Gene Report

Basic Information

Approved Symbol	NPM1
Approved Name	nucleophosmin (nucleolar phosphoprotein B23, numatrin)
Symbol Alias	B23, NPM
Name Alias	"nucleolar phosphoprotein B23", "numatrin", "nucleophosmin/nucleoplasmin family, member 1"
Location	5q35.1
Position	chr5:170837570-170837888 (+)
External Links	Entrez Gene: 4869 Ensembl: ENSG00000181163 UCSC: uc003mbi.3 HGNC ID: 7910
No. of Studies (Positive/Negative)	1(0/1)
Type	Literature-origin

Positive relationships between NPM1 and MDD (count: 0)

Positive relationships between NPM1 and other components at different levels (count: 0)

Positive relationship network of NPM1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between NPM1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
NPM1	Wray, 2010	patients and normal controls		Top ten ranked genes from gene-based test for genes +/-50 kb...... Top ten ranked genes from gene-based test for genes +/-50 kb from start and stop positions More...

Negative relationships between NPM1 and other components at different levels (count: 0)

NPM1 related SNPs in MK4MDD (count: 0)

NPM1 related proteins in MK4MDD (count: 0)

NPM1 related GO terms (count: 51)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0006950	response to stress	biological process	IMP[12080348]

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0051059	NF-kappaB binding	molecular function	IDA[15087454]; ISS
GO:0042393	histone binding	molecular function	IDA[11602260]
GO:0005813	centrosome	cellular component	IDA[11051553]; ISS
GO:0016020	membrane	cellular component	IDA[19946888]
GO:0010826	negative regulation of centrosome duplication	biological process	IMP[16041368]
GO:0030957	Tat protein binding	molecular function	IDA[9094689]
GO:0006913	nucleocytoplasmic transport	biological process	IDA[16041368]; TAS[12080348]
GO:0051259	protein oligomerization	biological process	IDA[18809582]
GO:0005515	protein binding	molecular function	IPI[12080348\|12882984\|15144954\|15161933\|15184379\|15989956\|16376884\|16648475\|16957780\|17015463\|17318229\|17438371\|17475909\|17602943\|18259216\|18420587\|19188445\|19410545\|20075868\|20159986\|20618440\|21326211\|21822216\|22510990\|22528486\|22712502\|22720776\|23019224
GO:0008285	negative regulation of cell proliferation	biological process	IMP[12080348]; ISS
GO:0046982	protein heterodimerization activity	molecular function	IMP[12080348]
GO:0030529	intracellular ribonucleoprotein complex	cellular component	IDA[18809582]
GO:0006886	intracellular protein transport	biological process	TAS[12080348]
GO:1904030	negative regulation of cyclin-dependent protein kinase activity	biological process	IDA[12882984]
GO:0032071	regulation of endodeoxyribonuclease activity	biological process	IDA[19188445]
GO:0007569	cell aging	biological process	IMP[12080348]; ISS
GO:0045727	positive regulation of translation	biological process	IDA[12882984]
GO:0051082	unfolded protein binding	molecular function	IDA[10211837]; ISS
GO:0008284	positive regulation of cell proliferation	biological process	IDA[22528486]
GO:0043024	ribosomal small subunit binding	molecular function	IDA[18809582]
GO:0043066	negative regulation of apoptotic process	biological process	IDA[12882984]; NAS[16130169]
GO:0008104	protein localization	biological process	IDA[18420587]
GO:0005737	cytoplasm	cellular component	IDA[9121481]; ISS
GO:0005925	focal adhesion	cellular component	IDA[21423176]
GO:0003723	RNA binding	molecular function	IDA[12058066]
GO:0045893	positive regulation of transcription, DNA-templated	biological process	IDA[22528486]
GO:0007165	signal transduction	biological process	NAS[16130169]
GO:0006334	nucleosome assembly	biological process	IDA[11602260]; TAS
GO:0042803	protein homodimerization activity	molecular function	IDA[9121481]
GO:0005654	nucleoplasm	cellular component	IDA[12058066]; TAS
GO:0003713	transcription coactivator activity	molecular function	IDA[15087454]
GO:0006281	DNA repair	biological process	IDA[19188445]
GO:0046599	regulation of centriole replication	biological process	IMP[20352051]
GO:0060699	regulation of endoribonuclease activity	biological process	IDA[19188445]
GO:0034080	CENP-A containing nucleosome assembly	biological process	TAS
GO:0043023	ribosomal large subunit binding	molecular function	IDA[18809582]
GO:0044387	negative regulation of protein kinase activity by regulation of protein phosphorylation	biological process	IDA[12882984]
GO:0042255	ribosome assembly	biological process	TAS[12080348]
GO:0004860	protein kinase inhibitor activity	molecular function	IDA[12882984]
GO:0005730	nucleolus	cellular component	IDA[11420665\|12080348\|16041368\|17475909\|18809582\|19188445\|22528486]
GO:0044822	poly(A) RNA binding	molecular function	IDA[22658674\|22681889]
GO:0005829	cytosol	cellular component	TAS
GO:0060735	regulation of eIF2 alpha phosphorylation by dsRNA	biological process	IDA[12882984]
GO:0031616	spindle pole centrosome	cellular component	IDA[16041368]
GO:0007098	centrosome cycle	biological process	IMP[11051553]; ISS
GO:0016032	viral process	biological process	TAS
GO:1902751	positive regulation of cell cycle G2/M phase transition	biological process	IDA[22528486]
GO:0005634	nucleus	cellular component	IDA[12080348\|21630459\|22720776]; ISS
GO:0051092	positive regulation of NF-kappaB transcription factor activity	biological process	IMP[15087454]
GO:0019901	protein kinase binding	molecular function	IPI[20352051]

NPM1 related KEGG pathways (count: 0)

NPM1 related BioCarta pathways (count: 0)

NPM1 related Reactome pathways (count: 3)

ID	Name	Description
Gene mapped Reactome pathways
REACT_6288	host interactions_of_hiv_factors	Like all viruses, HIV-1 must co-opt the host cell macromolec...... Like all viruses, HIV-1 must co-opt the host cell macromolecular transport and processing machinery. HIV-1 Vpr and Rev proteins play key roles in this co-optation. Efficient HIV-1 replication likewise requires evasion of APOBEC3G-mediated mutagenesis of reverse transcripts, a process mediated by the viral Vif protein. More...
REACT_9395	nuclear import_of_rev_protein	Nuclear import of Rev involves the cellular proteins includi...... Nuclear import of Rev involves the cellular proteins including importin-beta and B23 and is mediated by an arginine-rich nuclear localization signal (NLS) within the RNA binding domain of the Rev protein. The NLS of Rev associates with importin- beta as well as B23 which has been shown to function in the nuclear import of ribosomal proteins. The Rev-importin -B23 complex associates with the nuclear pore through interactions between importin and nucleoporin. Upon entry into the nucleus, Ran-GTP associates with importin resulting in in the disassembly of the importin -Rev-B23 complex and the release of Rev cargo. More...
REACT_6185	hiv infection	The global pandemic of Human Immunodeficiency Virus. HIV-1 a...... The global pandemic of Human Immunodeficiency Virus. HIV-1 and the less common HIV-2 belong to the family of retroviruses. HIV-1 contains a single-stranded RNA genome that is 9 kilobases in length and contains 9 genes that encode 15 different proteins. These proteins are classified as: structural proteins. HIV infection cycle can be divided into two phases: 1. An Early phase consisting of early events occuring after HIV infection of a susceptible target cell and a 2. Late phase comprising the later events in the HIV-infected cell resulting in the assembly of new infectious virions. The section titled HIV lifecycle consists of annotations of events in these two phases. The virus has developed various molecular strategies to suppress the antiviral immune responses. The section titled Host interactions of HIV factors will highlight these complex post-infection processes and the annotations will be released in near future. More...

NPM1 related interactors from protein-protein interaction data in HPRD (count: 24)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
NPM1	SFRS12	No	in vitro;in vivo;yeast 2-hybrid	14559993
NPM1	PARP1	No	in vitro	9642267
NPM1	IRS1	No	in vitro	8633037
NPM1	ALK	No	in vitro;in vivo	11888936
NPM1	SENP3	No	in vitro;in vivo;yeast 2-hybrid	18259216
NPM1	MDM2	No	in vitro;in vivo	15144954
NPM1	TFAP2A	No	in vitro;in vivo	17318229
NPM1	CDK1	No	in vitro;in vivo	12058066 , 11278991
NPM1	HAND2	No	yeast 2-hybrid	11812799
NPM1	ARF1	No	in vitro;in vivo	14636574 , 15684379
NPM1	PLCG2	No	in vivo	9819383
NPM1	NCL	No	in vitro;in vivo;yeast 2-hybrid	10503877 , 8620867
NPM1	GRB2	No	in vitro	8633037
NPM1	EIF2AK2	No	in vitro;in vivo	12882984
NPM1	NOP2	Yes	in vitro	8089149
NPM1	XPO1	No	in vivo	16041368
NPM1	RPGR	No	in vitro;yeast 2-hybrid	15772089
NPM1	GADD45A	No	in vitro;yeast 2-hybrid	15644315
NPM1	TCERG1	No	in vitro	15456888
NPM1	SHC1	No	in vitro	8633037
NPM1	CDK2	No	in vitro;in vivo	11278991 , 16376875
NPM1	TP53	No	in vitro;in vivo	12080348 , 16376884
NPM1	HIST3H3	No	in vitro	11602260
NPM1	PLK1	No	in vitro;in vivo	15190079

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped Reactome pathways