MK4MDD

Gene Report

Basic Information
Approved Symbol CLOCK
Approved Name clock circadian regulator
Previous Name "clock (mouse) homolog", "clock homolog (mouse)"
Symbol Alias KIAA0334, KAT13D, bHLHe8
Location 4q12
Position chr4:56412949-56413076 (-)
External Links Entrez Gene: 9575
Ensembl: ENSG00000134852
UCSC: uc003hba.2
HGNC ID: 2082
No. of Studies (Positive/Negative) 4(0/4) Help
Type Literature-origin

Positive relationships between CLOCK and MDD (count: 0)
Positive relationships between CLOCK and other components at different levels (count: 0) Help
Positive relationship network of CLOCK in MK4MDD
Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between CLOCK and MDD (count: 4)
Name in Literature Reference Research Type Statistical Result Relation Description
CLOCK Kishi T, 2009 Patients and nomal controls No significant association was found with BP and MDD No significant association was found with BP and MDD
CLOCK Kishi T, 2011 Patients and nomal controls p=0.211 We did not detect any associations between tagging SNPs in ...... We did not detect any associations between tagging SNPs in CLOCK and BP or MDD in the allele, genotype, or haplotype analysis (global p(BP)=.605 and global p(MDD)=.211) More...
CLOCK Crisafulli C, 2013 patients and normal controls No association with mood disorders and clinical outcomes was...... No association with mood disorders and clinical outcomes was observed More...
CLOCK Byrne EM, 2014 Patients and nomal controls P-Values=0.54 These results show that while there are several circadian ge...... These results show that while there are several circadian genes that harbor SNPs with nominally significant P-values, there are no associations beyond what would be expected after controlling for the number of SNPs in each gene. The gene-based test not only controls for the number of SNPs, but also combines evidence from multiple SNPs after controlling for the linkage disequilibrium between them More...

Negative relationships between CLOCK and other components at different levels (count: 0) Help
CLOCK related SNPs in MK4MDD (count: 0)
CLOCK related proteins in MK4MDD (count: 0)
CLOCK related GO terms (count: 43)
CLOCK related KEGG pathways (count: 1)
CLOCK related BioCarta pathways (count: 0)
CLOCK related Reactome pathways (count: 0)
CLOCK related interactors from protein-protein interaction data in HPRD (count: 3)