
Gene Report
Approved Symbol | NRG1 |
---|---|
Approved Name | neuregulin 1 |
Previous Symbol | HGL |
Symbol Alias | HRG, NDF, GGF |
Location | 8p21-p12 |
Position | chr8:32621921-32621992 (+) |
External Links |
Entrez Gene: 3084 Ensembl: ENSG00000157168 UCSC: uc003xiu.2 HGNC ID: 7997 |
No. of Studies (Positive/Negative) | 3(1/2)
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Type | Literature-origin; Protein mapped |
Name in Literature | Reference | Research Type | Statistical Result | Relation Description | ![]() |
---|---|---|---|---|---|
NRG1 | Belzeaux, 2010 | patients and normal controls | We found that variations of mRNA levels for NRG1, SORT1 and ...... We found that variations of mRNA levels for NRG1, SORT1 and TPH1 were interesting state-dependent biological markers of the disease. More... |
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus | Protein and Other Molecule | Cell and Molecular Pathway | Neural System | Cognition and Behavior | Symptoms and Signs | Environment | MDD |
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2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Name in Literature | Reference | Research Type | Statistical Result | Relation Description |
---|---|---|---|---|
NRG1 | Schosser A, 2010 | Patients and nomal controls | We found no single marker or haplotype associations that wi...... We found no single marker or haplotype associations that withstood correction for multiple testing. More... | |
NRG1 | Crisafulli C, 2013 | patients and normal controls | No association with mood disorders and clinical outcomes was...... No association with mood disorders and clinical outcomes was observed More... |
Approved Name | UniportKB | No. of Studies (Positive/Negative) | Source | |
---|---|---|---|---|
Pro-neuregulin-1, membrane-bound isoform | Q02297 | 1(1/0) | Literature-origin |
Literature-origin GO terms | ||||
ID | Name | Type | Evidence | |
---|---|---|---|---|
GO:0000165 | MAPK cascade | biological process | TAS |
Gene mapped GO terms | ||||
ID | Name | Type | Evidence | |
---|---|---|---|---|
GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | biological process | IDA[7514177] | |
GO:0043125 | ErbB-3 class receptor binding | molecular function | IDA[7556068]; IEA; IPI[11389077] | |
GO:0051048 | negative regulation of secretion | biological process | IDA[10559227] | |
GO:0005102 | receptor binding | molecular function | IPI[7514177] | |
GO:0030296 | protein tyrosine kinase activator activity | molecular function | IDA[7556068] | |
GO:0031594 | neuromuscular junction | cellular component | IEA | |
GO:0045087 | innate immune response | biological process | TAS | |
GO:1903955 | positive regulation of protein targeting to mitochondrion | biological process | IMP[24270810] | |
GO:0021842 | chemorepulsion involved in interneuron migration from the subpallium to the cortex | biological process | IEA | |
GO:0021781 | glial cell fate commitment | biological process | IEA | |
GO:0045773 | positive regulation of axon extension | biological process | IEA | |
GO:0048010 | vascular endothelial growth factor receptor signaling pathway | biological process | TAS | |
GO:0060956 | endocardial cell differentiation | biological process | IDA[17336907] | |
GO:0048011 | neurotrophin TRK receptor signaling pathway | biological process | TAS | |
GO:0007173 | epidermal growth factor receptor signaling pathway | biological process | TAS | |
GO:0043496 | regulation of protein homodimerization activity | biological process | TAS[16412517] | |
GO:0048663 | neuron fate commitment | biological process | IEA | |
GO:0060045 | positive regulation of cardiac muscle cell proliferation | biological process | IDA[9553078] | |
GO:0038095 | Fc-epsilon receptor signaling pathway | biological process | TAS | |
GO:2000010 | positive regulation of protein localization to cell surface | biological process | IEA | |
GO:0055012 | ventricular cardiac muscle cell differentiation | biological process | IDA[9553078] | |
GO:0005515 | protein binding | molecular function | IPI[7592681] | |
GO:0030425 | dendrite | cellular component | IEA | |
