TNFalpha interferes with early steps of insulin signaling. Several data have shown that TNFalpha inhibits IRS1 tyrosine phosphorylation by promoting its serine phosphorylation. Among the serine/threonine kinases activated by TNFalpha, JNK, mTOR and IKK have been shown to be involved in this phosphorylation. More...
hsa00071	fatty acid_metabolism	Fatty acid metabolism
hsa04146	peroxisome	Peroxisome	Peroxisomes are essential organelles that play a key role in...... Peroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification. The biogenesis of peroxisomes starts with the early peroxins PEX3, PEX16 and PEX19 and proceeds via several steps. The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. Peroxisomes' deficiencies lead to severe and often fatal inherited peroxisomal disorders (PD). PDs are usually classified in two groups. The first group is disorders of peroxisome biogenesis which include Zellweger syndrome, and the second group is single peroxisomal enzyme deficiencies. More...
hsa03320	ppar signaling_pathway	PPAR signaling pathway	Peroxisome proliferator-activated receptors (PPARs) are nucl...... Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake. More...

ACSL4 related BioCarta pathways (count: 0)

ACSL4 related Reactome pathways (count: 0)

ACSL4 related interactors from protein-protein interaction data in HPRD (count: 0)

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways