Gene Report

Basic Information

Approved Symbol	CLOCK
Approved Name	clock circadian regulator
Previous Name	clock (mouse) homolog, "clock homolog (mouse)"
Symbol Alias	KIAA0334, KAT13D, bHLHe8
Location	4q12
Position	chr4:56294068-56413076 (-)
External Links	Entrez Gene: 9575 Ensembl: ENSG00000134852 UCSC: uc003hba.1 HGNC ID: 2082
No. of Studies (Positive/Negative)	2(0/2)
Type	Literature-origin

Positive relationships between CLOCK and MDD (count: 0)

Positive relationships between CLOCK and other components at different levels (count: 0)

Positive relationship network of CLOCK in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between CLOCK and MDD (count: 2)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
CLOCK	Kishi T, 2009	Patients and nomal controls		No significant association was found with BP and MDD No significant association was found with BP and MDD
CLOCK	Kishi T, 2011	Patients and nomal controls	p=0.211	We did not detect any associations between tagging SNPs in ...... We did not detect any associations between tagging SNPs in CLOCK and BP or MDD in the allele, genotype, or haplotype analysis (global p(BP)=.605 and global p(MDD)=.211) More...

Negative relationships between CLOCK and other components at different levels (count: 0)

CLOCK related SNPs in MK4MDD (count: 0)

CLOCK related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Circadian locomoter output cycles protein kaput	O15516	0(0/0)	Gene mapped

CLOCK related GO terms (count: 23)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0043231	intracellular membrane-bounded organelle	cellular component	IDA
GO:0070888	E-box binding	molecular function	IDA[18411297]
GO:0004871	signal transducer activity	molecular function	IEA
GO:0000077	DNA damage checkpoint	biological process	IMP
GO:0032922	circadian regulation of gene expression	biological process	ISS
GO:0006355	regulation of transcription, DNA-dependent	biological process	ISS
GO:0007623	circadian rhythm	biological process	TAS[10198158]
GO:0009648	photoperiodism	biological process	TAS[10198158]
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular function	ISS
GO:0005634	nucleus	cellular component	IDA
GO:0005667	transcription factor complex	cellular component	IPI[9576906]
GO:0071479	cellular response to ionizing radiation	biological process	IDA
GO:0005694	chromosome	cellular component	IDA
GO:0005829	cytosol	cellular component	TAS
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	molecular function	IDA[18411297]
GO:0007165	signal transduction	biological process	TAS[10198158]
GO:0004402	histone acetyltransferase activity	molecular function	IEA
GO:0001190	RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription	molecular function	ISS
GO:0000982	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity	molecular function	ISS
GO:0006357	regulation of transcription from RNA polymerase II promoter	biological process	TAS[10198158]
GO:0005730	nucleolus	cellular component	IDA
GO:0046983	protein dimerization activity	molecular function	IEA
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IGI[9576906]

CLOCK related KEGG pathways (count: 1)

Gene mapped KEGG pathways
ID	Name	Brief Description	Full Description
hsa04710	circadian rhythm_mammal	Circadian rhythm - mammal

CLOCK related BioCarta pathways (count: 0)

CLOCK related Reactome pathways (count: 0)

CLOCK related interactors from protein-protein interaction data in HPRD (count: 3)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
CLOCK	ARNTL2	No	in vitro;in vivo	10864977 , 11018023
CLOCK	PER3	No	in vivo	14701732
CLOCK	ARNTL	No	in vivo	9989497

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways