MK4MDD

Gene Report

Basic Information
Approved Symbol NRG1
Approved Name neuregulin 1
Previous Symbol HGL
Symbol Alias HRG, NDF, GGF
Location 8p21-p12
Position chr8:32621921-32621992 (+)
External Links Entrez Gene: 3084
Ensembl: ENSG00000157168
UCSC: uc003xiu.2
HGNC ID: 7997
No. of Studies (Positive/Negative) 3(1/2) Help
Type Literature-origin; Protein mapped

Positive relationships between NRG1 and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description Help
NRG1 Belzeaux, 2010 patients and normal controls We found that variations of mRNA levels for NRG1, SORT1 and ...... We found that variations of mRNA levels for NRG1, SORT1 and TPH1 were interesting state-dependent biological markers of the disease. More...

Positive relationships between NRG1 and other components at different levels (count: 0) Help
Positive relationship network of NRG1 in MK4MDD
Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between NRG1 and MDD (count: 2)
Name in Literature Reference Research Type Statistical Result Relation Description
NRG1 Schosser A, 2010 Patients and nomal controls We found no single marker or haplotype associations that wi...... We found no single marker or haplotype associations that withstood correction for multiple testing. More...
NRG1 Crisafulli C, 2013 patients and normal controls No association with mood disorders and clinical outcomes was...... No association with mood disorders and clinical outcomes was observed More...

Negative relationships between NRG1 and other components at different levels (count: 0) Help
NRG1 related SNPs in MK4MDD (count: 0)
NRG1 related proteins in MK4MDD (count: 1)
NRG1 related GO terms (count: 91)
NRG1 related KEGG pathways (count: 1)
NRG1 related BioCarta pathways (count: 1)
NRG1 related Reactome pathways (count: 0)
NRG1 related interactors from protein-protein interaction data in HPRD (count: 6)