Gene Report

Basic Information

Approved Symbol	CLOCK
Approved Name	clock circadian regulator
Previous Name	"clock (mouse) homolog", "clock homolog (mouse)"
Symbol Alias	KIAA0334, KAT13D, bHLHe8
Location	4q12
Position	chr4:56412949-56413076 (-)
External Links	Entrez Gene: 9575 Ensembl: ENSG00000134852 UCSC: uc003hba.2 HGNC ID: 2082
No. of Studies (Positive/Negative)	4(0/4)
Type	Literature-origin

Positive relationships between CLOCK and MDD (count: 0)

Positive relationships between CLOCK and other components at different levels (count: 0)

Positive relationship network of CLOCK in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between CLOCK and MDD (count: 4)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
CLOCK	Kishi T, 2009	Patients and nomal controls		No significant association was found with BP and MDD No significant association was found with BP and MDD
CLOCK	Kishi T, 2011	Patients and nomal controls	p=0.211	We did not detect any associations between tagging SNPs in ...... We did not detect any associations between tagging SNPs in CLOCK and BP or MDD in the allele, genotype, or haplotype analysis (global p(BP)=.605 and global p(MDD)=.211) More...
CLOCK	Crisafulli C, 2013	patients and normal controls		No association with mood disorders and clinical outcomes was...... No association with mood disorders and clinical outcomes was observed More...
CLOCK	Byrne EM, 2014	Patients and nomal controls	P-Values=0.54	These results show that while there are several circadian ge...... These results show that while there are several circadian genes that harbor SNPs with nominally significant P-values, there are no associations beyond what would be expected after controlling for the number of SNPs in each gene. The gene-based test not only controls for the number of SNPs, but also combines evidence from multiple SNPs after controlling for the linkage disequilibrium between them More...

Negative relationships between CLOCK and other components at different levels (count: 0)

CLOCK related SNPs in MK4MDD (count: 0)

CLOCK related proteins in MK4MDD (count: 0)

CLOCK related GO terms (count: 43)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0046983	protein dimerization activity	molecular function	IEA
GO:0003700	transcription factor activity, sequence-specific DNA binding	molecular function	ISS
GO:0001047	core promoter binding	molecular function	ISS
GO:0051092	positive regulation of NF-kappaB transcription factor activity	biological process	ISS
GO:0006325	chromatin organization	biological process	TAS
GO:0005634	nucleus	cellular component	IDA[14645221]
GO:0005654	nucleoplasm	cellular component	IDA; TAS
GO:0016573	histone acetylation	biological process	IEA; IMP[21980503]
GO:0000982	transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding	molecular function	ISS
GO:0007623	circadian rhythm	biological process	TAS
GO:0071479	cellular response to ionizing radiation	biological process	IDA[21659603]
GO:0000077	DNA damage checkpoint	biological process	IMP[21659603]
GO:0001046	core promoter sequence-specific DNA binding	molecular function	IEA
GO:0045893	positive regulation of transcription, DNA-templated	biological process	IDA[23785138]; ISS
GO:0005667	transcription factor complex	cellular component	IPI[9576906]
GO:0007165	signal transduction	biological process	TAS[10198158]
GO:0004402	histone acetyltransferase activity	molecular function	IMP[21980503]
GO:0043565	sequence-specific DNA binding	molecular function	ISS
GO:0006357	regulation of transcription from RNA polymerase II promoter	biological process	TAS[10198158]
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	molecular function	IDA[18411297]
GO:0006366	transcription from RNA polymerase II promoter	biological process	IEA; ISS
GO:0032922	circadian regulation of gene expression	biological process	IDA[24005054]; IMP[21980503]; ISS
GO:0006355	regulation of transcription, DNA-templated	biological process	ISS
GO:0043231	intracellular membrane-bounded organelle	cellular component	IDA
GO:0051775	response to redox state	biological process	IDA[11441146]
GO:0050796	regulation of insulin secretion	biological process	ISS
GO:0070888	E-box binding	molecular function	IDA[18411297\|23785138]
GO:0009649	entrainment of circadian clock	biological process	IEA
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IGI[9576906]
GO:0031490	chromatin DNA binding	molecular function	ISS
GO:0005694	chromosome	cellular component	IDA[21659603]
GO:0007283	spermatogenesis	biological process	ISS
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	biological process	ISS
GO:0003677	DNA binding	molecular function	IDA[11441146]
GO:0042634	regulation of hair cycle	biological process	IMP[24005054]
GO:2000074	regulation of type B pancreatic cell development	biological process	ISS
GO:0005515	protein binding	molecular function	IPI[14645221\|20861012\|21960634\|21980503]
GO:0009648	photoperiodism	biological process	TAS[10198158]
GO:0033391	chromatoid body	cellular component	ISS
GO:2000323	negative regulation of glucocorticoid receptor signaling pathway	biological process	ISS
GO:0050729	positive regulation of inflammatory response	biological process	IEA
GO:0001190	transcriptional activator activity, RNA polymerase II transcription factor binding	molecular function	ISS
GO:0045892	negative regulation of transcription, DNA-templated	biological process	ISS

CLOCK related KEGG pathways (count: 1)

Gene mapped KEGG pathways
ID	Name	Brief Description	Full Description
hsa04710	circadian rhythm_mammal	Circadian rhythm - mammal

CLOCK related BioCarta pathways (count: 0)

CLOCK related Reactome pathways (count: 0)

CLOCK related interactors from protein-protein interaction data in HPRD (count: 3)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
CLOCK	ARNTL2	Yes	in vitro;in vivo	10864977 , 11018023
CLOCK	PER3	Yes	in vivo	14701732
CLOCK	ARNTL	Yes	in vivo	9989497

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways