
Gene Report
Approved Symbol | NPM1 |
---|---|
Approved Name | nucleophosmin (nucleolar phosphoprotein B23, numatrin) |
Symbol Alias | B23, NPM |
Name Alias | "nucleolar phosphoprotein B23", "numatrin", "nucleophosmin/nucleoplasmin family, member 1" |
Location | 5q35.1 |
Position | chr5:170837570-170837888 (+) |
External Links |
Entrez Gene: 4869 Ensembl: ENSG00000181163 UCSC: uc003mbi.3 HGNC ID: 7910 |
No. of Studies (Positive/Negative) | 1(0/1)
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Type | Literature-origin |
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus | Protein and Other Molecule | Cell and Molecular Pathway | Neural System | Cognition and Behavior | Symptoms and Signs | Environment | MDD |
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2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Name in Literature | Reference | Research Type | Statistical Result | Relation Description |
---|---|---|---|---|
NPM1 | Wray, 2010 | patients and normal controls | Top ten ranked genes from gene-based test for genes +/-50 kb...... Top ten ranked genes from gene-based test for genes +/-50 kb from start and stop positions More... |
Literature-origin GO terms | ||||
ID | Name | Type | Evidence | |
---|---|---|---|---|
GO:0006950 | response to stress | biological process | IMP[12080348] |
Gene mapped GO terms | ||||
ID | Name | Type | Evidence | |
---|---|---|---|---|
GO:0051059 | NF-kappaB binding | molecular function | IDA[15087454]; ISS | |
GO:0042393 | histone binding | molecular function | IDA[11602260] | |
GO:0005813 | centrosome | cellular component | IDA[11051553]; ISS | |
GO:0016020 | membrane | cellular component | IDA[19946888] | |
GO:0010826 | negative regulation of centrosome duplication | biological process | IMP[16041368] | |
GO:0030957 | Tat protein binding | molecular function | IDA[9094689] | |
GO:0006913 | nucleocytoplasmic transport | biological process | IDA[16041368]; TAS[12080348] | |
GO:0051259 | protein oligomerization | biological process | IDA[18809582] | |
GO:0005515 | protein binding | molecular function | IPI[12080348|12882984|15144954|15161933|15184379|15989956|16376884|16648475|16957780|17015463|17318229|17438371|17475909|17602943|18259216|18420587|19188445|19410545|20075868|20159986|20618440|21326211|21822216|22510990|22528486|22712502|22720776|23019224 | |
GO:0008285 | negative regulation of cell proliferation | biological process | IMP[12080348]; ISS | |
GO:0046982 | protein heterodimerization activity | molecular function | IMP[12080348] | |
GO:0030529 | intracellular ribonucleoprotein complex | cellular component | IDA[18809582] | |
GO:0006886 | intracellular protein transport | biological process | TAS[12080348] | |
GO:1904030 | negative regulation of cyclin-dependent protein kinase activity | biological process | IDA[12882984] | |
GO:0032071 | regulation of endodeoxyribonuclease activity | biological process | IDA[19188445] | |
GO:0007569 | cell aging | biological process | IMP[12080348]; ISS | |
GO:0045727 | positive regulation of translation | biological process | IDA[12882984] | |
GO:0051082 | unfolded protein binding | molecular function | IDA[10211837]; ISS | |
GO:0008284 | positive regulation of cell proliferation | biological process | IDA[22528486] | |
GO:0043024 | ribosomal small subunit binding | molecular function | IDA[18809582] | |
GO:0043066 | negative regulation of apoptotic process | biological process | IDA[12882984]; NAS[16130169] | |
GO:0008104 | protein localization | biological process | IDA[18420587] | |
GO:0005737 | cytoplasm | cellular component | IDA[9121481]; ISS | |
GO:0005925 | focal adhesion | cellular component | IDA[21423176] | |
GO:0003723 | RNA binding | molecular function | IDA[12058066] | |
GO:0045893 | positive regulation of transcription, DNA-templated | biological process | IDA[22528486] | |
GO:0007165 | signal transduction | biological process | NAS[16130169] | |
GO:0006334 | nucleosome assembly | biological process | IDA[11602260]; TAS | |
GO:0042803 | protein homodimerization activity | molecular function | IDA[9121481] | |
GO:0005654 | nucleoplasm | cellular component | IDA[12058066]; TAS | |
GO:0003713 | transcription coactivator activity | molecular function | IDA[15087454] | |
GO:0006281 | DNA repair | biological process | IDA[19188445] | |
GO:0046599 | regulation of centriole replication | biological process | IMP[20352051] | |
GO:0060699 | regulation of endoribonuclease activity | biological process | IDA[19188445] | |
GO:0034080 | CENP-A containing nucleosome assembly | biological process | TAS | |
GO:0043023 | ribosomal large subunit binding | molecular function | IDA[18809582] | |
GO:0044387 | negative regulation of protein kinase activity by regulation of protein phosphorylation | biological process | IDA[12882984] | |