GO:2001240 | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand | biological process | IDA[9553078] | |
GO:0007154 | cell communication | biological process | TAS[17432114] | |
GO:0046579 | positive regulation of Ras protein signal transduction | biological process | IEA | |
GO:0043624 | cellular protein complex disassembly | biological process | IGI[15155732] | |
GO:0007626 | locomotory behavior | biological process | IEA | |
GO:0005176 | ErbB-2 class receptor binding | molecular function | IEA | |
GO:0008543 | fibroblast growth factor receptor signaling pathway | biological process | TAS | |
GO:0055007 | cardiac muscle cell differentiation | biological process | ISS | |
GO:0005615 | extracellular space | cellular component | IDA[11389077|12646923] | |
GO:0042552 | myelination | biological process | IEA | |
GO:0038127 | ERBB signaling pathway | biological process | IDA[11389077] | |
GO:0043497 | regulation of protein heterodimerization activity | biological process | IDA[10559227] | |
GO:0035556 | intracellular signal transduction | biological process | IBA | |
GO:0045892 | negative regulation of transcription, DNA-templated | biological process | IDA[15073182] | |
GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | biological process | IEA | |
GO:0010667 | negative regulation of cardiac muscle cell apoptotic process | biological process | IDA[9553078] | |
GO:0003161 | cardiac conduction system development | biological process | IEA | |
GO:2000727 | positive regulation of cardiac muscle cell differentiation | biological process | IEA | |
GO:0005576 | extracellular region | cellular component | NAS[1348215|1350381|8096067]; TAS | |
GO:0003222 | ventricular trabecula myocardium morphogenesis | biological process | IDA[17336907] | |
GO:0031643 | positive regulation of myelination | biological process | IEA | |
GO:0009897 | external side of plasma membrane | cellular component | IEA | |
GO:0005737 | cytoplasm | cellular component | IEA | |
GO:0007422 | peripheral nervous system development | biological process | IEA | |
GO:0016324 | apical plasma membrane | cellular component | IDA[12646923] | |
GO:0044297 | cell body | cellular component | IEA | |
GO:0000186 | activation of MAPKK activity | biological process | TAS | |
GO:0045785 | positive regulation of cell adhesion | biological process | IDA[7556068] | |
GO:0045213 | neurotransmitter receptor metabolic process | biological process | IEA | |
GO:0061098 | positive regulation of protein tyrosine kinase activity | biological process | IDA[7556068] | |
GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | biological process | IEA | |
GO:0016020 | membrane | cellular component | NAS[8096067] | |
GO:0008283 | cell proliferation | biological process | IDA[11389077] | |
GO:0009790 | embryo development | biological process | IEA | |
GO:0042177 | negative regulation of protein catabolic process | biological process | IEA | |
GO:0005125 | cytokine activity | molecular function | TAS[10372964] | |
GO:0001964 | startle response | biological process | IEA | |
GO:0030297 | transmembrane receptor protein tyrosine kinase activator activity | molecular function | IC[9553078]; NAS[1348215|1350381] | |
GO:0030673 | axolemma | cellular component | IEA | |
GO:0060999 | positive regulation of dendritic spine development | biological process | IEA | |
GO:0048709 | oligodendrocyte differentiation | biological process | IEA | |
GO:0014068 | positive regulation of phosphatidylinositol 3-kinase signaling | biological process | IEA | |
GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade | biological process | IEA | |
GO:0007416 | synapse assembly | biological process | IEA | |
GO:0005634 | nucleus | cellular component | IEA | |
GO:0014032 | neural crest cell development | biological process | TAS[17432114] | |
GO:0048015 | phosphatidylinositol-mediated signaling | biological process | TAS | |
GO:0008083 | growth factor activity | molecular function | IDA[11389077]; NAS[8096067] | |
GO:0051155 | positive regulation of striated muscle cell differentiation | biological process | ISS | |
GO:0007264 | small GTPase mediated signal transduction | biological process | TAS | |
