Gene Report

Basic Information

Approved Symbol	ANXA6
Approved Name	annexin A6
Previous Symbol	ANX6
Location	5q33.1
Position	chr5:150480267-150537443 (-)
External Links	Entrez Gene: 309 Ensembl: ENSG00000197043 UCSC: uc003ltl.2 HGNC ID: 544
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between ANXA6 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
Annexin VI	Tochigi, 2008	patients and normal controls		Genes differentially expressed in major depression Genes differentially expressed in major depression

Positive relationships between ANXA6 and other components at different levels (count: 0)

Positive relationship network of ANXA6 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between ANXA6 and MDD (count: 0)

Negative relationships between ANXA6 and other components at different levels (count: 0)

ANXA6 related SNPs in MK4MDD (count: 0)

ANXA6 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Annexin A6	P08133	0(0/0)	Gene mapped

ANXA6 related GO terms (count: 8)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0042470	melanosome	cellular component	IEA
GO:0048471	perinuclear region of cytoplasm	cellular component	IEA
GO:0005544	calcium-dependent phospholipid binding	molecular function	IDA[2138016]
GO:0070062	extracellular vesicular exosome	cellular component	IDA
GO:0006937	regulation of muscle contraction	biological process	IEA
GO:0005515	protein binding	molecular function	IPI[15576473]
GO:0006816	calcium ion transport	biological process	IEA
GO:0005509	calcium ion binding	molecular function	IEA

ANXA6 related KEGG pathways (count: 0)

ANXA6 related BioCarta pathways (count: 0)

ANXA6 related Reactome pathways (count: 0)

ANXA6 related interactors from protein-protein interaction data in HPRD (count: 7)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
ANXA6	CDC73	No	yeast 2-hybrid	16169070
ANXA6	S100A1	No	in vitro	9883272
ANXA6	TPD52	No	in vivo	15576473
ANXA6	CR2	No	in vitro	1831222
ANXA6	S100B	Yes	in vitro	9883272
ANXA6	RASA1	No	in vitro;in vivo	8798684 , 10571081
ANXA6	A2M	No	in vitro	15226301

Gene Report

Gene mapped GO terms