GO:0042255 | ribosome assembly | biological process | TAS[12080348] | |
GO:0004860 | protein kinase inhibitor activity | molecular function | IDA[12882984] | |
GO:0005730 | nucleolus | cellular component | IDA[11420665|12080348|16041368|17475909|18809582|19188445|22528486] | |
GO:0044822 | poly(A) RNA binding | molecular function | IDA[22658674|22681889] | |
GO:0005829 | cytosol | cellular component | TAS | |
GO:0060735 | regulation of eIF2 alpha phosphorylation by dsRNA | biological process | IDA[12882984] | |
GO:0031616 | spindle pole centrosome | cellular component | IDA[16041368] | |
GO:0007098 | centrosome cycle | biological process | IMP[11051553]; ISS | |
GO:0016032 | viral process | biological process | TAS | |
GO:1902751 | positive regulation of cell cycle G2/M phase transition | biological process | IDA[22528486] | |
GO:0005634 | nucleus | cellular component | IDA[12080348|21630459|22720776]; ISS | |
GO:0051092 | positive regulation of NF-kappaB transcription factor activity | biological process | IMP[15087454] | |
GO:0019901 | protein kinase binding | molecular function | IPI[20352051] |
Gene mapped Reactome pathways | |||
ID | Name | Description | |
---|---|---|---|
REACT_6288 | host interactions_of_hiv_factors | Like all viruses, HIV-1 must co-opt the host cell macromolec...... Like all viruses, HIV-1 must co-opt the host cell macromolecular transport and processing machinery. HIV-1 Vpr and Rev proteins play key roles in this co-optation. Efficient HIV-1 replication likewise requires evasion of APOBEC3G-mediated mutagenesis of reverse transcripts, a process mediated by the viral Vif protein. More... | |
REACT_9395 | nuclear import_of_rev_protein | Nuclear import of Rev involves the cellular proteins includi...... Nuclear import of Rev involves the cellular proteins including importin-beta and B23 and is mediated by an arginine-rich nuclear localization signal (NLS) within the RNA binding domain of the Rev protein. The NLS of Rev associates with importin- beta as well as B23 which has been shown to function in the nuclear import of ribosomal proteins. The Rev-importin -B23 complex associates with the nuclear pore through interactions between importin and nucleoporin. Upon entry into the nucleus, Ran-GTP associates with importin resulting in in the disassembly of the importin -Rev-B23 complex and the release of Rev cargo. More... | |
REACT_6185 | hiv infection | The global pandemic of Human Immunodeficiency Virus. HIV-1 a...... The global pandemic of Human Immunodeficiency Virus. HIV-1 and the less common HIV-2 belong to the family of retroviruses. HIV-1 contains a single-stranded RNA genome that is 9 kilobases in length and contains 9 genes that encode 15 different proteins. These proteins are classified as: structural proteins. HIV infection cycle can be divided into two phases: 1. An Early phase consisting of early events occuring after HIV infection of a susceptible target cell and a 2. Late phase comprising the later events in the HIV-infected cell resulting in the assembly of new infectious virions. The section titled HIV lifecycle consists of annotations of events in these two phases. The virus has developed various molecular strategies to suppress the antiviral immune responses. The section titled Host interactions of HIV factors will highlight these complex post-infection processes and the annotations will be released in near future. More... |

Gene | Interactor | Interactor in MK4MDD? | Experiment Type | PMID | |
---|---|---|---|---|---|
NPM1 | SFRS12 | No | in vitro;in vivo;yeast 2-hybrid | 14559993 | |
NPM1 | PARP1 | No | in vitro | 9642267 | |
NPM1 | IRS1 | No | in vitro | 8633037 | |
NPM1 | ALK | No | in vitro;in vivo | 11888936 | |
NPM1 | SENP3 | No | in vitro;in vivo;yeast 2-hybrid | 18259216 | |
NPM1 | MDM2 | No | in vitro;in vivo | 15144954 | |
NPM1 | TFAP2A | No | in vitro;in vivo | 17318229 | |
NPM1 | CDK1 | No | in vitro;in vivo | 12058066 , 11278991 | |
NPM1 | HAND2 | No | yeast 2-hybrid | 11812799 | |
NPM1 | ARF1 | No | in vitro;in vivo | 14636574 , 15684379 | |
NPM1 | PLCG2 | No | in vivo | 9819383 | |
NPM1 | NCL | No | in vitro;in vivo;yeast 2-hybrid | 10503877 , 8620867 | |
NPM1 | GRB2 | No | in vitro | 8633037 | |
NPM1 | EIF2AK2 | No | in vitro;in vivo | 12882984 | |
NPM1 | NOP2 | Yes | in vitro | 8089149 | |
NPM1 | XPO1 | No | in vivo | 16041368 | |
NPM1 | RPGR | No | in vitro;yeast 2-hybrid | 15772089 | |
NPM1 | GADD45A | No | in vitro;yeast 2-hybrid | 15644315 | |
NPM1 | TCERG1 | No | in vitro | 15456888 | |
NPM1 | SHC1 | No | in vitro | 8633037 | |
NPM1 | CDK2 | No | in vitro;in vivo | 11278991 , 16376875 | |
NPM1 | TP53 | No | in vitro;in vivo | 12080348 , 16376884 | |
NPM1 | HIST3H3 | No | in vitro | 11602260 | |
NPM1 | PLK1 | No | in vitro;in vivo | 15190079 |