Gene Report

Basic Information

Approved Symbol	GDNF
Approved Name	glial cell derived neurotrophic factor
Symbol Alias	ATF1, ATF2, HFB1-GDNF
Name Alias	"astrocyte-derived trophic factor", "glial cell line derived neurotrophic factor", "glial derived neurotrophic factor"
Location	5p13.1-p12
Position	chr5:37839609-37839782 (-)
External Links	Entrez Gene: 2668 Ensembl: ENSG00000168621 UCSC: uc011cpg.2 HGNC ID: 4232
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin; Protein mapped

Positive relationships between GDNF and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
GDNF	Otsuki, 2008	patients and normal controls		Reduced expression levels of GDNF, ARTN, and NT-3 mRNAs were...... Reduced expression levels of GDNF, ARTN, and NT-3 mRNAs were found in patients with major depressive disorder in a current depressive state More...

Positive relationships between GDNF and other components at different levels (count: 0)

Positive relationship network of GDNF in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between GDNF and MDD (count: 0)

Negative relationships between GDNF and other components at different levels (count: 0)

GDNF related SNPs in MK4MDD (count: 0)

GDNF related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Glial cell line-derived neurotrophic factor	P39905	1(1/0)	Literature-origin

GDNF related GO terms (count: 37)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0033603	positive regulation of dopamine secretion	biological process	TAS[12358785]
GO:0048484	enteric nervous system development	biological process	ISS
GO:0032770	positive regulation of monooxygenase activity	biological process	IDA[12358785]
GO:0005576	extracellular region	cellular component	IDA[9811930]
GO:0007165	signal transduction	biological process	TAS[7830769]
GO:0045597	positive regulation of cell differentiation	biological process	IGI[22897442]
GO:0003337	mesenchymal to epithelial transition involved in metanephros morphogenesis	biological process	IEA
GO:0021784	postganglionic parasympathetic fiber development	biological process	ISS
GO:0010468	regulation of gene expression	biological process	IGI[22897442]
GO:0001656	metanephros development	biological process	ISS
GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	biological process	IDA[8657307\|17229286]
GO:0001941	postsynaptic membrane organization	biological process	IEA
GO:2000736	regulation of stem cell differentiation	biological process	TAS[23626767]
GO:0005515	protein binding	molecular function	IPI[25416956]
GO:0048255	mRNA stabilization	biological process	IDA[12358785]
GO:0060676	ureteric bud formation	biological process	IEA
GO:0031175	neuron projection development	biological process	IDA[15242795]
GO:0060688	regulation of morphogenesis of a branching structure	biological process	ISS
GO:0001755	neural crest cell migration	biological process	IDA[15242795]
GO:0043066	negative regulation of apoptotic process	biological process	TAS[7830769]
GO:0051584	regulation of dopamine uptake involved in synaptic transmission	biological process	IDA[8493557]
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	biological process	IDA[10921886]
GO:0048485	sympathetic nervous system development	biological process	ISS
GO:0072108	positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	biological process	IEA
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IDA[12358785]
GO:0072107	positive regulation of ureteric bud formation	biological process	IDA[8657307]
GO:0030432	peristalsis	biological process	ISS
GO:0001658	branching involved in ureteric bud morphogenesis	biological process	ISS
GO:0043524	negative regulation of neuron apoptotic process	biological process	IDA[8493557]
GO:0008344	adult locomotory behavior	biological process	TAS[12358785]
GO:0008284	positive regulation of cell proliferation	biological process	IDA[22897442]
GO:0042803	protein homodimerization activity	molecular function	IDA[8493557\|8988018]
GO:0001759	organ induction	biological process	IEA
GO:0005102	receptor binding	molecular function	TAS[10829012]
GO:0007399	nervous system development	biological process	TAS[8637574]
GO:0007411	axon guidance	biological process	TAS
GO:0008083	growth factor activity	molecular function	IEA

