Gene Report

Basic Information

Approved Symbol	GFAP
Approved Name	glial fibrillary acidic protein
Symbol Alias	FLJ45472
Name Alias	intermediate filament protein
Location	17q21
Position	chr17:42982994-42992920 (-)
External Links	Entrez Gene: 2670 Ensembl: ENSG00000131095 UCSC: uc021tyh.1 HGNC ID: 4235
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin; Protein mapped

Positive relationships between GFAP and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
GFAP	Guilloux JP, 2012	patients and normal controls		genes significantly affected in female MDD subjects genes significantly affected in female MDD subjects

Positive relationships between GFAP and other components at different levels (count: 0)

Positive relationship network of GFAP in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between GFAP and MDD (count: 0)

Negative relationships between GFAP and other components at different levels (count: 0)

GFAP related SNPs in MK4MDD (count: 0)

GFAP related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Glial fibrillary acidic protein	P14136	7(7/0)	Literature-origin

GFAP related GO terms (count: 19)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005737	cytoplasm	cellular component	IDA[12355421]
GO:0010625	positive regulation of Schwann cell proliferation	biological process	IEA
GO:0009611	response to wounding	biological process	IEA
GO:0045109	intermediate filament organization	biological process	IEA
GO:0014002	astrocyte development	biological process	IEA
GO:0016020	membrane	cellular component	IEA
GO:0005829	cytosol	cellular component	TAS
GO:0031102	neuron projection regeneration	biological process	IEA
GO:0005200	structural constituent of cytoskeleton	molecular function	IEA
GO:0019900	kinase binding	molecular function	IEA
GO:0060291	long-term synaptic potentiation	biological process	IEA
GO:0030198	extracellular matrix organization	biological process	IEA
GO:0010977	negative regulation of neuron projection development	biological process	IEA
GO:0005882	intermediate filament	cellular component	IEA
GO:0005178	integrin binding	molecular function	IEA
GO:0060020	Bergmann glial cell differentiation	biological process	IEA
GO:0044297	cell body	cellular component	IEA
GO:0042995	cell projection	cellular component	IEA
GO:0051580	regulation of neurotransmitter uptake	biological process	IEA

GFAP related KEGG pathways (count: 0)

GFAP related BioCarta pathways (count: 0)

GFAP related Reactome pathways (count: 0)

GFAP related interactors from protein-protein interaction data in HPRD (count: 21)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
GFAP	TUBGCP4	No	yeast 2-hybrid	16189514
GFAP	SH3YL1	No	yeast 2-hybrid	16189514
GFAP	PRKCA	No	in vitro;in vivo	2155236 , 9099667 , 7822264 , 2114109
GFAP	CEP76	No	yeast 2-hybrid	16189514
GFAP	KIAA0408	No	yeast 2-hybrid	16189514
GFAP	PDLIM7	No	yeast 2-hybrid	16189514
GFAP	S100B	Yes	in vitro	10510252
GFAP	PDZK1	No	yeast 2-hybrid	16189514
GFAP	CDK1	No	in vitro;in vivo	7822264 , 12177195
GFAP	POM121	No	yeast 2-hybrid	16189514
GFAP	RIBC2	No	yeast 2-hybrid	16189514
GFAP	VIM	Yes	yeast 2-hybrid	16189514
GFAP	PDLIM1	No	yeast 2-hybrid	16189514
GFAP	PSEN1	Yes	in vitro;yeast 2-hybrid	12058025
GFAP	PRKACA	No	in vitro;in vivo	2155236 , 9099667 , 7822264 , 2114109
GFAP	S100A1	No	in vitro	10510252
GFAP	SRC	No	in vivo	11379820
GFAP	ROCK1	No	in vitro;in vivo	9099667 , 2155236 , 7822264 , 2114109
GFAP	MEN1	No	in vitro;in vivo	12169273
GFAP	GRAP2	No	yeast 2-hybrid	16189514
GFAP	CAMK2A	Yes	in vitro;in vivo	2155236 , 9099667 , 7822264 , 2114109

Gene Report

Gene mapped GO terms