
Gene Report
Approved Symbol | NOS1 |
---|---|
Approved Name | nitric oxide synthase 1 (neuronal) |
Previous Symbol | NOS |
Symbol Alias | nNOS |
Location | 12q24.22 |
Position | chr12:117799317-117799607 (-) |
External Links |
Entrez Gene: 4842 Ensembl: ENSG00000089250 UCSC: uc001twn.2 HGNC ID: 7872 |
No. of Studies (Positive/Negative) | 1(0/1)
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Type | Literature-origin; Protein mapped |
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus | Protein and Other Molecule | Cell and Molecular Pathway | Neural System | Cognition and Behavior | Symptoms and Signs | Environment | MDD |
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2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Name in Literature | Reference | Research Type | Statistical Result | Relation Description |
---|---|---|---|---|
NOS1 | Okumura T, 2010 | Patients and nomal controls | We did not detect a significant association between NOS1 and...... We did not detect a significant association between NOS1 and MDD, BP or the fluvoxamine therapeutic response in MDD in allele/genotype-wise analysis. More... |
Approved Name | UniportKB | No. of Studies (Positive/Negative) | Source | |
---|---|---|---|---|
Nitric oxide synthase, brain | P29475 | 2(2/0) | Literature-origin |
Literature-origin GO terms | ||||
ID | Name | Type | Evidence | |
---|---|---|---|---|
GO:0043197 | dendritic spine | cellular component | IEA | |
GO:0014069 | postsynaptic density | cellular component | IEA | |
GO:0005856 | cytoskeleton | cellular component | ISS[7545544] |
Gene mapped GO terms | ||||
ID | Name | Type | Evidence | |
---|---|---|---|---|
GO:0060314 | regulation of ryanodine-sensitive calcium-release channel activity | biological process | TAS[21536106] | |
GO:0051346 | negative regulation of hydrolase activity | biological process | ISS | |
GO:0033197 | response to vitamin E | biological process | IEA | |
GO:0007596 | blood coagulation | biological process | TAS | |
GO:0006527 | arginine catabolic process | biological process | IC[7545544] | |
GO:1900273 | positive regulation of long-term synaptic potentiation | biological process | IEA | |
GO:0009408 | response to heat | biological process | IDA[18048451] | |
GO:1901206 | positive regulation of adrenergic receptor signaling pathway involved in heart process | biological process | IEA | |
GO:0055117 | regulation of cardiac muscle contraction | biological process | TAS[9892689] | |
GO:1901216 | positive regulation of neuron death | biological process | IEA | |
GO:0044325 | ion channel binding | molecular function | ISS; TAS[21536106] | |
GO:0042803 | protein homodimerization activity | molecular function | IEA | |
GO:0045909 | positive regulation of vasodilation | biological process | IDA[18048451]; IMP[18391107] | |
GO:0035066 | positive regulation of histone acetylation | biological process | ISS | |
GO:0046676 | negative regulation of insulin secretion | biological process | IEA | |
GO:0001917 | photoreceptor inner segment | cellular component | ISS[17027776] | |
GO:0048148 | behavioral response to cocaine | biological process | IEA | |
GO:0050767 | regulation of neurogenesis | biological process | IEA | |
GO:0043234 | protein complex | cellular component | ISS | |
GO:0005737 | cytoplasm | cellular component | TAS[17892502] | |
GO:0030315 | T-tubule | cellular component | IEA | |
GO:0005515 | protein binding | molecular function | IPI[11149895|17161399] | |
GO:0045906 | negative regulation of vasoconstriction | biological process | IEA | |
GO:0045471 | response to ethanol | biological process | IEA | |
GO:0042582 | azurophil granule | cellular component | IEA | |
GO:0051930 | regulation of sensory perception of pain | biological process | IEA | |
GO:0061337 | cardiac conduction | biological process | TAS | |
GO:0030018 | Z disc | cellular component | IEA | |
GO:0005901 | caveola | cellular component | IEA | |
GO:0010288 | response to lead ion | biological process | IEA | |
GO:0071731 | response to nitric oxide | biological process | IEA | |
GO:0005516 | calmodulin binding | molecular function | IEA | |
GO:0016529 | sarcoplasmic reticulum | cellular component | IDA[9892689] | |
GO:0035094 | response to nicotine | biological process | IEA | |
GO:0010523 | negative regulation of calcium ion transport into cytosol | biological process | TAS[17568574] | |
GO:0007520 | myoblast fusion | biological process | TAS[7545544] | |
GO:0006809 | nitric oxide biosynthetic process | biological process | ISS[7545544] | |
GO:0034618 | arginine binding | molecular function | TAS[17029414] | |
GO:0098735 | positive regulation of the force of heart contraction | biological process | ISS | |
GO:0007565 | female pregnancy | biological process | IEA | |
GO:0004517 | nitric-oxide synthase activity | molecular function | IDA[1689048]; ISS[7545544] | |
GO:0055114 | oxidation-reduction process | biological process | IEA | |
GO:0020037 | heme binding | molecular function | ISS | |
GO:0048471 | perinuclear region of cytoplasm | cellular component | ISS[17027776] | |
GO:0032496 | response to lipopolysaccharide | biological process | IEA | |
GO:0045776 | negative regulation of blood pressure | biological process | IBA | |
GO:0007568 | aging | biological process | IEA | |
GO:0045121 | membrane raft | cellular component | ISS | |
GO:0012506 | vesicle membrane | cellular component | IEA | |
GO:0005739 | mitochondrion | cellular component | ISS | |
GO:0045202 | synapse | cellular component | ISS | |
GO:0017080 | sodium channel regulator activity | molecular function | ISS | |
GO:0018119 | peptidyl-cysteine S-nitrosylation | biological process | ISS | |
GO:1902307 | positive regulation of sodium ion transmembrane transport | biological process | ISS | |
GO:0033555 | multicellular organismal response to stress | biological process | IMP[18391107] | |
GO:0042383 | sarcolemma | cellular component | IDA[7545544] | |
GO:0031965 | nuclear membrane | cellular component | IEA | |
GO:0010181 | FMN binding | molecular function | ISS | |
GO:0005829 | cytosol | cellular component | TAS | |
GO:0043434 | response to peptide hormone | biological process | IEA | |
GO:0034617 | tetrahydrobiopterin binding | molecular function | NAS[7488039] | |
GO:0071260 | cellular response to mechanical stimulus | biological process | IEA | |
GO:0045822 | negative regulation of heart contraction | biological process | IEA | |
GO:0071363 | cellular response to growth factor stimulus | biological process | ISS | |
GO:0045893 | positive regulation of transcription, DNA-templated | biological process | ISS | |
GO:0051926 | negative regulation of calcium ion transport | biological process | ISS | |
GO:0001666 | response to hypoxia | biological process | IEP[16276418] | |
GO:0042738 | exogenous drug catabolic process | biological process | ISS | |
GO:0045454 | cell redox homeostasis | biological process | TAS | |
GO:0005741 | mitochondrial outer membrane | cellular component | IEA | |
GO:1903779 | regulation of cardiac conduction | biological process | TAS | |
GO:0002028 | regulation of sodium ion transport | biological process | ISS | |
GO:0043066 | negative regulation of apoptotic process | biological process | IEA | |
GO:0043627 | response to estrogen | biological process | IEA | |
GO:0005506 | iron ion binding | molecular function | IEA | |
GO:0007263 | nitric oxide mediated signal transduction | biological process | IBA | |
GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | biological process | ISS | |
GO:0043267 | negative regulation of potassium ion transport | biological process | ISS | |
GO:0097110 | scaffold protein binding | molecular function | ISS | |
GO:1902514 | regulation of generation of L-type calcium current | biological process | TAS[21536106] | |
GO:0019899 | enzyme binding | molecular function | IEA | |
GO:0014823 | response to activity | biological process | IEA | |
GO:0051612 | negative regulation of serotonin uptake | biological process | ISS | |
GO:0031284 | positive regulation of guanylate cyclase activity | biological process | IBA | |
GO:0008285 | negative regulation of cell proliferation | biological process | IEA | |
GO:0050660 | flavin adenine dinucleotide binding | molecular function | ISS | |
GO:0050661 | NADP binding | molecular function | ISS | |
GO:0051481 | negative regulation of cytosolic calcium ion concentration | biological process | IEA | |
GO:0042136 | neurotransmitter biosynthetic process | biological process | TAS[7545544] | |
GO:0006941 | striated muscle contraction | biological process | ISS | |
GO:1990425 | ryanodine receptor complex | cellular component | TAS[21536106] | |
GO:1901205 | negative regulation of adrenergic receptor signaling pathway involved in heart process | biological process | TAS[21536106] | |
GO:0046870 | cadmium ion binding | molecular function | ISS |
Literature-origin KEGG pathway | ||||
ID | Name | Brief Description | Full Description | |
---|---|---|---|---|
hsa04730 | long term_depression | Long-term depression | Cerebellar long-term depression (LTD), thought to be a molec...... Cerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar learning, is a process involving a decrease in the synaptic strength between parallel fiber (PF) and Purkinje cells (PCs) induced by the conjunctive activation of PFs and climbing fiber (CF). Multiple signal transduction pathways have been shown to be involved in this process. Activation of PFs terminating on spines in dendritic branchlets leads to glutamate release and activation of both AMPA and mGluRs. Activation of CFs, which make multiple synaptic contacts on proximal dendrites, also via AMPA receptors, opens voltage-gated calcium channels (VGCCs) and causes a generalized influx of calcium. These cellular signals, generated from two different synaptic origins, trigger a cascade of events culminating in a phosphorylation-dependent, long-term reduction in AMPA receptor sensitivity at the PF-PC synapse. This may take place either through receptor internalization and/or through receptor desensitization. More... | |
hsa04020 | calcium signaling_pathway | Calcium signaling pathway | Ca2+ that enters the cell from the outside is a principal so...... Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs). The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it. The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM). More... |
Gene mapped KEGG pathways | ||||
ID | Name | Brief Description | Full Description | |
---|---|---|---|---|
hsa05010 | alzheimers disease | Alzheimer's disease | Alzheimer's disease (AD) is a chronic disorder that slowly d...... Alzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. The extracellular Abeta oligomers may activate caspases through activation of cell surface death receptors. Alternatively, intracellular Abeta may contribute to pathology by facilitating tau hyper-phosphorylation, disrupting mitochondria function, and triggering calcium dysfunction. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specifically the more amyloidogenic form, Abeta42. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress. More... | |
