Gene Report

Basic Information

Approved Symbol	S100B
Approved Name	S100 calcium binding protein B
Previous Name	S100 calcium binding protein, beta (neural)
Symbol Alias	S100beta
Location	21q22.3
Position	chr21:48018531-48025035 (-)
External Links	Entrez Gene: 6285 Ensembl: ENSG00000160307 UCSC: uc002zju.1 HGNC ID: 10500
No. of Studies (Positive/Negative)	3(1/2)
Type	Literature-origin; Protein mapped

Positive relationships between S100B and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
S100B	Klempan, 2009	patients and normal controls		Selected differentially expressed genes in BA44 to BA47 (ANO...... Selected differentially expressed genes in BA44 to BA47 (ANOVA and t-test P < 0.01, fold change 1.3t) More...

Positive relationships between S100B and other components at different levels (count: 0)

Positive relationship network of S100B in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between S100B and MDD (count: 2)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
S100B	Yang K, 2008	Patients and nomal controls		There were no significant differences in the genotype distri...... There were no significant differences in the genotype distribution and allele frequencies between major depressive patients and healthy individuals More...
S100B	Yang K, 2009	Patients and nomal controls		Two single nucleotide polymorphisms did not display signific...... Two single nucleotide polymorphisms did not display significant associations with MDD. More...

Negative relationships between S100B and other components at different levels (count: 0)

S100B related SNPs in MK4MDD (count: 0)

S100B related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Protein S100-B	P04271	4(4/0)	Literature-origin

S100B related GO terms (count: 33)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005509	calcium ion binding	molecular function	NAS[9519411]
GO:0044548	S100 protein binding	molecular function	IPI[10913138]
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	biological process	IDA[15033494]
GO:0008360	regulation of cell shape	biological process	IEA
GO:0005515	protein binding	molecular function	IPI[16189514]
GO:0007417	central nervous system development	biological process	TAS[8202493]
GO:0048306	calcium-dependent protein binding	molecular function	IDA[10913138]
GO:0005634	nucleus	cellular component	IDA[10913138]
GO:0008270	zinc ion binding	molecular function	ISS
GO:0048168	regulation of neuronal synaptic plasticity	biological process	IEA
GO:0071456	cellular response to hypoxia	biological process	IEA
GO:0051597	response to methylmercury	biological process	IEA
GO:0005737	cytoplasm	cellular component	IDA[10913138]; ISS
GO:0005576	extracellular region	cellular component	TAS
GO:0042803	protein homodimerization activity	molecular function	IDA[10913138]; IPI[9519411]
GO:0051384	response to glucocorticoid stimulus	biological process	IEA
GO:0042802	identical protein binding	molecular function	IPI[10913138]
GO:0001726	ruffle	cellular component	IDA[10913138]
GO:0050786	RAGE receptor binding	molecular function	IPI[15033494]
GO:0045087	innate immune response	biological process	TAS
GO:0060291	long-term synaptic potentiation	biological process	IEA
GO:0007613	memory	biological process	IEA
GO:2001015	negative regulation of skeletal muscle cell differentiation	biological process	IEA
GO:0043065	positive regulation of apoptotic process	biological process	IEA
GO:0048156	tau protein binding	molecular function	ISS
GO:0007611	learning or memory	biological process	ISS
GO:0008284	positive regulation of cell proliferation	biological process	IEA
GO:0007409	axonogenesis	biological process	TAS[8202493]
GO:0048708	astrocyte differentiation	biological process	IEA
GO:0048471	perinuclear region of cytoplasm	cellular component	IDA[15033494]
GO:0043025	neuronal cell body	cellular component	IEA
GO:0008283	cell proliferation	biological process	TAS[8202493]
GO:0005615	extracellular space	cellular component	IEA

S100B related KEGG pathways (count: 0)

S100B related BioCarta pathways (count: 0)

S100B related Reactome pathways (count: 0)

S100B related interactors from protein-protein interaction data in HPRD (count: 20)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
S100B	S100B	Yes	in vitro	9335118 , 9519411
S100B	TNIP1	No	in vitro;yeast 2-hybrid	9923610
S100B	S100A11	No	in vivo;yeast 2-hybrid	10913138
S100B	NDRG1	No	in vitro;in vivo	12493777
S100B	CACYBP	No	in vitro;in vivo	12042313
S100B	AGER	No	in vivo	10399917
S100B	IQGAP1	No	in vitro;in vivo	12377780
S100B	DES	No	in vitro	10510252
S100B	GUCY2D	No	in vivo	15556616
S100B	ANXA6	Yes	in vitro	9883272
S100B	SUGT1	No	in vitro	12746458
S100B	S100A1	No	in vivo;yeast 2-hybrid	10913138 , 9925766
S100B	TP53	No	in vitro	11527429 , 10876243
S100B	AHNAK	No	in vitro;in vivo	11312263
S100B	STK38	No	in vitro	9774336 , 14661952
S100B	S100A6	No	in vivo;yeast 2-hybrid	9925766 , 10913138
S100B	CAPZA1	No	in vitro	12470955
S100B	GFAP	Yes	in vitro	10510252
S100B	PGM1	No	in vitro	8894274
S100B	MAPT	No	in vitro;in vivo	2833519 , 11264299

Gene Report

Gene mapped GO terms