Gene Report

Basic Information

Approved Symbol	LRTOMT
Approved Name	leucine rich transmembrane and 0-methyltransferase domain containing
Previous Symbol	LRRC51, DFNB63
Previous Name	leucine rich repeat containing 51, "deafness, autosomal recessive 63"
Symbol Alias	COMT2
Location	11q13.4
Position	chr11:71791377-71821828 (+)
External Links	Entrez Gene: 220074 Ensembl: ENSG00000184154 UCSC: uc010rqw.2 HGNC ID: 25033
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between LRTOMT and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
Leucine-rich B7 protein	Tochigi, 2008	patients and normal controls		Genes differentially expressed in major depression Genes differentially expressed in major depression

Positive relationships between LRTOMT and other components at different levels (count: 0)

Positive relationship network of LRTOMT in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between LRTOMT and MDD (count: 0)

Negative relationships between LRTOMT and other components at different levels (count: 0)

LRTOMT related SNPs in MK4MDD (count: 0)

LRTOMT related proteins in MK4MDD (count: 2)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Transmembrane O-methyltransferase	Q8WZ04	0(0/0)	Gene mapped
Leucine-rich repeat-containing protein 51	Q96E66	0(0/0)	Gene mapped

LRTOMT related GO terms (count: 8)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0016206	catechol O-methyltransferase activity	molecular function	ISS[18794526]
GO:0060117	auditory receptor cell development	biological process	ISS[18794526]
GO:0007605	sensory perception of sound	biological process	ISS[18794526]
GO:0042424	catecholamine catabolic process	biological process	ISS[18794526]
GO:0016021	integral to membrane	cellular component	IEA
GO:0005575	cellular_component	cellular component	ND
GO:0042135	neurotransmitter catabolic process	biological process	IEA
GO:0005737	cytoplasm	cellular component	IEA

LRTOMT related KEGG pathways (count: 0)

LRTOMT related BioCarta pathways (count: 0)

LRTOMT related Reactome pathways (count: 0)

LRTOMT related interactors from protein-protein interaction data in HPRD (count: 0)

Gene Report

Gene mapped GO terms