hsa05014 | amyotrophic lateral_sclerosis_als | Amyotrophic lateral sclerosis (ALS) | Amyotrophic lateral sclerosis (ALS) is a progressive, lethal...... Amyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord, leading to paralysis of voluntary muscles. Mutant superoxide dismutase 1 (SOD1), as seen in some familial amyotrophic lateral sclerosis (FALS) cases, may be toxic because it is unstable, forming aggregates in the motor neuron cytoplasm, axoplasm and mitochondria. Within mitochondria, mutant SOD1 may interfere with the anti-apoptotic function of Bcl-2, affect mitochondrial import by interfering with the translocation machinery (TOM/TIM), and generate toxic free radicals (ROS) via aberrant superoxide chemistry. These changes may then result in abnormal mitochondrial energy metabolism, Ca2+ handling, and release of pro-apoptotic factors. Reactive oxygen species (ROS), produced within mitochondria, inhibit the function of EAAT2, the main glial glutamate transporter protein, responsible for most of the reuptake of synaptically released glutamate. Glutamate excess causes neurotoxicity by increasing intracellular calcium, which enhances oxidative stress and mitochondrial damage. Mutant SOD1 can also trigger oxidative reactions by various means including by increasing levels of peroxynitrite, which can then cause damage through the formation of hydroxyl radicals or via nitration of tyrosine residues on proteins. Nitration may target neurofilament proteins, disrupting their phosphorylation and affecting axonal transport. Collectively, these mechanisms (or a combination thereof) are predicted to disturb cellular homeostasis (within glial and/or motor neurons), ultimately triggering motor neuron death. More... | |
hsa00330 | arginine and_proline_metabolism | Arginine and proline metabolism |
Gene mapped BioCarta pathways | ||||
ID | Name | Brief Description | Full Description | |
---|---|---|---|---|
NOS1_PATHWAY | nos1 pathway | Nitric Oxide Signaling Pathway | Glutamatergic-mediated nitric oxide (NO) production occurs v...... Glutamatergic-mediated nitric oxide (NO) production occurs via the N-methyl-D-aspartic acid (NMDA) postsynaptic density protein 95 (PSD95)-neuronal nitric oxide synthase (NOS1) ternary complex. The increased intracellular Ca2+ stimulates the interaction of nNOS and calmodulin (CaM) and the translocaton of nNOS from the plasma membrane to the cytoplasm. The dephosphorylation of nNOS by Calcineurin catalyzes the conversion of arginine to citrulline and nitric oxide (NO), which turns on guanylate cyclase and the various cGMP regulated signaling pathways. More... |

Gene | Interactor | Interactor in MK4MDD? | Experiment Type | PMID | |
---|---|---|---|---|---|
NOS1 | CAMK4 | No | in vitro | 10400690 , 10874031 , 12630910 , 1375933 | |
NOS1 | HSP90AA1 | No | in vitro;in vivo | 11284722 , 9880522 | |
NOS1 | PFKM | No | in vitro | 10187848 | |
NOS1 | PRKACA | No | in vitro | 10400690 , 10874031 , 12630910 , 1375933 | |
NOS1 | CAMK2A | Yes | in vitro | 10400690 , 10874031 , 12630910 , 1375933 | |
NOS1 | ZDHHC23 | No | in vitro;in vivo | 15105416 | |
NOS1 | CAMK1 | No | in vitro;in vivo | 10400690 , 10874031 , 12630910 , 1375933 , 15251453 | |
NOS1 | ARG1 | No | in vivo | 11849441 | |
NOS1 | CTBP1 | No | in vitro;in vivo | 11590170 | |
NOS1 | ADRB1 | No | in vivo | 12184796 | |
NOS1 | DLG4 | Yes | in vitro;in vivo;yeast 2-hybrid | 8625413 , 10488080 , 9459447 | |
NOS1 | DYNLL1 | No | in vitro;in vivo;yeast 2-hybrid | 8864115 , 9837926 , 9808772 | |
NOS1 | CAV3 | No | in vitro | 9353265 | |
NOS1 | DLGAP2 | No | in vitro | 10824095 | |
NOS1 | BDKRB2 | No | in vivo | 10681501 | |
NOS1 | RASD1 | No | in vivo | 11086993 | |
NOS1 | PTPRN | No | in vitro;in vivo | 11043403 | |
NOS1 | SNTA1 | No | in vitro;in vivo | 11747091 , 10221915 | |
NOS1 | ADRA1A | No | in vivo | 12184796 | |
NOS1 | ATP2B4 | No | in vitro;in vivo | 11591728 | |
NOS1 | ADRA1B | No | in vivo | 12184796 | |
NOS1 | NOS1AP | No | in vitro;in vivo;yeast 2-hybrid | 9459447 | |
NOS1 | NOSIP | Yes | in vivo | 15548660 | |
NOS1 | PTPN6 | Yes | in vitro;in vivo | 11511520 | |
NOS1 | PRKCA | No | in vitro | 10400690 , 10874031 , 12630910 , 1375933 | |
NOS1 | VAC14 | No | in vitro;in vivo | 17161399 | |
NOS1 | ADRB2 | Yes | in vivo | 12184796 | |
NOS1 | ADRA1D | No | in vivo | 12184796 | |
NOS1 | DLG2 | Yes | in vitro;yeast 2-hybrid | 8625413 , 8922396 | |
NOS1 | HMOX1 | No | in vivo | 11849436 |