GO:2001223 | negative regulation of neuron migration | biological process | IEA | |
GO:0003712 | transcription cofactor activity | molecular function | IDA[15073182] | |
GO:0030307 | positive regulation of cell growth | biological process | IDA[9553078] | |
GO:0045499 | chemorepellent activity | molecular function | IEA | |
GO:0007265 | Ras protein signal transduction | biological process | TAS | |
GO:0007411 | axon guidance | biological process | TAS | |
GO:0008217 | regulation of blood pressure | biological process | IEA | |
GO:0030971 | receptor tyrosine kinase binding | molecular function | NAS[1348215|1350381] | |
GO:0007399 | nervous system development | biological process | TAS[17432114] | |
GO:0042060 | wound healing | biological process | IDA[12646923]; TAS[16412517] | |
GO:0005887 | integral component of plasma membrane | cellular component | IEA | |
GO:0060379 | cardiac muscle cell myoblast differentiation | biological process | IDA[17336907] | |
GO:0051897 | positive regulation of protein kinase B signaling | biological process | IEA | |
GO:0008286 | insulin receptor signaling pathway | biological process | TAS | |
GO:0030879 | mammary gland development | biological process | TAS[17432114] | |
GO:0007171 | activation of transmembrane receptor protein tyrosine kinase activity | biological process | IDA[9553078]; NAS[1348215|1350381] | |
GO:0015758 | glucose transport | biological process | IEA |
Gene mapped KEGG pathways | ||||
ID | Name | Brief Description | Full Description | |
---|---|---|---|---|
hsa04012 | erbb signaling_pathway | ErbB signaling pathway | The ErbB family of receptor tyrosine kinases (RTKs) couples ...... The ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including proliferation, differentiation, cell motility, and survival. Ligand binding to the four closely related members of this RTK family -epidermal growth factor receptor (EGFR, also known as ErbB-1 or HER1), ErbB-2 (HER2), ErbB-3 (HER3), and ErbB-4 (HER4)-induces the formation of receptor homo- and heterodimers and the activation of the intrinsic kinase domain, resulting in phosphorylation on specific tyrosine residues (pY) within the cytoplasmic tail. Signaling effectors containing binding pockets for pY-containing peptides are recruited to activated receptors and induce the various signaling pathways. The Shc- and/or Grb2-activated mitogen-activated protein kinase (MAPK) pathway is a common target downstream of all ErbB receptors. Similarly, the phosphatidylinositol-3-kinase (PI-3K) pathway is directly or indirectly activated by most ErbBs. Several cytoplasmic docking proteins appear to be recruited by specific ErbB receptors and less exploited by others. These include the adaptors Crk, Nck, the phospholipase C gamma (PLCgamma), the intracellular tyrosine kinase Src, or the Cbl E3 ubiquitin protein ligase. More... |
Gene mapped BioCarta pathways | ||||
ID | Name | Brief Description | Full Description | |
---|---|---|---|---|
AGR_PATHWAY | agr pathway | Agrin in Postsynaptic Differentiation | The heparan sulphate proteoglycan agrin is well known as the...... The heparan sulphate proteoglycan agrin is well known as the key assembly factor of postsynaptic differentiation at the neuromuscular junction (NMJ), but recent data suggest it also plays a direct role in the organization of the cytoskeleton in the skeletal muscle. Signaling through muscle-specific proteins such as muscle specific kinase (MuSK) and or acetylcholine receptor (AchRs)/rapsyn, agrin can activate ubiquitously expressed Rac, Cdc42, and p21-activated kinase (PAK) that are involved in actin polymerization. Agrin also engages signaling pathways of several potent oncogenes (i.e., SFK, ErbB receptors, and cortactin). More... |

Gene | Interactor | Interactor in MK4MDD? | Experiment Type | PMID | |
---|---|---|---|---|---|
NRG1 | LIMK1 | No | in vitro;yeast 2-hybrid | 9685409 | |
NRG1 | ERBB3 | Yes | in vitro | 7592681 , 11555649 , 9565587 , 8702572 | |
NRG1 | IKZF4 | No | in vitro;in vivo | 15494726 | |
NRG1 | ADAM19 | No | in vitro | 11116142 | |
NRG1 | EGF | Yes | in vitro | 7730382 | |
NRG1 | ERBB4 | No | in vitro;in vivo | 8062828 , 10537356 , 7721889 , 9565587 |