GDNF related KEGG pathways (count: 0)

GDNF related BioCarta pathways (count: 0)

GDNF related Reactome pathways (count: 3)

ID	Name	Description
Gene mapped Reactome pathways
REACT_18334	ncam signaling_for_neurite_out_growth	The neural cell adhesion molecule, NCAM, is a member of the ...... The neural cell adhesion molecule, NCAM, is a member of the immunoglobulin (Ig) superfamily and is involved in a variety of cellular processes of importance for the formation and maintenance of the nervous system. The role of NCAM in neural differentiation and synaptic plasticity is presumed to depend on the modulation of intracellular signal transduction cascades. NCAM based signaling complexes can initiate downstream intracellular signals by at least two mechanisms: (1) activation of FGFR and (2) formation of intracellular signaling complexes by direct interaction with cytoplasmic interaction partners such as Fyn and FAK. Tyrosine kinases Fyn and FAK interact with NCAM and undergo phosphorylation and this transiently activates the MAPK, ERK 1 and 2, cAMP response element binding protein (CREB) and transcription factors ELK and NFkB. CREB activates transcription of genes which are important for axonal growth, survival, and synaptic plasticity in neurons. NCAM1 mediated intracellular signal transduction is represented in the figure below. The Ig domains in NCAM1 are represented in orange ovals and Fn domains in green squares. The tyrosine residues susceptible to phosphorylation are represented in red circles and their positions are numbered. Phosphorylation is represented by red arrows and dephosphorylation by yellow. Ig, Immunoglobulin domain; Fn, Fibronectin domain; Fyn, Proto-oncogene tyrosine-protein kinase Fyn; FAK, focal adhesion kinase; RPTPalpha, Receptor-type tyrosine-protein phosphatase; Grb2, Growth factor receptor-bound protein 2; SOS, Son of sevenless homolog; Raf, RAF proto-oncogene serine/threonine-protein kinase; MEK, MAPK and ERK kinase; ERK, Extracellular signal-regulated kinase; MSK1, Mitogen and stress activated protein kinase 1; CREB, Cyclic AMP-responsive element-binding protein; CRE, cAMP response elements. More...
REACT_18266	axon guidance	Axon guidance / axon pathfinding is the process by which neu...... Axon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, which senses the guidance cues in the environment through guidance cue receptors and responds by undergoing cytoskeletal changes that determine the direction of axon growth. Guidance cues present in the surrounding environment provide the necessary directional information for the trip. These extrinsic cues have been divided into attractive or repulsive signals that tell the growth cone where and where not to grow. Genetic and biochemical studies have led to the identification of highly conserved families of guidance molecules and their receptors that guide axons. These include netrins, Slits, semaphorins, and ephrins, and their cognate receptors, DCC and or uncoordinated-5 (UNC5), roundabouts (Robo), neuropilin and Eph. In addition, many other classes of adhesion molecules are also used by growth cones to navigate properly which include NCAM and L1CAM. More...
REACT_18312	ncam1 interactions	The neural cell adhesion molecule, NCAM1 is generally consid...... The neural cell adhesion molecule, NCAM1 is generally considered as a cell adhesion mediator, but it is also considered to be a signal transducing receptor molecule. NCAM1 is involved in multiple cis- and trans-homophilic interactions. It is also involved in several heterophilic interactions with a broad range of other molecules, thereby modulating diverse biological phenomena including cellular adhesion, migration, proliferation, differentiation, survival and synaptic plasticity. More...

GDNF related interactors from protein-protein interaction data in HPRD (count: 5)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
GDNF	GDNF	Yes	in vitro	11842239
GDNF	GFRA2	No	in vitro	9407096
GDNF	RET	No	in vitro	8674117
GDNF	GFRA1	No	in vitro;in vivo	8674117 , 9482105
GDNF	NCAM1	Yes	in vivo	12837245

Gene Report

Gene mapped GO terms

Gene mapped Reactome pathways