Gene Report

Basic Information

Approved Symbol	NRG1
Approved Name	neuregulin 1
Previous Symbol	HGL
Symbol Alias	HRG, NDF, GGF
Location	8p21-p12
Position	chr8:32621921-32621992 (+)
External Links	Entrez Gene: 3084 Ensembl: ENSG00000157168 UCSC: uc003xiu.2 HGNC ID: 7997
No. of Studies (Positive/Negative)	3(1/2)
Type	Literature-origin; Protein mapped

Positive relationships between NRG1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
NRG1	Belzeaux, 2010	patients and normal controls		We found that variations of mRNA levels for NRG1, SORT1 and ...... We found that variations of mRNA levels for NRG1, SORT1 and TPH1 were interesting state-dependent biological markers of the disease. More...

Positive relationships between NRG1 and other components at different levels (count: 0)

Positive relationship network of NRG1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between NRG1 and MDD (count: 2)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
NRG1	Schosser A, 2010	Patients and nomal controls		We found no single marker or haplotype associations that wi...... We found no single marker or haplotype associations that withstood correction for multiple testing. More...
NRG1	Crisafulli C, 2013	patients and normal controls		No association with mood disorders and clinical outcomes was...... No association with mood disorders and clinical outcomes was observed More...

Negative relationships between NRG1 and other components at different levels (count: 0)

NRG1 related SNPs in MK4MDD (count: 0)

NRG1 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Pro-neuregulin-1, membrane-bound isoform	Q02297	1(1/0)	Literature-origin

NRG1 related GO terms (count: 91)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0000165	MAPK cascade	biological process	TAS

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	biological process	IDA[7514177]
GO:0043125	ErbB-3 class receptor binding	molecular function	IDA[7556068]; IEA; IPI[11389077]
GO:0051048	negative regulation of secretion	biological process	IDA[10559227]
GO:0005102	receptor binding	molecular function	IPI[7514177]
GO:0030296	protein tyrosine kinase activator activity	molecular function	IDA[7556068]
GO:0031594	neuromuscular junction	cellular component	IEA
GO:0045087	innate immune response	biological process	TAS
GO:1903955	positive regulation of protein targeting to mitochondrion	biological process	IMP[24270810]
GO:0021842	chemorepulsion involved in interneuron migration from the subpallium to the cortex	biological process	IEA
GO:0021781	glial cell fate commitment	biological process	IEA
GO:0045773	positive regulation of axon extension	biological process	IEA
GO:0048010	vascular endothelial growth factor receptor signaling pathway	biological process	TAS
GO:0060956	endocardial cell differentiation	biological process	IDA[17336907]
GO:0048011	neurotrophin TRK receptor signaling pathway	biological process	TAS
GO:0007173	epidermal growth factor receptor signaling pathway	biological process	TAS
GO:0043496	regulation of protein homodimerization activity	biological process	TAS[16412517]
GO:0048663	neuron fate commitment	biological process	IEA
GO:0060045	positive regulation of cardiac muscle cell proliferation	biological process	IDA[9553078]
GO:0038095	Fc-epsilon receptor signaling pathway	biological process	TAS
GO:2000010	positive regulation of protein localization to cell surface	biological process	IEA
GO:0055012	ventricular cardiac muscle cell differentiation	biological process	IDA[9553078]
GO:0005515	protein binding	molecular function	IPI[7592681]
GO:0030425	dendrite	cellular component	IEA
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	biological process	IDA[9553078]
GO:0007154	cell communication	biological process	TAS[17432114]
GO:0046579	positive regulation of Ras protein signal transduction	biological process	IEA
GO:0043624	cellular protein complex disassembly	biological process	IGI[15155732]
GO:0007626	locomotory behavior	biological process	IEA
GO:0005176	ErbB-2 class receptor binding	molecular function	IEA
GO:0008543	fibroblast growth factor receptor signaling pathway	biological process	TAS
GO:0055007	cardiac muscle cell differentiation	biological process	ISS
GO:0005615	extracellular space	cellular component	IDA[11389077\|12646923]
GO:0042552	myelination	biological process	IEA
GO:0038127	ERBB signaling pathway	biological process	IDA[11389077]
GO:0043497	regulation of protein heterodimerization activity	biological process	IDA[10559227]
GO:0035556	intracellular signal transduction	biological process	IBA
GO:0045892	negative regulation of transcription, DNA-templated	biological process	IDA[15073182]
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	biological process	IEA
GO:0010667	negative regulation of cardiac muscle cell apoptotic process	biological process	IDA[9553078]
GO:0003161	cardiac conduction system development	biological process	IEA
GO:2000727	positive regulation of cardiac muscle cell differentiation	biological process	IEA
GO:0005576	extracellular region	cellular component	NAS[1348215\|1350381\|8096067]; TAS
GO:0003222	ventricular trabecula myocardium morphogenesis	biological process	IDA[17336907]
GO:0031643	positive regulation of myelination	biological process	IEA
GO:0009897	external side of plasma membrane	cellular component	IEA
GO:0005737	cytoplasm	cellular component	IEA
GO:0007422	peripheral nervous system development	biological process	IEA
GO:0016324	apical plasma membrane	cellular component	IDA[12646923]
GO:0044297	cell body	cellular component	IEA
GO:0000186	activation of MAPKK activity	biological process	TAS
GO:0045785	positive regulation of cell adhesion	biological process	IDA[7556068]
GO:0045213	neurotransmitter receptor metabolic process	biological process	IEA
GO:0061098	positive regulation of protein tyrosine kinase activity	biological process	IDA[7556068]
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IEA
GO:0016020	membrane	cellular component	NAS[8096067]
GO:0008283	cell proliferation	biological process	IDA[11389077]
GO:0009790	embryo development	biological process	IEA
GO:0042177	negative regulation of protein catabolic process	biological process	IEA
GO:0005125	cytokine activity	molecular function	TAS[10372964]
GO:0001964	startle response	biological process	IEA
GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	molecular function	IC[9553078]; NAS[1348215\|1350381]
GO:0030673	axolemma	cellular component	IEA
GO:0060999	positive regulation of dendritic spine development	biological process	IEA
GO:0048709	oligodendrocyte differentiation	biological process	IEA
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	biological process	IEA
GO:0070886	positive regulation of calcineurin-NFAT signaling cascade	biological process	IEA
GO:0007416	synapse assembly	biological process	IEA
GO:0005634	nucleus	cellular component	IEA
GO:0014032	neural crest cell development	biological process	TAS[17432114]
GO:0048015	phosphatidylinositol-mediated signaling	biological process	TAS
GO:0008083	growth factor activity	molecular function	IDA[11389077]; NAS[8096067]
GO:0051155	positive regulation of striated muscle cell differentiation	biological process	ISS
GO:0007264	small GTPase mediated signal transduction	biological process	TAS
GO:2001223	negative regulation of neuron migration	biological process	IEA
GO:0003712	transcription cofactor activity	molecular function	IDA[15073182]
GO:0030307	positive regulation of cell growth	biological process	IDA[9553078]
GO:0045499	chemorepellent activity	molecular function	IEA
GO:0007265	Ras protein signal transduction	biological process	TAS
GO:0007411	axon guidance	biological process	TAS
GO:0008217	regulation of blood pressure	biological process	IEA
GO:0030971	receptor tyrosine kinase binding	molecular function	NAS[1348215\|1350381]
GO:0007399	nervous system development	biological process	TAS[17432114]
GO:0042060	wound healing	biological process	IDA[12646923]; TAS[16412517]
GO:0005887	integral component of plasma membrane	cellular component	IEA
GO:0060379	cardiac muscle cell myoblast differentiation	biological process	IDA[17336907]
GO:0051897	positive regulation of protein kinase B signaling	biological process	IEA
GO:0008286	insulin receptor signaling pathway	biological process	TAS
GO:0030879	mammary gland development	biological process	TAS[17432114]
GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity	biological process	IDA[9553078]; NAS[1348215\|1350381]
GO:0015758	glucose transport	biological process	IEA

