Gene Report

Basic Information

Approved Symbol	SDC4
Approved Name	syndecan 4
Previous Name	syndecan 4 (amphiglycan, ryudocan)
Symbol Alias	SYND4, amphiglycan, ryudocan
Name Alias	syndecan proteoglycan 4
Location	20q12
Position	chr20:43953928-43977064 (-)
External Links	Entrez Gene: 6385 Ensembl: ENSG00000124145 UCSC: uc002xnu.3 HGNC ID: 10661
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between SDC4 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
SDC4	Guilloux JP, 2012	patients and normal controls		genes significantly affected in female MDD subjects genes significantly affected in female MDD subjects

Positive relationships between SDC4 and other components at different levels (count: 0)

Positive relationship network of SDC4 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between SDC4 and MDD (count: 0)

Negative relationships between SDC4 and other components at different levels (count: 0)

SDC4 related SNPs in MK4MDD (count: 0)

SDC4 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Syndecan-4	P31431	0(0/0)	Gene mapped

SDC4 related GO terms (count: 25)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005796	Golgi lumen	cellular component	TAS
GO:0070053	thrombospondin receptor activity	molecular function	IMP[17879962]
GO:0045121	membrane raft	cellular component	IEA
GO:0043202	lysosomal lumen	cellular component	TAS
GO:0009986	cell surface	cellular component	IEA
GO:0001968	fibronectin binding	molecular function	IEA
GO:0044281	small molecule metabolic process	biological process	TAS
GO:0005975	carbohydrate metabolic process	biological process	TAS
GO:0051894	positive regulation of focal adhesion assembly	biological process	IEA
GO:0008092	cytoskeletal protein binding	molecular function	IEA
GO:0008150	biological_process	biological process	ND
GO:0005515	protein binding	molecular function	IPI[12571249]
GO:0005887	integral to plasma membrane	cellular component	NAS[1500433]
GO:0005576	extracellular region	cellular component	IEA
GO:0030204	chondroitin sulfate metabolic process	biological process	TAS
GO:0045860	positive regulation of protein kinase activity	biological process	IEA
GO:0006027	glycosaminoglycan catabolic process	biological process	TAS
GO:0005925	focal adhesion	cellular component	IEA
GO:0051496	positive regulation of stress fiber assembly	biological process	IEA
GO:0043034	costamere	cellular component	IEA
GO:0030203	glycosaminoglycan metabolic process	biological process	TAS
GO:0001657	ureteric bud development	biological process	IEA
GO:0006024	glycosaminoglycan biosynthetic process	biological process	TAS
GO:0005886	plasma membrane	cellular component	TAS
GO:0005080	protein kinase C binding	molecular function	IEA

SDC4 related KEGG pathways (count: 2)

ID	Name	Brief Description	Full Description
Literature-origin KEGG pathway
hsa04514	cell adhesion_molecules_cams	Cell adhesion molecules (CAMs)	Cell adhesion molecules are (glyco)proteins expressed on the...... Cell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cellcell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes. More...
hsa04512	ecm receptor_interaction	ECM-receptor interaction	The extracellular matrix (ECM) consists of a complex mixture...... The extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell and tissue structure and function. Specific interactions between cells and the ECM are mediated by transmembrane molecules, mainly integrins and perhaps also proteoglycans, CD36, or other cell-surface-associated components. These interactions lead to a direct or indirect control of cellular activities such as adhesion, migration, differentiation, proliferation, and apoptosis. In addition, integrins function as mechanoreceptors and provide a force-transmitting physical link between the ECM and the cytoskeleton. Integrins are a family of glycosylated, heterodimeric transmembrane adhesion receptors that consist of noncovalently bound alpha- and beta-subunits. More...

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways

SDC4 related BioCarta pathways (count: 0)

SDC4 related Reactome pathways (count: 0)

SDC4 related interactors from protein-protein interaction data in HPRD (count: 11)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
SDC4	CXCR4	No	in vivo	15819887
SDC4	SDCBP	No	in vivo	12241528
SDC4	PRKCA	No	in vitro	11916978 , 9556568 , 14670076
SDC4	PRKCD	No	in vitro;in vivo	11916978
SDC4	MDK	No	in vitro	8621465
SDC4	CASK	No	in vitro;yeast 2-hybrid	9660868
SDC4	TGFB1I1	No	in vitro	11805099
SDC4	SDC4	Yes	in vitro	11456484 , 9582338
SDC4	GIPC1	No	in vitro;in vivo;yeast 2-hybrid	10911369
SDC4	CCL5	No	in vivo	14637022
SDC4	PXN	No	in vitro	11805099

Gene Report

Gene mapped GO terms

Literature-origin KEGG pathway

Gene mapped KEGG pathways