Gene Report

Basic Information

Approved Symbol	RAB4B
Approved Name	RAB4B, member RAS oncogene family
Symbol Alias	FLJ78649, MGC52123
Name Alias	ras-related GTP-binding protein 4b, "small GTP binding protein RAB4B"
Location	19q13.2
Position	chr19:41284124-41302849 (+)
External Links	Entrez Gene: 53916 Ensembl: ENSG00000167578 UCSC: uc002opd.2 HGNC ID: 9782
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between RAB4B and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
RAB4B	Kang HJ, 2012	patients and normal controls		Here we use microarray gene profiling and electron microscop...... Here we use microarray gene profiling and electron microscopic stereology to reveal lower expression of synaptic-function-related genes (CALM2, SYN1, RAB3A, RAB4B and TUBB4) in the dlPFC of subjects with MDD and a corresponding lower number of synapses. We also identify a transcriptional repressor, GATA1, expression of which is higher in MDD More...

Positive relationships between RAB4B and other components at different levels (count: 0)

Positive relationship network of RAB4B in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between RAB4B and MDD (count: 0)

Negative relationships between RAB4B and other components at different levels (count: 0)

RAB4B related SNPs in MK4MDD (count: 0)

RAB4B related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Ras-related protein Rab-4B	P61018	0(0/0)	Gene mapped

RAB4B related GO terms (count: 10)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0032553	ribonucleotide binding	molecular function	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0015031	protein transport	biological process	IEA
GO:0005525	GTP binding	molecular function	IEA
GO:0005886	plasma membrane	cellular component	IEA
GO:0003924	GTPase activity	molecular function	NAS
GO:0006184	GTP catabolic process	biological process	NAS
GO:0005622	intracellular	cellular component	NAS
GO:0007264	small GTPase mediated signal transduction	biological process	IEA
GO:0016192	vesicle-mediated transport	biological process	NAS

RAB4B related KEGG pathways (count: 0)

RAB4B related BioCarta pathways (count: 0)

RAB4B related Reactome pathways (count: 0)

RAB4B related interactors from protein-protein interaction data in HPRD (count: 1)

Gene Report

Literature-origin GO terms

Gene mapped GO terms