NRG1 related KEGG pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04012	erbb signaling_pathway	ErbB signaling pathway	The ErbB family of receptor tyrosine kinases (RTKs) couples ...... The ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including proliferation, differentiation, cell motility, and survival. Ligand binding to the four closely related members of this RTK family -epidermal growth factor receptor (EGFR, also known as ErbB-1 or HER1), ErbB-2 (HER2), ErbB-3 (HER3), and ErbB-4 (HER4)-induces the formation of receptor homo- and heterodimers and the activation of the intrinsic kinase domain, resulting in phosphorylation on specific tyrosine residues (pY) within the cytoplasmic tail. Signaling effectors containing binding pockets for pY-containing peptides are recruited to activated receptors and induce the various signaling pathways. The Shc- and/or Grb2-activated mitogen-activated protein kinase (MAPK) pathway is a common target downstream of all ErbB receptors. Similarly, the phosphatidylinositol-3-kinase (PI-3K) pathway is directly or indirectly activated by most ErbBs. Several cytoplasmic docking proteins appear to be recruited by specific ErbB receptors and less exploited by others. These include the adaptors Crk, Nck, the phospholipase C gamma (PLCgamma), the intracellular tyrosine kinase Src, or the Cbl E3 ubiquitin protein ligase. More...

NRG1 related BioCarta pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped BioCarta pathways
AGR_PATHWAY	agr pathway	Agrin in Postsynaptic Differentiation	The heparan sulphate proteoglycan agrin is well known as the...... The heparan sulphate proteoglycan agrin is well known as the key assembly factor of postsynaptic differentiation at the neuromuscular junction (NMJ), but recent data suggest it also plays a direct role in the organization of the cytoskeleton in the skeletal muscle. Signaling through muscle-specific proteins such as muscle specific kinase (MuSK) and or acetylcholine receptor (AchRs)/rapsyn, agrin can activate ubiquitously expressed Rac, Cdc42, and p21-activated kinase (PAK) that are involved in actin polymerization. Agrin also engages signaling pathways of several potent oncogenes (i.e., SFK, ErbB receptors, and cortactin). More...

NRG1 related Reactome pathways (count: 0)

NRG1 related interactors from protein-protein interaction data in HPRD (count: 6)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
NRG1	IKZF4	No	in vitro;in vivo	15494726
NRG1	ERBB4	No	in vitro;in vivo	8062828 , 10537356 , 7721889 , 9565587
NRG1	ADAM19	No	in vitro	11116142
NRG1	ERBB3	Yes	in vitro	7592681 , 11555649 , 9565587 , 8702572
NRG1	LIMK1	No	in vitro;yeast 2-hybrid	9685409
NRG1	EGF	Yes	in vitro	7730382

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped BioCarta pathways