MK4MDD

Gene Report

Basic Information
Approved Symbol ABCB1
Approved Name ATP-binding cassette, sub-family B (MDR/TAP), member 1
Previous Symbol PGY1, MDR1, CLCS
Previous Name "colchicin sensitivity"
Symbol Alias P-gp, CD243, GP170, ABC20
Name Alias "multidrug resistance protein 1"
Location 7q21.12
Position chr7:87342477-87342639 (-)
External Links Entrez Gene: 5243
Ensembl: ENSG00000085563
UCSC: uc003uiz.2
HGNC ID: 40
No. of Studies (Positive/Negative) 3(2/1) Help
Type Literature-origin; SNP mapped

Positive relationships between ABCB1 and MDD (count: 2)
Name in Literature Reference Research Type Statistical Result Relation Description Help
ABCB1 Lin, 2011 patients only P-value<0.01 The ABCB1 genotypes of rs1922242 (P=0.0028) and rs1202184 (P...... The ABCB1 genotypes of rs1922242 (P=0.0028) and rs1202184 (P=0.0021) showed significant association with the severity of depressive symptoms as assessed by the Hamilton Rating Scale for Depression adjusted with Hamilton Rating Scale for Anxiety. More...
ABCB1 Santos M, 2014 patients and normal controls A significant protection for MDD males carrying the T allele...... A significant protection for MDD males carrying the T allele was observed (C1236T: odds ratio (OR)=0.360, 95% confidence interval [CI]: [0.140-0.950], p=0.022; C3435T: OR=0.306, 95% CI: [0.096-0.980], p=0.042; and G2677TA: OR=0.300, 95% CI: [0.100-0.870], p=0.013). Male Portuguese individuals carrying the 1236T/2677T/3435T haplotype had nearly 70% less risk of developing MDD (OR=0.313, 95% CI: [0.118-0.832], p=0.016, FDR p=0.032). More...

Positive relationships between ABCB1 and other components at different levels (count: 0) Help
Positive relationship network of ABCB1 in MK4MDD
Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between ABCB1 and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description
ABCB1 Crisafulli C, 2013 patients and normal controls No association with mood disorders and clinical outcomes was...... No association with mood disorders and clinical outcomes was observed More...

Negative relationships between ABCB1 and other components at different levels (count: 0) Help
ABCB1 related SNPs in MK4MDD (count: 1)
ABCB1 related proteins in MK4MDD (count: 0)
ABCB1 related GO terms (count: 25)
ABCB1 related KEGG pathways (count: 1)
ABCB1 related BioCarta pathways (count: 2)
ABCB1 related Reactome pathways (count: 0)
ABCB1 related interactors from protein-protein interaction data in HPRD (count: 3)